AAA52468.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
284,539 Da
NCBI Official Full Name
alpha-fodrin, partial
NCBI Official Synonym Full Names
spectrin, alpha, non-erythrocytic 1
NCBI Protein Information
spectrin alpha chain, non-erythrocytic 1; alpha-fodrin; alpha-II spectrin; fodrin alpha chain; spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit
UniProt Protein Name
Spectrin alpha chain, non-erythrocytic 1
UniProt Synonym Protein Names
Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit
UniProt Synonym Gene Names
UniProt Entry Name
SPTN1_HUMAN
NCBI Summary for SPTAN1
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
UniProt Comments for SPTAN1
SPTAN1: a cytoskeletal protein which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Capable to forming dimers which can further associate to tetramers.
Protein type: Cytoskeletal; Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: spectrin; microtubule cytoskeleton; membrane; intracellular membrane-bound organelle; fascia adherens; cytosol; Z disc; vesicle; lateral plasma membrane
Molecular Function: calmodulin binding; protein binding; spectrin binding; structural constituent of cytoskeleton; protein heterodimerization activity; calcium ion binding; actin binding
Biological Process: axon guidance; apoptosis; actin filament capping; cell structure disassembly during apoptosis
Disease: Epileptic Encephalopathy, Early Infantile, 5
Research Articles on SPTAN1
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Pathways associated with anti-SPTAN1 antibody
Diseases associated with anti-SPTAN1 antibody
Organs/Tissues associated with anti-SPTAN1 antibody
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