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Add To Compare List anti-SNCA antibody :: Rabbit Alpha-synuclein Polyclonal Antibody Catalog # MBS9600319 Unit / Price 0.1 mL / $270 +1 FREE 8GB USB 0.2 mL / $315 +1 FREE 8GB USB 5x0.2 mL / $1,245 +1 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Alpha-synuclein (SNCA), Polyclonal Antibody Popular Item Full Product Name Alpha-synuclein Antibody Product Synonym Names Alpha synuclein; Alpha-synuclein; Alpha-synuclein, isoform NACP140; alphaSYN; MGC105443; MGC110988; MGC127560; MGC64356; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid; Non A4 component of amyloid precursor; Non-A beta component of AD amyloid; Non-A-beta component of alzheimers disease amyloid, precursor of; Non-A4 component of amyloid precursor; Non-A4 component of amyloid, precursor of; OTTHUMP00000218549; OTTHUMP00000218551; OTTHUMP00000218552; OTTHUMP00000218553; OTTHUMP00000218554; PARK 1; PARK 4; PARK1; PARK4; Parkinson disease (autosomal dominant, Lewy body) 4; Parkinson disease familial 1; SNCA; Snca synuclein, alpha (non A4 component of amyloid precursor); SYN; Synuclein alpha; Synuclein alpha 140; Synuclein, alpha (non A4 component of amyloid precursor); SYUA_HUMAN Product Gene Name anti-SNCA antibody[Similar Products] Antibody/Peptide Pairs Synuclein alpha peptide (MBS9614872) is used for blocking the activity of Synuclein alpha antibody (MBS9600319) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP 3D Structure ModBase 3D Structure for P37840 Clonality Polyclonal Isotype IgG1 Host Rabbit Species Reactivity Human, Mouse, Rat Specificity Alpha-synuclein antibody detects endogenous levels of total Alpha-synuclein Purity/Purification The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin. Form/Format LiquidPhosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Concentration 1mg/ml (lot specific) Immunogen A synthesized peptide derived from human Alpha-synuclein Subcellular Location Cytoplasm, Cytosol. Membrane. Nucleus. Cell Junction, Synapse. Secreted. Membrane-bound in dopaminergic neurons. Tissue Specificity Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals. Conjugation Unconjugated Preparation and Storage Store at -20 degree C. Stable for 12 months from date of receipt. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Supply Chain Verification Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire. Other Notes Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-SNCA antibody Description: SNCA a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.Function: May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.Subunit Structure: Soluble monomer which can form filamentous aggregates. Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones.Post-translational Modifications: Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress.Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers. Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity). Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.Similarity: The 'non A-beta component of Alzheimer disease amyloid plaque' domain (NAC domain) is involved in fibrils formation. The middle hydrophobic region forms the core of the filaments. The C-terminus may regulate aggregation and determine the diameter of the filaments. Belongs to the synuclein family. Applications Tested/Suitable for anti-SNCA antibody Western Blot (WB), ELISA (EIA) Application Notes for anti-SNCA antibody WB: 1:500-1:3000 Western Blot (WB) of anti-SNCA antibody Western blot analysis on mouse brain cell lysate using Alpha-synuclein Antibody, The lane on the left is treated with the antigen-specific peptide. TOP NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product. NCBI GI # 4507109 NCBI GeneID 6622 NCBI Accession # NP_000336.1 [Other Products] NCBI GenBank Nucleotide # NM_000345.3 [Other Products] UniProt Primary Accession # P37840 [Other Products] UniProt Secondary Accession # Q13701; Q4JHI3; Q6IAU6; A8K2A4[Other Products] UniProt Related Accession # P37840[Other Products] Molecular Weight Observed: 18 kDaPredicted: 15 kDa TOP NCBI Official Full Name alpha-synuclein isoform NACP140 NCBI Official Synonym Full Names synuclein alpha NCBI Official Symbol SNCA [Similar Products] NCBI Official Synonym Symbols PD1; NACP; PARK1; PARK4 [Similar Products] NCBI Protein Information alpha-synuclein UniProt Protein Name Alpha-synuclein UniProt Synonym Protein Names Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP Protein Family Alpha-synuclein UniProt Gene Name SNCA [Similar Products] UniProt Synonym Gene Names NACP; PARK1; NACP [Similar Products] TOP NCBI Summary for SNCA Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016] TOP UniProt Comments for SNCA May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Research Articles on SNCA 1. These results suggest that alpha-syn increases FoxO3a expression as a result of its intrinsic ferrireductase activity. The results also suggest that FoxO3a plays a pivotal role in the toxicity of both Fe(II) and toxic alpha-syn species to neuronal cells TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-SNCA antibody Reference Product PubMed Publications SNCB antibody >74 publications with SNCA and SNCB MAPT antibody >64 publications with SNCA and MAPT SNCAIP antibody >31 publications with SNCA and SNCAIP PARK2 antibody >30 publications with SNCA and PARK2 APP antibody >16 publications with SNCA and APP SLC6A3 antibody >12 publications with SNCA and SLC6A3 MAPK1 antibody >5 publications with SNCA and MAPK1 TOR1A antibody >4 publications with SNCA and TOR1A BAD antibody >3 publications with SNCA and BAD SQSTM1 antibody >3 publications with SNCA and SQSTM1 Pathways associated with anti-SNCA antibody Products by Pathway Pathway Diagram Alpha-synuclein Signaling Pathway antibodies Alpha-synuclein Signaling Pathway Diagram Alzheimer's Disease Pathway antibodies Alzheimer's Disease Pathway Diagram Alzheimer's Disease Pathway antibodies Alzheimer's Disease Pathway Diagram Alzheimers Disease Pathway antibodies Alzheimers Disease Pathway Diagram Amyloids Pathway antibodies Amyloids Pathway Diagram Disease Pathway antibodies Disease Pathway Diagram EGFR1 Signaling Pathway antibodies EGFR1 Signaling Pathway Diagram Parkin-Ubiquitin Proteasomal System Pathway antibodies Parkin-Ubiquitin Proteasomal System Pathway Diagram Parkinson's Disease Pathway antibodies Parkinson's Disease Pathway Diagram Parkinsons Disease Pathway antibodies Parkinsons Disease Pathway Diagram Diseases associated with anti-SNCA antibody Disease Name Pubmed Publications Nervous System Diseases Antibodies >1049 publications with SNCA and Nervous System Diseases Brain Diseases Antibodies >1028 publications with SNCA and Brain Diseases Neurodegenerative Diseases Antibodies >1016 publications with SNCA and Neurodegenerative Diseases Movement Disorders Antibodies >896 publications with SNCA and Movement Disorders Parkinsonian Disorders Antibodies >829 publications with SNCA and Parkinsonian Disorders Parkinson Disease Antibodies >755 publications with SNCA and Parkinson Disease Lewy Body Disease Antibodies >270 publications with SNCA and Lewy Body Disease Nerve Degeneration Antibodies >160 publications with SNCA and Nerve Degeneration Disease Models, Animal Antibodies >127 publications with SNCA and Disease Models, Animal Drug Toxicity Antibodies >71 publications with SNCA and Drug Toxicity Organs/Tissues associated with anti-SNCA antibody Organ/Tissue Name Pubmed Publications Nerve Antibodies >986 publications with SNCA and Nerve Brain Antibodies >718 publications with SNCA and Brain Blood Antibodies >53 publications with SNCA and Blood Embryonic Tissue Antibodies >28 publications with SNCA and Embryonic Tissue Kidney Antibodies >19 publications with SNCA and Kidney Heart Antibodies >9 publications with SNCA and Heart Eye Antibodies >8 publications with SNCA and Eye Skin Antibodies >6 publications with SNCA and Skin Bone Antibodies >6 publications with SNCA and Bone Liver Antibodies >6 publications with SNCA and Liver TOP © 2006-24 MyBioSource.com. 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