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anti-AGRP antibody :: Goat AgRP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS619399 anti-AGRP antibody
Unit / Price
0.1 mg  /  $660 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AgRP, Polyclonal Antibody

 Also Known As   

AgRP (ART, AGRT, ASIP2, Agouti Related Protein Homolog (mouse), Agouti (mouse) Related Protein, Agouti-related Transcript, Mouse, Homolog of)

 Product Synonym Names    Anti -AgRP (ART, AGRT, ASIP2, Agouti Related Protein Homolog (mouse), Agouti (mouse) Related Protein, Agouti-related Transcript, Mouse, Homolog of)
 Product Gene Name   

anti-AGRP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (67516474..67517716, complement). Location: 16q22
 OMIM    601665
 3D Structure    ModBase 3D Structure for O00253
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Canine, Human, Monkey, Mouse
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 Specificity    Recognizes human AGRP. This antibody is expected to recognize both reported isoforms (as represented by NP_001129; NP_015531). Species Crossreactivity: Canine, monkey and mouse.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
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 Immunogen    Synthetic peptide corresponding to human AGRP.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-AGRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-AGRP antibody

   Several common diseases such as type II diabetes, hypertension, cardiovascular diseases, hyperlipidemia, and some cancers are associated with obesity. An abnormal increase in body fat relative to lean tissue mass has been used as an indicator of obesity. High fat diet, certain environmental factors, and genetic linkage are the primary causes of obesity. In order to understand the genetic basis of obesity, several monogenic murine obesity models have been characterized including obese (Ob), diabetes (db), fat (fat), agouti yellow (Ay), and tubby (tub). More recently, Tub, the human homolog of mouse Tub, TULP1 & TULP2 (for Tubby Like Proteins) and Agouti related protein (AGRP) have been cloned. The obesity associated with Ay mice may be due to ectopic expression of a secreted protein Agouti. Agouti protein (132 aa in human) is normally expressed in skin but its ubiquitous expression causes obesity. Agouti is a paracrine-signaling molecule that affects pigmentation by inhibiting the melanocortin receptor 1 (MCR-1). However, recombinant Agouti protein also antagonizes the MC2R and MC4R. AGRP (132 aa in human, chromosome 16q21) is normally expressed in adrenal and hypothalamus. AGRP levels are increased several folds in ob/ob mice. AGRP is a strong antagonist of MC3R and MC4R. Ubiquitous expression of AGRP in transgenic mice causes obesity without altering skin pigmentation.
 Product Categories/Family for anti-AGRP antibody    Antibodies; Abs to Obesity Proteins
 Applications Tested/Suitable for anti-AGRP antibody   

ELISA (EL/EIA)

 Application Notes for anti-AGRP antibody    Suitable for use in ELISA.
Dilution: ELISA: 1:32000
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NCBI/Uniprot data below describe general gene information for AGRP. It may not necessarily be applicable to this product.
 NCBI GI #    4501995
 NCBI GeneID    181
 NCBI Accession #    NP_001129.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001138.1 [Other Products]
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 UniProt Primary Accession #    O00253 [Other Products]
 UniProt Secondary Accession #    O15459; Q2TBD9 [Other Products]
 UniProt Related Accession #    O00253 [Other Products]
 Molecular Weight    14,440 Da [Similar Products]
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 NCBI Official Full Name    agouti-related protein
 NCBI Official Synonym Full Names    agouti related protein homolog (mouse)
 NCBI Official Symbol    AGRP [Similar Products]
 NCBI Official Synonym Symbols   
ART; AGRT; ASIP2; MGC118963
[Similar Products]
 NCBI Protein Information    agouti-related protein; OTTHUMP00000174803
 UniProt Protein Name    Agouti-related protein
 Protein Family    Agouti-related protein
 UniProt Gene Name    AGRP [Similar Products]
 UniProt Synonym Gene Names    AGRT; ART [Similar Products]
 UniProt Entry Name    AGRP_HUMAN
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 NCBI Summary for AGRP    This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq]
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 UniProt Comments for AGRP    AGRP: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. Genetic variations in AGRP may be a cause of obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

Protein type: Secreted; Secreted, signal peptide; Hormone

Chromosomal Location of Human Ortholog: 16q22

Cellular Component: extracellular space; cell soma; Golgi lumen

Molecular Function: neuropeptide hormone activity; receptor binding

Biological Process: maternal process involved in pregnancy; hormone-mediated signaling; neuropeptide signaling pathway; eating behavior; photoperiodism; feeding behavior; adult feeding behavior; response to insulin stimulus

Disease: Obesity
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 Research Articles on AGRP    1. This review defines how peripheral signals (particularly leptin, insulin and glucose) converge on a molecular level in proopiomelanocortin (POMC)- and agouti-related protein (AgRP)-expressing arcuate nucleus neurons to control energy homeostasis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AGRP antibodyPathways associated with anti-AGRP antibody
 Reference Product  PubMed Publications
 MC4R antibody  >99 publications with AGRP and MC4R
 MC3R antibody  >54 publications with AGRP and MC3R
 MC5R antibody  >10 publications with AGRP and MC5R
 GHRL antibody  >1 publications with AGRP and GHRL
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Syndecan-3-mediated Signaling Events Pathway antibodies  Syndecan-3-mediated Signaling Events Pathway Diagram
Diseases associated with anti-AGRP antibodyOrgans/Tissues associated with anti-AGRP antibody
 Disease Name  Pubmed Publications
 Obesity Antibodies  >257 publications with AGRP and Obesity
 Body Weight Changes Antibodies  >108 publications with AGRP and Body Weight Changes
 Diabetes Mellitus Antibodies  >27 publications with AGRP and Diabetes Mellitus
 Inflammation Antibodies  >10 publications with AGRP and Inflammation
 Diabetes Mellitus, Experimental Antibodies  >9 publications with AGRP and Diabetes Mellitus, Experimental
 Diabetes Mellitus, Type 2 Antibodies  >6 publications with AGRP and Diabetes Mellitus, Type 2
 Hypertension Antibodies  >6 publications with AGRP and Hypertension
 Prenatal Exposure Delayed Effects Antibodies  >5 publications with AGRP and Prenatal Exposure Delayed Effects
 Kidney Diseases Antibodies  >5 publications with AGRP and Kidney Diseases
 Pain Antibodies  >4 publications with AGRP and Pain
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >45 publications with AGRP and Connective Tissue
 Kidney Antibodies  >12 publications with AGRP and Kidney
 Lung Antibodies  >1 publications with AGRP and Lung
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