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anti-A2m antibody :: Goat anti-Rat Alpha 2-Macroglobulin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS560662 anti-A2m antibody
Unit / Price
0.1 mg  /  $250 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha 2-Macroglobulin (A2m), Polyclonal Antibody

★Popular Item★
 Also Known As   

Affinity Purified Goat anti-Rat Alpha 2-Macroglobulin

 Product Synonym Names    Affinity PurifiedGoat anti-Rat Alpha 2-Macroglobulin; anti-Rat Alpha 2-Macroglobulin
 Product Gene Name   

anti-A2m antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000072.5 (128433585..128476738, complement). Location: 6 F1-G3; 6 62.0 cM
 3D Structure    ModBase 3D Structure for Q61838
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Rat
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 Purity/Purification    Unconjugated A.P.
 Form/Format    Liquid
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 Preservative    0.1% sodium azide
 Procedure    Goats were immunized with rat Alpha 2-Macroglobulin isolated from acute phase rat serum. The resulting antiserum was solid phase absorbed with rat serum lacking alpha 2- macroglobulin until it gave a single band with serum containing the acute phase protein. The specific antibodies were then immunoaffinity purified off an antigen containing immunoabsorbant.
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 Preparation and Storage    Store at 4 degree C.
Shelf Life: 12 months from shipment date
 Other Notes    Small volumes of anti-A2m antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-A2m antibody

   Goats were immunized with rat Alpha 2-Macroglobulin (A2M). The resulting antiserum was passed over an antigen containing immunoabsorbant from which the anti-rat A2M was immunoaffinity purified.
 Product Categories/Family for anti-A2m antibody    Rat Protein
 Application Notes for anti-A2m antibody    The Goat anti-Rat A2M gives a single band against acute phase rat serum by IEP and gel diffusion analysis. This product is suitable for ELISA and blotting applications.
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NCBI/Uniprot data below describe general gene information for A2m. It may not necessarily be applicable to this product.
 NCBI GI #    110347469
 NCBI GeneID    11287
 NCBI Accession #    NP_031402.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_007376.4 [Other Products]
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 UniProt Primary Accession #    Q61838 [Other Products]
 UniProt Secondary Accession #    Q60628; Q6PEM2; E9QPW0 [Other Products]
 UniProt Related Accession #    Q61838 [Other Products]
 Molecular Weight    165,853 Da [Similar Products]
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 NCBI Official Full Name    alpha-2-macroglobulin
 NCBI Official Synonym Full Names    pregnancy zone protein
 NCBI Official Synonym Symbols   
A1m; A2m; MAM; AI893533
[Similar Products]
 NCBI Protein Information    alpha-2-macroglobulin; alpha-2-M; OTTMUSP00000025075; alpha 1 macroglobulin
 UniProt Protein Name    Alpha-2-macroglobulin
 UniProt Synonym Protein Names   
Pregnancy zone protein
 Protein Family    Alpha-2-macroglobulin
 UniProt Gene Name    A2m [Similar Products]
 UniProt Synonym Gene Names    Pzp [Similar Products]
 UniProt Entry Name    A2M_MOUSE
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 UniProt Comments for A2m    PZP: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protease inhibitor activity; endopeptidase inhibitor activity; protein complex binding

Biological Process: negative regulation of peptidase activity; embryo implantation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-A2m antibodyOrgans/Tissues associated with anti-A2m antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13 publications with A2m and Neoplasms
 Breast Neoplasms Antibodies  >6 publications with A2m and Breast Neoplasms
 Carcinoma Antibodies  >6 publications with A2m and Carcinoma
 Drug Toxicity Antibodies  >4 publications with A2m and Drug Toxicity
 Ovarian Neoplasms Antibodies  >3 publications with A2m and Ovarian Neoplasms
 Uterine Neoplasms Antibodies  >3 publications with A2m and Uterine Neoplasms
 Adenocarcinoma Antibodies  >2 publications with A2m and Adenocarcinoma
 Brain Diseases Antibodies  >2 publications with A2m and Brain Diseases
 Endometrial Neoplasms Antibodies  >2 publications with A2m and Endometrial Neoplasms
 Hypertension Antibodies  >2 publications with A2m and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with A2m and Brain
 Embryonic Tissue Antibodies  >10 publications with A2m and Embryonic Tissue
 Liver Antibodies  >9 publications with A2m and Liver
 Muscle Antibodies  >4 publications with A2m and Muscle
 Kidney Antibodies  >2 publications with A2m and Kidney
 Lung Antibodies  >1 publications with A2m and Lung
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