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anti-ACTA2 antibody :: Rabbit Alpha smooth muscle Actin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9200862
Western Blot (WB)
Unit / Price
0.1 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha smooth muscle Actin (ACTA2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Alpha smooth muscle Actin Antibody

 Product Synonym Names    Actin; aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein; ACTA2; ACTSA; ACTVS
 Product Gene Name   

anti-ACTA2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    301-375
 OMIM    102620
 3D Structure    ModBase 3D Structure for P62736
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Chicken, Cat, Dog, Guinea Pig, Hamster, Rabbit, Sheep
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 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
 Concentration    1mg/ml (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    KLH conjugated synthetic peptide derived from human Actin alpha C-terminus
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 Preparation and Storage    Shipped at 4 degree, Store at -20 degree  (Avoid repeated freeze/thaw cycles).
 Other Notes    Small volumes of anti-ACTA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACTA2 antibody

   Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
 Product Categories/Family for anti-ACTA2 antibody    Cardiovascular; Developmental Biology; Signal Transduction
 Applications Tested/Suitable for anti-ACTA2 antibody   

Western Blot (WB)

 Application Notes for anti-ACTA2 antibody    WB~~ 1:500
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 Western Blot (WB) of anti-ACTA2 antibody    Western blot analysis of lysate from human skeletal muscle tissue lysate,using alpha smooth muscle Actin Antibody(MBS9200862). MBS9200862 was diluted at 1:500. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
anti-ACTA2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ACTA2. It may not necessarily be applicable to this product.
 NCBI GI #    213688375
 NCBI GeneID    59
 NCBI Accession #    NP_001135417.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001141945.1 [Other Products]
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 UniProt Primary Accession #    P62736 [Other Products]
 UniProt Secondary Accession #    P03996; P04108; Q6FI19; B2R8A4 [Other Products]
 UniProt Related Accession #    P62736 [Other Products]
 Molecular Weight    42009
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 NCBI Official Full Name    actin, aortic smooth muscle
 NCBI Official Synonym Full Names    actin, alpha 2, smooth muscle, aorta
 NCBI Official Symbol    ACTA2 [Similar Products]
 NCBI Official Synonym Symbols   
AAT6; ACTSA; MYMY5
[Similar Products]
 NCBI Protein Information    actin, aortic smooth muscle
 UniProt Protein Name    Actin, aortic smooth muscle
 UniProt Synonym Protein Names   
Alpha-actin-2; Cell growth-inhibiting gene 46 protein
 Protein Family    Actin
 UniProt Gene Name    ACTA2 [Similar Products]
 UniProt Synonym Gene Names    ACTSA; ACTVS [Similar Products]
 UniProt Entry Name    ACTA_HUMAN
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 NCBI Summary for ACTA2    The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
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 UniProt Comments for ACTA2    ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Contractile

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton

Molecular Function: protein kinase binding; ATP binding

Biological Process: muscle contraction; response to virus; regulation of blood pressure; vascular smooth muscle contraction

Disease: Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome; Aortic Aneurysm, Familial Thoracic 6
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Product References and Citations for anti-ACTA2 antibody

   Kamada S.,et al.Nucleic Acids Res. 17:1767-1767(1989).
Reddy S.,et al.J. Biol. Chem. 265:1683-1687(1990).
Kim J.W.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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 Research Articles on ACTA2    1. We report a case of ACTA2 mutation in a 3-year-old girl presenting with acute ischemic stroke
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACTA2 antibodyPathways associated with anti-ACTA2 antibody
 Reference Product  PubMed Publications
 MYH11 antibody  >31 publications with ACTA2 and MYH11
 SRF antibody  >13 publications with ACTA2 and SRF
 MYOCD antibody  >6 publications with ACTA2 and MYOCD
 TPM3 antibody  >4 publications with ACTA2 and TPM3
 TPM2 antibody  >1 publications with ACTA2 and TPM2
 TPM1 antibody  >1 publications with ACTA2 and TPM1
 UBC antibody  >1 publications with ACTA2 and UBC
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Diseases associated with anti-ACTA2 antibodyOrgans/Tissues associated with anti-ACTA2 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >277 publications with ACTA2 and Fibrosis
 Cardiovascular Diseases Antibodies  >122 publications with ACTA2 and Cardiovascular Diseases
 Inflammation Antibodies  >87 publications with ACTA2 and Inflammation
 Liver Diseases Antibodies  >82 publications with ACTA2 and Liver Diseases
 Disease Models, Animal Antibodies  >75 publications with ACTA2 and Disease Models, Animal
 Liver Cirrhosis Antibodies  >60 publications with ACTA2 and Liver Cirrhosis
 Kidney Diseases Antibodies  >48 publications with ACTA2 and Kidney Diseases
 Heart Diseases Antibodies  >39 publications with ACTA2 and Heart Diseases
 Aortic Aneurysm, Thoracic Antibodies  >36 publications with ACTA2 and Aortic Aneurysm, Thoracic
 Breast Neoplasms Antibodies  >35 publications with ACTA2 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >691 publications with ACTA2 and Muscle
 Vascular Antibodies  >219 publications with ACTA2 and Vascular
 Blood Antibodies  >161 publications with ACTA2 and Blood
 Lung Antibodies  >122 publications with ACTA2 and Lung
 Eye Antibodies  >117 publications with ACTA2 and Eye
 Connective Tissue Antibodies  >106 publications with ACTA2 and Connective Tissue
 Liver Antibodies  >105 publications with ACTA2 and Liver
 Kidney Antibodies  >86 publications with ACTA2 and Kidney
 Skin Antibodies  >74 publications with ACTA2 and Skin
 Heart Antibodies  >59 publications with ACTA2 and Heart
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