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anti-ACAN antibody :: Rabbit Aggrecan Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS822299
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aggrecan (ACAN), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Aggrecan Antibody

 Product Synonym Names    AGC1; CSPG1; MSK16; Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1
 Product Gene Name   

anti-ACAN antibody

[Similar Products]
 Antibody/Peptide Pairs    Aggrecan peptide (MBS822485) is used for blocking the activity of Aggrecan antibody (MBS822299)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 612813
 3D Structure    ModBase 3D Structure for P16112
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit, Sheep
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 Specificity    Recognizes endogenous levels of Aggrecan protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Aggrecan. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-ACAN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACAN antibody

   Rabbit polyclonal antibody to Aggrecan
 Applications Tested/Suitable for anti-ACAN antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ACAN antibody    WB (1/500 - 1/1000), IH (1/100 - 1/200)
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 Western Blot (WB) of anti-ACAN antibody    Western blot analysis of Aggrecan expression in HeLa colchicine-treated (A), mouse kidney (B), PC12 colchicine-treated (C), NIH3T3 (D) whole cell lysates.
anti-ACAN antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ACAN antibody    Immunohistochemical analysis of Aggrecan staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX
anti-ACAN antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ACAN. It may not necessarily be applicable to this product.
 NCBI GI #    129886
 NCBI GeneID    176
 NCBI Accession #    P16112.2 [Other Products]
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 UniProt Primary Accession #    P16112 [Other Products]
 UniProt Secondary Accession #    Q13650; Q9UCD3; Q9UCP4; Q9UCP5; Q9UDE0 [Other Products]
 UniProt Related Accession #    P16112 [Other Products]
 Molecular Weight    239,235 Da
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 NCBI Official Full Name    Aggrecan core protein
 NCBI Official Synonym Full Names    aggrecan
 NCBI Official Symbol    ACAN [Similar Products]
 NCBI Official Synonym Symbols   
AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP
[Similar Products]
 NCBI Protein Information    aggrecan core protein; large aggregating proteoglycan; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan core protein 1
 UniProt Protein Name    Aggrecan core protein
 UniProt Synonym Protein Names   
Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1
 Protein Family    Aggrecan core protein
 UniProt Gene Name    ACAN [Similar Products]
 UniProt Synonym Gene Names    AGC1; CSPG1; MSK16; CSPCP; Chondroitin sulfate proteoglycan 1 [Similar Products]
 UniProt Entry Name    PGCA_HUMAN
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 NCBI Summary for ACAN    This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACAN    ACAN: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK). Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy. Defects in ACAN are the cause of spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN). A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts. Defects in ACAN are the cause of osteochondritis dissecans short stature and early-onset osteoarthritis (OD). It is a type of osteochondritis defined as a separation of cartilage and subchondral bone from the surrounding tissue, primarily affecting the knee, ankle and elbow joints. It is clinically characterized by multiple osteochondritic lesions in knees and/or hips and/or elbows, disproportionate short stature and early-onset osteoarthritis. Belongs to the aggrecan/versican proteoglycan family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Secreted, signal peptide; Secreted; Cell adhesion

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; lysosomal lumen; Golgi lumen; extracellular region

Molecular Function: protein binding; metal ion binding; extracellular matrix structural constituent; hyaluronic acid binding; carbohydrate binding

Biological Process: keratan sulfate metabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; carbohydrate metabolic process; pathogenesis; keratan sulfate catabolic process; proteolysis; cell adhesion; skeletal development

Disease: Spondyloepiphyseal Dysplasia, Kimberley Type; Osteochondritis Dissecans, Short Stature, And Early-onset Osteoarthritis; Spondyloepimetaphyseal Dysplasia, Aggrecan Type
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 Research Articles on ACAN    1. Heterozygous mutations in ACAN can cause a mild skeletal dysplasia, which presents clinically as short stature with advanced bone age.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACAN antibodyPathways associated with anti-ACAN antibody
 Reference Product  PubMed Publications
 SOX9 antibody  >64 publications with ACAN and SOX9
 ADAMTS5 antibody  >13 publications with ACAN and ADAMTS5
 ADAMTS4 antibody  >9 publications with ACAN and ADAMTS4
 FMOD antibody  >4 publications with ACAN and FMOD
 LUM antibody  >3 publications with ACAN and LUM
 KERA antibody  >1 publications with ACAN and KERA
 Products by Pathway  Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Keratan Sulfate Biosynthesis Pathway antibodies  Keratan Sulfate Biosynthesis Pathway Diagram
 Keratan Sulfate Degradation Pathway antibodies  Keratan Sulfate Degradation Pathway Diagram
 Keratan Sulfate/keratin Metabolism Pathway antibodies  Keratan Sulfate/keratin Metabolism Pathway Diagram
Organs/Tissues associated with anti-ACAN antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >66 publications with ACAN and Bone
 Connective Tissue Antibodies  >28 publications with ACAN and Connective Tissue
 Brain Antibodies  >13 publications with ACAN and Brain
 Embryonic Tissue Antibodies  >8 publications with ACAN and Embryonic Tissue
 Eye Antibodies  >5 publications with ACAN and Eye
 Skin Antibodies  >4 publications with ACAN and Skin
 Adrenal Gland Antibodies  >2 publications with ACAN and Adrenal Gland
 Trachea Antibodies  >2 publications with ACAN and Trachea
 Lung Antibodies  >1 publications with ACAN and Lung
 Kidney Antibodies  >1 publications with ACAN and Kidney
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