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anti-A2M antibody :: Goat anti-Horse Alpha 2-Macroglobulin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS560170 anti-A2M antibody
Unit / Price
0.1 mg  /  $250 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha 2-Macroglobulin (A2M), Polyclonal Antibody

★Popular Item★
 Also Known As   

Affinity Purified Goat anti-Horse Alpha 2 Macroglobulin

 Product Synonym Names    Affinity Purified Goat anti-Horse Alpha 2-Macroglobulin; anti-Horse Alpha 2-Macroglobulin
 Product Gene Name   

anti-A2M antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (9220304..9268558, complement). Location: 12p13.31
 OMIM    103950
 3D Structure    ModBase 3D Structure for P01023
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Horse
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 Purity/Purification    Unconjugated A.P.
 Form/Format    Liquid
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 Buffer    Phosphate buffered saline, pH 7.2
 Preservative    0.1% sodium azide
 Procedure    Goats were immunized with horse macroglobulin. The goats were bled, serum collected then passed over serum protein immunoabsorbant columns lacking alpha 2 macroglobulin. The anti- A2M was immunoaffinity purified off an antigen containing immunoabsorbant.
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 Preparation and Storage    Store at 4 degree C.
Shelf Life: 12 months after shipping date
 Other Notes    Small volumes of anti-A2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-A2M antibody

   Goats were immunized with horse macroglobulins. The resulting antiserum was passed over an antigen containing immunoabsorbant from which the anti-horse macroglobulins were immunoaffinity purified.
 Product Categories/Family for anti-A2M antibody    Horse Protein
 Application Notes for anti-A2M antibody    This product reacts with alpha 2 macroglobulin in serum. It does not react with horse IgM, IgA, IgG or IgG(T) by IEP analysis.
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NCBI/Uniprot data below describe general gene information for A2M. It may not necessarily be applicable to this product.
 NCBI GI #    119608996
 NCBI GeneID    2
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 UniProt Primary Accession #    P01023 [Other Products]
 UniProt Secondary Accession #    Q13677; Q59F47; Q5QTS0; Q68DN2; Q6PIY3; Q6PN97 [Other Products]
 UniProt Related Accession #    P01023; Q9BQ22 [Other Products]
 Molecular Weight    163,291 Da [Similar Products]
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 NCBI Official Full Name    alpha-2-macroglobulin
 NCBI Official Synonym Full Names    alpha-2-macroglobulin
 NCBI Official Symbol    A2M [Similar Products]
 NCBI Official Synonym Symbols   
A2MD; CPAMD5; FWP007; S863-7; DKFZp779B086
[Similar Products]
 NCBI Protein Information    alpha-2-macroglobulin; alpha-2-M; OTTHUMP00000196829; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
 UniProt Protein Name    Alpha-2-macroglobulin
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
 Protein Family    Alpha-2-macroglobulin
 UniProt Gene Name    A2M [Similar Products]
 UniProt Synonym Gene Names    CPAMD5 [Similar Products]
 UniProt Entry Name    A2MG_HUMAN
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 NCBI Summary for A2M    Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq]
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 UniProt Comments for A2M    A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.

Protein type: Inhibitor; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: extracellular region; cytosol

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding

Biological Process: negative regulation of complement activation, lectin pathway; extracellular matrix disassembly; platelet activation; regulation of small GTPase mediated signal transduction; extracellular matrix organization and biogenesis; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway

Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency
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 Research Articles on A2M    1. dimeric alpha2M as well as tetrameric alpha2M may play an important role in controlling beta2-m amyloid fibril formation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-A2M antibodyPathways associated with anti-A2M antibody
 Reference Product  PubMed Publications
 APOE antibody  >61 publications with A2M and APOE
 LRP1 antibody  >10 publications with A2M and LRP1
 MYOC antibody  >1 publications with A2M and MYOC
 IL1B antibody  >1 publications with A2M and IL1B
 B2M antibody  >1 publications with A2M and B2M
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
Diseases associated with anti-A2M antibodyOrgans/Tissues associated with anti-A2M antibody
 Disease Name  Pubmed Publications
 Central Nervous System Diseases Antibodies  >82 publications with A2M and Central Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >80 publications with A2M and Neurodegenerative Diseases
 Alzheimer Disease Antibodies  >75 publications with A2M and Alzheimer Disease
 Neoplasms Antibodies  >29 publications with A2M and Neoplasms
 Inflammation Antibodies  >25 publications with A2M and Inflammation
 Vascular Diseases Antibodies  >15 publications with A2M and Vascular Diseases
 Autoimmune Diseases Antibodies  >14 publications with A2M and Autoimmune Diseases
 Blood Protein Disorders Antibodies  >14 publications with A2M and Blood Protein Disorders
 Necrosis Antibodies  >12 publications with A2M and Necrosis
 Hepatitis Antibodies  >11 publications with A2M and Hepatitis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >109 publications with A2M and Blood
 Liver Antibodies  >30 publications with A2M and Liver
 Brain Antibodies  >27 publications with A2M and Brain
 Vascular Antibodies  >13 publications with A2M and Vascular
 Lung Antibodies  >10 publications with A2M and Lung
 Prostate Antibodies  >8 publications with A2M and Prostate
 Heart Antibodies  >7 publications with A2M and Heart
 Uterus Antibodies  >6 publications with A2M and Uterus
 Placenta Antibodies  >5 publications with A2M and Placenta
 Embryonic Tissue Antibodies  >5 publications with A2M and Embryonic Tissue
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