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anti-Aif1 antibody :: Rabbit anti-Mouse Allograft inflammatory factor 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1494719
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Allograft inflammatory factor 1 (Aif1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-mouse Allograft inflammatory factor 1 polyclonal Antibody

 Product Synonym Names    onized calcium-binding adapter molecule 1; Iba1
 Product Gene Name   

anti-Aif1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for O70200
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant mouse Allograft inflammatory factor 1 protein(2-147aa)
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-Aif1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Aif1 antibody

   Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
 Applications Tested/Suitable for anti-Aif1 antibody   

ELISA (EIA), Western Blot (WB)

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 Western Blot (WB) of anti-Aif1 antibody    Western blot
All lanes: Allograft inflammatory factor 1 antibody at 2ug/ml+THP-1 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 17kDa
Observed band size: 17kDa

anti-Aif1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Aif1. It may not necessarily be applicable to this product.
 NCBI GI #    9506379
 NCBI GeneID    11629
 NCBI Accession #    NP_062340.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019467.2 [Other Products]
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 UniProt Primary Accession #    O70200 [Other Products]
 UniProt Related Accession #    O70200 [Other Products]
 Molecular Weight    16,911 Da
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 NCBI Official Full Name    allograft inflammatory factor 1
 NCBI Official Synonym Full Names    allograft inflammatory factor 1
 NCBI Official Symbol    Aif1 [Similar Products]
 NCBI Official Synonym Symbols   
G1; Iba1; AIF-1; AI607846; D17H6S50E
[Similar Products]
 NCBI Protein Information    allograft inflammatory factor 1
 UniProt Protein Name    Allograft inflammatory factor 1
 UniProt Synonym Protein Names   
Ionized calcium-binding adapter molecule 1
 Protein Family    Apoptosis-inducing factor
 UniProt Gene Name    Aif1 [Similar Products]
 UniProt Synonym Gene Names    Iba1; AIF-1 [Similar Products]
 UniProt Entry Name    AIF1_MOUSE
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 UniProt Comments for Aif1    AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Cellular Component: actin filament; cell projection; cytoplasm; cytoskeleton; cytosol; lamellipodium; membrane; nucleus; perikaryon; perinuclear region of cytoplasm; phagocytic cup; plasma membrane; ruffle

Molecular Function: actin binding; actin filament binding; calcium ion binding; metal ion binding; protein binding

Biological Process: actin filament bundle formation; actin filament polymerization; microglial cell activation; negative regulation of apoptosis; negative regulation of smooth muscle cell proliferation; phagocytosis, engulfment; positive regulation of cell migration; positive regulation of muscle hyperplasia; positive regulation of nitric oxide biosynthetic process; positive regulation of protein amino acid phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of T cell proliferation; Rac protein signal transduction
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 Research Articles on Aif1    1. These results imply daintain/AIF-1 triggers type 1 diabetes probably via arousing immune cells activation and induction of NO production in pancreas of NOD mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-Aif1 antibodyOrgans/Tissues associated with anti-Aif1 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >336 publications with Aif1 and Disease Models, Animal
 Inflammation Antibodies  >194 publications with Aif1 and Inflammation
 Cardiovascular Diseases Antibodies  >115 publications with Aif1 and Cardiovascular Diseases
 Necrosis Antibodies  >105 publications with Aif1 and Necrosis
 Nerve Degeneration Antibodies  >49 publications with Aif1 and Nerve Degeneration
 Poisoning Antibodies  >20 publications with Aif1 and Poisoning
 Neurotoxicity Syndromes Antibodies  >18 publications with Aif1 and Neurotoxicity Syndromes
 Cognition Disorders Antibodies  >18 publications with Aif1 and Cognition Disorders
 Learning Disorders Antibodies  >17 publications with Aif1 and Learning Disorders
 Parkinson Disease Antibodies  >17 publications with Aif1 and Parkinson Disease
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >504 publications with Aif1 and Brain
 Bone Marrow Antibodies  >44 publications with Aif1 and Bone Marrow
 Eye Antibodies  >37 publications with Aif1 and Eye
 Embryonic Tissue Antibodies  >24 publications with Aif1 and Embryonic Tissue
 Liver Antibodies  >17 publications with Aif1 and Liver
 Spleen Antibodies  >15 publications with Aif1 and Spleen
 Joint Antibodies  >11 publications with Aif1 and Joint
 Lung Antibodies  >10 publications with Aif1 and Lung
 Kidney Antibodies  >10 publications with Aif1 and Kidney
 Pancreas Antibodies  >5 publications with Aif1 and Pancreas
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