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anti-CRYAB antibody :: Rabbit Alpha B Crystallin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS766557 anti-CRYAB antibody
Unit / Price
0.1 mg  /  $265 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha B Crystallin (CRYAB), Polyclonal Antibody

 Also Known As   

Alpha B Crystallin Rabbit Polyclonal

 Product Gene Name   

anti-CRYAB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123590
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    >=95% as determined by SDS-PAGE
Immunogen Affinity Purified
 Form/Format    Liquid
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 Immunogen    Crystallin, alpha B
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 Preparation and Storage    PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CRYAB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CRYAB antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for CRYAB. It may not necessarily be applicable to this product.
 NCBI GI #    537532
 NCBI GeneID    1410
 NCBI Accession #    AAA60267.1 [Other Products]
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 UniProt Secondary Accession #    O43416; Q9UC37; Q9UC38; Q9UC39; Q9UC40; Q9UC41; B0YIX0 [Other Products]
 UniProt Related Accession #    P02511 [Other Products]
 Molecular Weight    20,159 Da [Similar Products]
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 NCBI Official Full Name    alpha-B-crystallin, partial
 NCBI Official Synonym Full Names    crystallin alpha B
 NCBI Official Symbol    CRYAB [Similar Products]
 NCBI Official Synonym Symbols   
MFM2; CRYA2; CTPP2; HSPB5; CMD1II; CTRCT16; HEL-S-101
[Similar Products]
 NCBI Protein Information    alpha-crystallin B chain
 UniProt Protein Name    Alpha-crystallin B chain
 UniProt Synonym Protein Names   
Alpha(B)-crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component
 Protein Family    Alpha-crystallin
 UniProt Gene Name    CRYAB [Similar Products]
 UniProt Synonym Gene Names    CRYA2; HSPB5; HspB5 [Similar Products]
 UniProt Entry Name    CRYAB_HUMAN
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 NCBI Summary for CRYAB    Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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 UniProt Comments for CRYAB    CRYAB: a major structural protein of the eye lens. A member of the small heat shock protein (sHSP also known as the HSP20) family. Alpha-B is expressed in the lens as well as other tissues. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.

Protein type: Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 11q22.3-q23.1

Cellular Component: actin filament bundle; cell surface; cytoplasm; cytosol; Golgi apparatus; microtubule cytoskeleton; mitochondrion; myelin sheath; nucleoplasm; nucleus; plasma membrane; Z disc

Molecular Function: identical protein binding; metal ion binding; microtubule binding; protein binding; protein homodimerization activity; structural constituent of eye lens; unfolded protein binding

Biological Process: aging; lens development in camera-type eye; microtubule polymerization or depolymerization; muscle contraction; muscle development; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of cell growth; negative regulation of intracellular transport; protein folding; protein homooligomerization; response to estradiol stimulus; response to hydrogen peroxide; response to hypoxia; stress-activated MAPK cascade; tubulin folding

Disease: Cardiomyopathy, Dilated, 1ii; Cataract 16, Multiple Types; Myopathy, Myofibrillar, 2; Myopathy, Myofibrillar, Fatal Infantile Hypertonic, Alpha-b Crystallin-related
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 Research Articles on CRYAB    1. Since alpha-crystallins play an important role in preventing cataract in the eye lens and in the development of diverse diseases, understanding their mechanism and substrate spectra is of importance. [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRYAB antibodyPathways associated with anti-CRYAB antibody
 Reference Product  PubMed Publications
 CRYBB2 antibody  >15 publications with CRYAB and CRYBB2
 CRYGC antibody  >14 publications with CRYAB and CRYGC
 CRYBB3 antibody  >9 publications with CRYAB and CRYBB3
 HSF4 antibody  >9 publications with CRYAB and HSF4
 DRD2 antibody  >3 publications with CRYAB and DRD2
 TP53 antibody  >2 publications with CRYAB and TP53
 VEGFA antibody  >2 publications with CRYAB and VEGFA
 MAPK14 antibody  >1 publications with CRYAB and MAPK14
 Products by Pathway  Pathway Diagram
 Longevity Regulating Pathway - Multiple Species antibodies  Longevity Regulating Pathway - Multiple Species Diagram
 Longevity Regulating Pathway - Multiple Species antibodies  Longevity Regulating Pathway - Multiple Species Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with anti-CRYAB antibodyOrgans/Tissues associated with anti-CRYAB antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >72 publications with CRYAB and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >61 publications with CRYAB and Cardiovascular Diseases
 Heart Diseases Antibodies  >59 publications with CRYAB and Heart Diseases
 Cataract Antibodies  >46 publications with CRYAB and Cataract
 Brain Diseases Antibodies  >27 publications with CRYAB and Brain Diseases
 Neurodegenerative Diseases Antibodies  >23 publications with CRYAB and Neurodegenerative Diseases
 Inflammation Antibodies  >16 publications with CRYAB and Inflammation
 Breast Neoplasms Antibodies  >16 publications with CRYAB and Breast Neoplasms
 Necrosis Antibodies  >12 publications with CRYAB and Necrosis
 Neurobehavioral Manifestations Antibodies  >5 publications with CRYAB and Neurobehavioral Manifestations
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >94 publications with CRYAB and Muscle
 Heart Antibodies  >79 publications with CRYAB and Heart
 Brain Antibodies  >45 publications with CRYAB and Brain
 Eye Antibodies  >40 publications with CRYAB and Eye
 Nerve Antibodies  >37 publications with CRYAB and Nerve
 Vascular Antibodies  >13 publications with CRYAB and Vascular
 Bone Antibodies  >9 publications with CRYAB and Bone
 Lung Antibodies  >8 publications with CRYAB and Lung
 Spinal Cord Antibodies  >8 publications with CRYAB and Spinal Cord
 Embryonic Tissue Antibodies  >6 publications with CRYAB and Embryonic Tissue
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