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anti-SNCA antibody :: Rabbit anti-Human Alpha-synuclein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7002897
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha-synuclein (SNCA), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Alpha-synuclein polyclonal Antibody

 Product Synonym Names    Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; PARK1; SNCA
 Product Gene Name   

anti-SNCA antibody

[Similar Products]
 Product Synonym Gene Name    SNCA [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    127750
 3D Structure    ModBase 3D Structure for P37840
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Alpha-synuclein protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SNCA antibody

   Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer s disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
 Product Categories/Family for anti-SNCA antibody    Neuroscience
 Applications Tested/Suitable for anti-SNCA antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SNCA antibody    Recommended dilution: WB:1:500-2000
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 Western Blot (WB) of anti-SNCA antibody    All lanes: Alpha-synuclein antibody at 2ug/ml+293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 15,12,14 kDa
Observed band size: 55 kDa,118 kDa


anti-SNCA antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-SNCA antibody    Immunohistochemistry of paraffin-embedded human melanoma using MBS7002897 at dilution 1:100
anti-SNCA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product.
 NCBI GI #    4507109
 NCBI GeneID    6622
 NCBI Accession #    NP_000336.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000345.3 [Other Products]
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 UniProt Primary Accession #    P37840 [Other Products]
 UniProt Secondary Accession #    Q13701; Q4JHI3; Q6IAU6; A8K2A4 [Other Products]
 UniProt Related Accession #    P37840 [Other Products]
 Molecular Weight    13,109 Da [Similar Products]
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 NCBI Official Full Name    alpha-synuclein isoform NACP140
 NCBI Official Synonym Full Names    synuclein alpha
 NCBI Official Symbol    SNCA [Similar Products]
 NCBI Official Synonym Symbols   
PD1; NACP; PARK1; PARK4
[Similar Products]
 NCBI Protein Information    alpha-synuclein
 UniProt Protein Name    Alpha-synuclein
 UniProt Synonym Protein Names   
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
 Protein Family    Alpha-synuclein
 UniProt Gene Name    SNCA [Similar Products]
 UniProt Synonym Gene Names    NACP; PARK1; NACP [Similar Products]
 UniProt Entry Name    SYUA_HUMAN
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 NCBI Summary for SNCA    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
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 UniProt Comments for SNCA    SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: actin cytoskeleton; axon; cell cortex; cell junction; cytoplasm; cytosol; extracellular region; extracellular space; fibril; Golgi apparatus; growth cone; inclusion body; lysosome; membrane; mitochondrial respiratory chain complex I; mitochondrion; nuclear outer membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; platelet alpha granule membrane; ribosome; rough endoplasmic reticulum; synaptic vesicle; terminal button

Molecular Function: alpha-tubulin binding; beta-tubulin binding; calcium ion binding; caspase inhibitor activity; copper ion binding; dynein binding; fatty acid binding; ferrous iron binding; histone binding; identical protein binding; kinesin binding; magnesium ion binding; microtubule binding; oxidoreductase activity; phospholipase binding; phospholipid binding; phosphoprotein binding; protein binding; protein domain specific binding; protein N-terminus binding; tau protein binding; zinc ion binding

Biological Process: adult locomotory behavior; aging; behavioral response to cocaine; calcium ion homeostasis; caspase activation; cellular protein metabolic process; dopamine biosynthetic process; dopamine uptake; fatty acid metabolic process; fibril organization and biogenesis; microglial cell activation; mitochondrial membrane organization and biogenesis; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of dopamine metabolic process; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of histone acetylation; negative regulation of microtubule polymerization; negative regulation of monooxygenase activity; negative regulation of neuron apoptosis; negative regulation of norepinephrine uptake; negative regulation of protein amino acid phosphorylation; negative regulation of serotonin uptake; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transporter activity; neutral lipid metabolic process; organelle ATP synthesis coupled electron transport; phospholipid metabolic process; positive regulation of apoptosis; positive regulation of endocytosis; positive regulation of neurotransmitter secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of receptor recycling; positive regulation of release of sequestered calcium ion into cytosol; protein destabilization; receptor internalization; regulation of acyl-CoA biosynthetic process; regulation of dopamine secretion; regulation of excitatory postsynaptic membrane potential; regulation of glutamate secretion; regulation of locomotion; regulation of long-term neuronal synaptic plasticity; regulation of macrophage activation; response to drug; response to iron(II) ion; response to lipopolysaccharide; response to magnesium ion; synapse organization and biogenesis; synaptic vesicle endocytosis

Disease: Dementia, Lewy Body; Parkinson Disease 1, Autosomal Dominant; Parkinson Disease 4, Autosomal Dominant
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 Research Articles on SNCA    1. results establish that different types of crowded intracellular environments do not inherently promote alpha-synuclein oligomerization and, more generally, that intrinsic structural disorder is sustainable in mammalian cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SNCA antibodyPathways associated with anti-SNCA antibody
 Reference Product  PubMed Publications
 PARK2 antibody  >1029 publications with SNCA and PARK2
 MAPT antibody  >94 publications with SNCA and MAPT
 PARK7 antibody  >57 publications with SNCA and PARK7
 SNCAIP antibody  >33 publications with SNCA and SNCAIP
 SLC6A3 antibody  >27 publications with SNCA and SLC6A3
 APP antibody  >19 publications with SNCA and APP
 FYN antibody  >2 publications with SNCA and FYN
 UBC antibody  >1 publications with SNCA and UBC
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyloid Fiber Formation Pathway antibodies  Amyloid Fiber Formation Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
Diseases associated with anti-SNCA antibodyOrgans/Tissues associated with anti-SNCA antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1271 publications with SNCA and Nervous System Diseases
 Brain Diseases Antibodies  >1244 publications with SNCA and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1226 publications with SNCA and Neurodegenerative Diseases
 Movement Disorders Antibodies  >1103 publications with SNCA and Movement Disorders
 Parkinsonian Disorders Antibodies  >1019 publications with SNCA and Parkinsonian Disorders
 Parkinson Disease Antibodies  >964 publications with SNCA and Parkinson Disease
 Lewy Body Disease Antibodies  >301 publications with SNCA and Lewy Body Disease
 Disease Models, Animal Antibodies  >174 publications with SNCA and Disease Models, Animal
 Nerve Degeneration Antibodies  >174 publications with SNCA and Nerve Degeneration
 PARKINSON DISEASE 1, AUTOSOMAL DOMINANT Antibodies  >58 publications with SNCA and PARKINSON DISEASE 1, AUTOSOMAL DOMINANT
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1017 publications with SNCA and Nerve
 Brain Antibodies  >886 publications with SNCA and Brain
 Blood Antibodies  >93 publications with SNCA and Blood
 Embryonic Tissue Antibodies  >28 publications with SNCA and Embryonic Tissue
 Kidney Antibodies  >21 publications with SNCA and Kidney
 Heart Antibodies  >13 publications with SNCA and Heart
 Eye Antibodies  >12 publications with SNCA and Eye
 Liver Antibodies  >11 publications with SNCA and Liver
 Vascular Antibodies  >10 publications with SNCA and Vascular
 Skin Antibodies  >8 publications with SNCA and Skin
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