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anti-ALDH5A1 antibody :: Rabbit Aldh5A1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151364
Western Blot (WB)
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aldh5A1, Polyclonal Antibody

 Also Known As   

Aldh5A1 Antibody

 Product Synonym Names    Aldh5A1; SSDH; SSADH; Succinate-semialdehyde dehydrogenase; mitochondrial; Aldehyde dehydrogenase family 5 member A1; aldehyde dehydrogenase 5 family, member A1
 Product Gene Name   

anti-ALDH5A1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Aldh5A1 peptide (MBS152067) is used for blocking the activity of Aldh5A1 antibody (MBS151364)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 610045
 3D Structure    ModBase 3D Structure for P51649
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Aldh5A1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    Aldh5A1 antibody was raised against a 22 amino acid synthetic peptide near the carboxy terminus of the human Aldh5A1.
 Buffer    Aldh5A1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    Aldh5A1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-ALDH5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ALDH5A1 antibody

   Aldh5A1 Antibody: Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA). Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.
 Applications Tested/Suitable for anti-ALDH5A1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ALDH5A1 antibody    Aldh5A1 antibody can be used for detection of Aldh5A1 by Western blot at 1 - 2 mug/mL.
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 Western Blot (WB) of anti-ALDH5A1 antibody    Western blot analysis of Aldh5A1 in mouse liver lysate with Aldh5A1 antibody at (A) 1 and (B) 2 μg/mL.
anti-ALDH5A1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ALDH5A1. It may not necessarily be applicable to this product.
 NCBI GI #    25777721
 NCBI GeneID    7915
 NCBI Accession #    NP_733936 [Other Products]
 NCBI GenBank Nucleotide #    NM_170740.1 [Other Products]
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 UniProt Primary Accession #    P51649 [Other Products]
 UniProt Secondary Accession #    Q546H9; Q8N3W6; B2RD26; G5E949 [Other Products]
 UniProt Related Accession #    P51649 [Other Products]
 Molecular Weight    58,653 Da
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 NCBI Official Full Name    succinate-semialdehyde dehydrogenase, mitochondrial isoform 1
 NCBI Official Synonym Full Names    aldehyde dehydrogenase 5 family, member A1
 NCBI Official Symbol    ALDH5A1 [Similar Products]
 NCBI Official Synonym Symbols   
SSDH; SSADH
[Similar Products]
 NCBI Protein Information    succinate-semialdehyde dehydrogenase, mitochondrial; aldehyde dehydrogenase 5 family member A1; mitochondrial succinate semialdehyde dehydrogenase; NAD(+)-dependent succinic semialdehyde dehydrogenase
 UniProt Protein Name    Succinate-semialdehyde dehydrogenase, mitochondrial
 UniProt Synonym Protein Names   
Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenase
 UniProt Gene Name    ALDH5A1 [Similar Products]
 UniProt Synonym Gene Names    SSADH [Similar Products]
 UniProt Entry Name    SSDH_HUMAN
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 NCBI Summary for ALDH5A1    This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ALDH5A1    ALDH5A1: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency). SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development. Belongs to the aldehyde dehydrogenase family.

Protein type: EC 1.2.1.24; Carbohydrate Metabolism - butanoate; Oxidoreductase; Mitochondrial; Amino Acid Metabolism - alanine, aspartate and glutamate

Chromosomal Location of Human Ortholog: 6p22

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: aldehyde dehydrogenase (NAD) activity; protein homodimerization activity; succinate-semialdehyde dehydrogenase activity; succinate-semialdehyde dehydrogenase [NAD(P)+] activity

Biological Process: succinate metabolic process; glutamate metabolic process; neurotransmitter catabolic process; central nervous system development; short-chain fatty acid metabolic process; neurotransmitter secretion; acetate metabolic process; glucose metabolic process; glucosylceramide metabolic process; glutamine metabolic process; post-embryonic development; protein homotetramerization; synaptic transmission; glutathione metabolic process; galactosylceramide metabolic process; glycerophospholipid metabolic process; gamma-aminobutyric acid catabolic process

Disease: Succinic Semialdehyde Dehydrogenase Deficiency
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 Research Articles on ALDH5A1    1. Results show that opioid-dependent patients carrying the T allele of a functional variant in ALDH5A1 had a greater risk of being nonresponders to methadone maintenance treatment
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ALDH5A1 antibodyPathways associated with anti-ALDH5A1 antibody
 Reference Product  PubMed Publications
 ABAT antibody  >1 publications with ALDH5A1 and ABAT
 Products by Pathway  Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Degradation Of GABA Pathway antibodies  Degradation Of GABA Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
Diseases associated with anti-ALDH5A1 antibodyOrgans/Tissues associated with anti-ALDH5A1 antibody
 Disease Name  Pubmed Publications
 succinic semialdehyde dehydrogenase deficiency Antibodies  >51 publications with ALDH5A1 and succinic semialdehyde dehydrogenase deficiency
 Nervous System Diseases Antibodies  >38 publications with ALDH5A1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >9 publications with ALDH5A1 and Disease Models, Animal
 Intellectual Disability Antibodies  >9 publications with ALDH5A1 and Intellectual Disability
 Brain Diseases, Metabolic Antibodies  >6 publications with ALDH5A1 and Brain Diseases, Metabolic
 Poisoning Antibodies  >3 publications with ALDH5A1 and Poisoning
 Liver Diseases Antibodies  >2 publications with ALDH5A1 and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with ALDH5A1 and Kidney Diseases
 Adenocarcinoma Antibodies  >2 publications with ALDH5A1 and Adenocarcinoma
 Neurotoxicity Syndromes Antibodies  >2 publications with ALDH5A1 and Neurotoxicity Syndromes
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >59 publications with ALDH5A1 and Brain
 Liver Antibodies  >13 publications with ALDH5A1 and Liver
 Muscle Antibodies  >8 publications with ALDH5A1 and Muscle
 Kidney Antibodies  >5 publications with ALDH5A1 and Kidney
 Embryonic Tissue Antibodies  >4 publications with ALDH5A1 and Embryonic Tissue
 Eye Antibodies  >3 publications with ALDH5A1 and Eye
 Heart Antibodies  >2 publications with ALDH5A1 and Heart
 Intestine Antibodies  >1 publications with ALDH5A1 and Intestine
 Ovary Antibodies  >1 publications with ALDH5A1 and Ovary
 Pancreas Antibodies  >1 publications with ALDH5A1 and Pancreas
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