Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow ENSA rightarrow Polyclonal ENSA  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • NADH-cytochrome b5 reductase 3 (CYB5R3) Antibody
 • roundabout homolog 4, magic roundabout (Drosophila) (ROBO4) ELISA Kit
 • Bone Morphogenetic Protein Receptor II (BMPR2) ELISA Kit
 • Galanthus Navalis Agglutinin (GNA) ELISA Kit
 • Transferrin Receptor, soluble (TFRC) Protein
 • L-threonine 3-dehydrogenase, mitochondrial (TDH) ELISA Kit
 • 1,4-dihydroxy-2-naphthoyl-C oA hydrolase (P9303_27301) Recombinant Protein
 • LATS2 Recombinant Protein
 • Cathepsin D (CTSD) Antibody
 • ADH1 ELISA Kit
 • MLANA Antibody
 • C-Peptide ELISA Kit
 • Major allergen Equ c 1 (LOC100034197) Recombinant Protein
 • Cotinine-4 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-ENSA antibody :: Rabbit anti-Human Alpha-endosulfine Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7004318
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha-endosulfine (ENSA), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Alpha-endosulfine polyclonal Antibody

 Product Synonym Names    Alpha-endosulfine protein; ARPP-19e
 Product Gene Name   

anti-ENSA antibody

[Similar Products]
 Product Synonym Gene Name    ENSA [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    603061
 3D Structure    ModBase 3D Structure for O43768
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
Section Bar
 Immunogen    Recombinant human Alpha-endosulfine protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-161563
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ENSA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-ENSA antibody

   Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.

This protein belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
 Product Categories/Family for anti-ENSA antibody    Cell Cycle
 Applications Tested/Suitable for anti-ENSA antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-ENSA antibody    Recommended dilution: IHC: 1:20-1:200
Section Bar
 Immunohistochemistry (IHC) of anti-ENSA antibody    Immunohistochemistry of paraffin-embeded human kidney using MBS7004318 at dilution of 1:50
anti-ENSA antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunofluorescence (IF) of anti-ENSA antibody    Immunofluorescent analysis of Hela cells using MBS7004318 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-ENSA antibody Immunofluorescence (IF) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for ENSA. It may not necessarily be applicable to this product.
 NCBI GI #    4758272
 NCBI GeneID    2029
 NCBI Accession #    NP_004427.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004436.2 [Other Products]
Section Bar
 UniProt Primary Accession #    O43768 [Other Products]
 UniProt Secondary Accession #    Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; A8K1Z9; E9PB69 [Other Products]
 UniProt Related Accession #    O43768 [Other Products]
 Molecular Weight    14,868 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    alpha-endosulfine isoform 3
 NCBI Official Synonym Full Names    endosulfine alpha
 NCBI Official Symbol    ENSA [Similar Products]
 NCBI Official Synonym Symbols   
ARPP-19e
[Similar Products]
 NCBI Protein Information    alpha-endosulfine
 UniProt Protein Name    Alpha-endosulfine
 UniProt Synonym Protein Names   
ARPP-19e
 Protein Family    Alpha-endosulfine
 UniProt Gene Name    ENSA [Similar Products]
 UniProt Entry Name    ENSA_HUMAN
Section Bar
 NCBI Summary for ENSA    The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for ENSA    Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Table BarTOPTable Bar
 Research Articles on ENSA    1. Taken together our results suggest a hierarchy of phosphatases coordinating Greatwall, Ensa/ARPP19 and Cdk substrate dephosphorylation during mitotic exit.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-ENSA antibodyDiseases associated with anti-ENSA antibody
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 MASTL Facilitates Mitotic Progression Pathway antibodies  MASTL Facilitates Mitotic Progression Pathway Diagram
 Mitotic Prophase Pathway antibodies  Mitotic Prophase Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >5 publications with ENSA and Liver Diseases
 Liver Neoplasms Antibodies  >4 publications with ENSA and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with ENSA and Carcinoma, Hepatocellular
 Kidney Neoplasms Antibodies  >2 publications with ENSA and Kidney Neoplasms
 Breast Neoplasms Antibodies  >2 publications with ENSA and Breast Neoplasms
 Disease Models, Animal Antibodies  >2 publications with ENSA and Disease Models, Animal
 Carcinoma Antibodies  >2 publications with ENSA and Carcinoma
 Kidney Diseases Antibodies  >2 publications with ENSA and Kidney Diseases
 Neoplasms, Experimental Antibodies  >1 publications with ENSA and Neoplasms, Experimental
 Liver Neoplasms, Experimental Antibodies  >1 publications with ENSA and Liver Neoplasms, Experimental
Organs/Tissues associated with anti-ENSA antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with ENSA and Blood
 Liver Antibodies  >10 publications with ENSA and Liver
 Adipose Tissue Antibodies  >7 publications with ENSA and Adipose Tissue
 Muscle Antibodies  >7 publications with ENSA and Muscle
 Kidney Antibodies  >7 publications with ENSA and Kidney
 Heart Antibodies  >5 publications with ENSA and Heart
 Connective Tissue Antibodies  >5 publications with ENSA and Connective Tissue
 Thyroid Antibodies  >4 publications with ENSA and Thyroid
 Vascular Antibodies  >3 publications with ENSA and Vascular
 Brain Antibodies  >3 publications with ENSA and Brain
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions