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anti-AFP antibody :: Rabbit anti-Human Alpha-Fetoprotein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS373005
Unit / Price
5 Control Slides  /  $130 +1 FREE 8GB USB
3 ml (Prediluted)  /  $150 +1 FREE 8GB USB
0.1 mL (Concentrate)  /  $160 +1 FREE 8GB USB
0.5 mL (Concentrate)  /  $180 +1 FREE 8GB USB
7 ml (Prediluted)  /  $195 +1 FREE 8GB USB
1 mL (Concentrate)  /  $215 +1 FREE 8GB USB
15 ml (Prediluted)  /  $280 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha-Fetoprotein (AFP), Polyclonal Antibody

 Also Known As   

Alpha-Fetoprotein

 Product Gene Name   

anti-AFP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104150
 3D Structure    ModBase 3D Structure for P02771
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 Clonality    Polyclonal
 Isotype    IgG
 Clone Number    polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Alpha-Fetoprotein is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
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 Control    Fetal Liver
 Localization    Cytoplasmic
 Reactivity Note    Paraffin, Frozen
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 Preparation and Storage    Store at 2 to 8 degree C in the dark.
 Other Notes    Small volumes of anti-AFP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AFP antibody

   Alpha-fetoprotein (AFP) is a protein which in humans is encoded by the AFP gene. This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. This protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem on chromosome 4. Positive staining with this antibody is seen in hepatocytes of fetal liver and hepatoma. Since only traces of AFP are found in adult serum, elevated levels suggest either a benign or malignant lesion of the liver, a Yolk-Sac Carcinoma, or one of a few other tumors. In conjunction with elevated serum levels, AFP has been immunohistochemically demonstrated in Yolk-Sac Carcinomas in gonadal and extragonadal sites of hepatic malignancies and a few other neoplasms.
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 Dilution Information of anti-AFP antibody    anti-AFP antibody Dilution Information image
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 Immunohistochemistry (IHC) of anti-AFP antibody    anti-AFP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for AFP. It may not necessarily be applicable to this product.
 NCBI GI #    178236
 NCBI Accession #    AAB58754.1 [Other Products]
 NCBI GenBank Nucleotide #    M16110.1 [Other Products]
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 UniProt Primary Accession #    P02771 [Other Products]
 UniProt Secondary Accession #    B2RBU3 [Other Products]
 Molecular Weight    68,678 Da [Similar Products]
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 NCBI Official Full Name    alpha-fetoprotein
 UniProt Protein Name    Alpha-fetoprotein
 UniProt Synonym Protein Names   
Alpha-1-fetoprotein; Alpha-fetoglobulin
 Protein Family    Alpha-fetoprotein
 UniProt Gene Name    AFP [Similar Products]
 UniProt Synonym Gene Names    HPAFP [Similar Products]
 UniProt Entry Name    FETA_HUMAN
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 NCBI Summary for AFP    This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AFP    Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.

Subunit structure: Dimeric and trimeric forms have been found in addition to the monomeric form.

Subcellular location: Secreted.

Tissue specificity: Plasma. Synthesized by the fetal liver and yolk sac.

Developmental stage: Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.

Post-translational modification: Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.Sulfated.

Sequence similarities: Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AFP antibodyPathways associated with anti-AFP antibody
 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with AFP and FLNA
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
Diseases associated with anti-AFP antibodyOrgans/Tissues associated with anti-AFP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4487 publications with AFP and Neoplasms
 Carcinoma Antibodies  >3321 publications with AFP and Carcinoma
 Liver Diseases Antibodies  >3093 publications with AFP and Liver Diseases
 Liver Neoplasms Antibodies  >3033 publications with AFP and Liver Neoplasms
 Adenocarcinoma Antibodies  >2675 publications with AFP and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >2652 publications with AFP and Carcinoma, Hepatocellular
 Hepatitis Antibodies  >872 publications with AFP and Hepatitis
 Liver Cirrhosis Antibodies  >837 publications with AFP and Liver Cirrhosis
 Congenital Abnormalities Antibodies  >730 publications with AFP and Congenital Abnormalities
 Male Urogenital Diseases Antibodies  >638 publications with AFP and Male Urogenital Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3740 publications with AFP and Liver
 Blood Antibodies  >3032 publications with AFP and Blood
 Vascular Antibodies  >395 publications with AFP and Vascular
 Lung Antibodies  >334 publications with AFP and Lung
 Brain Antibodies  >294 publications with AFP and Brain
 Embryonic Tissue Antibodies  >260 publications with AFP and Embryonic Tissue
 Muscle Antibodies  >163 publications with AFP and Muscle
 Kidney Antibodies  >161 publications with AFP and Kidney
 Placenta Antibodies  >153 publications with AFP and Placenta
 Heart Antibodies  >92 publications with AFP and Heart
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