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anti-CRYAB antibody :: Rabbit Alpha B Crystallin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS194398 anti-CRYAB antibody
Unit / Price
0.1 mL  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha B Crystallin (CRYAB), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Alpha B Crystallin Polyclonal Antibody

 Product Synonym Names    Alpha B Crystallin; Anti-Alpha B Crystallin Polyclonal Antibody
 Product Gene Name   

anti-CRYAB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (111779350..111782473, complement). Location: 11q22.3-q23.1
 OMIM    123590
 3D Structure    ModBase 3D Structure for P02511
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 Clonality    Polyclonal
 Host    Rabbit
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 Specificity    Alpha B Crystallin [Rabbit antibody recognizes Alpha B Crystallin of multiple species]
This antibody recognizes human, mouse, rat, bovine, and chicken alpha B crystallin. It does not cross-react with alpha A crystallin.
 Form/Format    100ul whole antiserum
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 Antigen    Synthetic peptide corresponding to human alpha B crystallin.
 Preservatives    None.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-CRYAB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CRYAB antibody

   Alpha crystallins are water-soluble lens proteins of the vertebrate eye that are related to the small heat shock protein family. Lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are further divided into acidic (Alpha A) and basic (Alpha B) groups. In the lens, alpha crystallin maintains proper refractive index, however it can also function as a molecular chaperone that binds to denatured proteins, keeping them in solution and maintaining the translucency of the lens. In response to cellular stress, alpha crystallin is phosphorlyated and may serve a structural control function and play a role in protein maintenance. Both alpha A and alpha B crystallin prevent apoptosis by inhibiting caspases. Alpha B crystallin is found in many cells and organs outside the lens and is over-expressed in cells subjected to stress conditions and in several neurological disorders.
 Product Categories/Family for anti-CRYAB antibody    Heat Shock and Stress Proteins
 Applications Tested/Suitable for anti-CRYAB antibody   

Immunoblot

 Application Notes for anti-CRYAB antibody    Immunoblotting: use at 1:5,000-1:10,000 dilution. A band of ~22 kDa is detected.
These are recommended concentrations.
User should determine optimal concentrations for their application.
Positive control: HeLa cell lysate.
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NCBI/Uniprot data below describe general gene information for CRYAB. It may not necessarily be applicable to this product.
 NCBI GI #    227018373
 NCBI GeneID    1410
 NCBI Accession #    ACP18852.1 [Other Products]
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 UniProt Primary Accession #    P02511 [Other Products]
 UniProt Secondary Accession #    O43416; Q9UC37; Q9UC38; Q9UC39; Q9UC40; Q9UC41; B0YIX0 [Other Products]
 UniProt Related Accession #    P02511 [Other Products]
 Molecular Weight    20,159 Da [Similar Products]
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 NCBI Official Full Name    alpha B crystallin
 NCBI Official Synonym Full Names    crystallin, alpha B
 NCBI Official Symbol    CRYAB [Similar Products]
 NCBI Official Synonym Symbols   
CRYA2; CTPP2; HSPB5
[Similar Products]
 NCBI Protein Information    alpha-crystallin B chain; OTTHUMP00000234278; OTTHUMP00000234282; OTTHUMP00000234283; OTTHUMP00000234284; OTTHUMP00000234287; OTTHUMP00000234289; alpha B crystallin; alpha(B)-crystallin; alpha crystallin B chain; heat shock protein beta-5; rosenthal fiber component; heat-shock 20 kD like-protein; renal carcinoma antigen NY-REN-27
 UniProt Protein Name    Alpha-crystallin B chain
 UniProt Synonym Protein Names   
Alpha(B)-crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component
 Protein Family    Alpha-crystallin
 UniProt Gene Name    CRYAB [Similar Products]
 UniProt Synonym Gene Names    CRYA2 [Similar Products]
 UniProt Entry Name    CRYAB_HUMAN
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 NCBI Summary for CRYAB    Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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 UniProt Comments for CRYAB    CRYAB: a major structural protein of the eye lens. A member of the small heat shock protein (sHSP also known as the HSP20) family. Alpha-B is expressed in the lens as well as other tissues. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 11q22.3-q23.1

Cellular Component: microtubule cytoskeleton; Golgi apparatus; cell surface; mitochondrion; cytoplasm; plasma membrane; actin filament bundle; nucleus; cytosol; Z disc

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; microtubule binding; metal ion binding; unfolded protein binding; structural constituent of eye lens

Biological Process: lens development in camera-type eye; muscle development; protein folding; microtubule polymerization or depolymerization; stress-activated MAPK cascade; negative regulation of caspase activity; response to estradiol stimulus; tubulin folding; response to hydrogen peroxide; muscle contraction; negative regulation of intracellular transport; response to hypoxia; negative regulation of cell growth; protein homooligomerization; aging; negative regulation of apoptosis

Disease: Cataract 16, Multiple Types; Myopathy, Myofibrillar, Fatal Infantile Hypertonic, Alpha-b Crystallin-related; Myopathy, Myofibrillar, 2; Cardiomyopathy, Dilated, 1ii
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 Research Articles on CRYAB    1. These findings indicate a novel function for BAG3 in inhibiting protein aggregation caused by the genetic mutation of CRYAB responsible for human myofibrillar myopathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRYAB antibodyPathways associated with anti-CRYAB antibody
 Reference Product  PubMed Publications
 CRYAA antibody  >11 publications with CRYAB and CRYAA
 HSPB1 antibody  >9 publications with CRYAB and HSPB1
 CRYGC antibody  >9 publications with CRYAB and CRYGC
 CRYBB2 antibody  >8 publications with CRYAB and CRYBB2
 Products by Pathway  Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with anti-CRYAB antibodyOrgans/Tissues associated with anti-CRYAB antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >31 publications with CRYAB and Cardiovascular Diseases
 Heart Diseases Antibodies  >30 publications with CRYAB and Heart Diseases
 Cardiomyopathies Antibodies  >25 publications with CRYAB and Cardiomyopathies
 Cataract Antibodies  >22 publications with CRYAB and Cataract
 Neoplasms Antibodies  >19 publications with CRYAB and Neoplasms
 Heart Failure Antibodies  >18 publications with CRYAB and Heart Failure
 Central Nervous System Diseases Antibodies  >14 publications with CRYAB and Central Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >12 publications with CRYAB and Neurodegenerative Diseases
 Demyelinating Diseases Antibodies  >12 publications with CRYAB and Demyelinating Diseases
 Carcinoma Antibodies  >10 publications with CRYAB and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >47 publications with CRYAB and Muscle
 Heart Antibodies  >41 publications with CRYAB and Heart
 Nerve Antibodies  >30 publications with CRYAB and Nerve
 Eye Antibodies  >16 publications with CRYAB and Eye
 Brain Antibodies  >15 publications with CRYAB and Brain
 Embryonic Tissue Antibodies  >5 publications with CRYAB and Embryonic Tissue
 Bone Antibodies  >4 publications with CRYAB and Bone
 Spinal Cord Antibodies  >3 publications with CRYAB and Spinal Cord
 Kidney Antibodies  >2 publications with CRYAB and Kidney
 Lung Antibodies  >2 publications with CRYAB and Lung
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