NP_113736.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
78,888 Da
NCBI Official Full Name
amiloride-sensitive sodium channel subunit alpha
NCBI Official Synonym Full Names
sodium channel epithelial 1 alpha subunit
NCBI Official Synonym Symbols
NCBI Protein Information
amiloride-sensitive sodium channel subunit alpha
UniProt Protein Name
Amiloride-sensitive sodium channel subunit alpha
UniProt Synonym Protein Names
Alpha-NaCH; Epithelial Na(+) channel subunit alpha; Alpha-ENaC; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA
UniProt Synonym Gene Names
NCBI Summary for SCNN1a
acts as an epithelial sodium ion channel; regulates salt and fluid transport in the kidney [RGD, Feb 2006]
UniProt Comments for SCNN1a
ENaC-alpha: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. By aldosterone. Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. Activated by WNK1, WNK2, WNK3 and WNK4. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 4q42
Cellular Component: apical plasma membrane; cortical actin cytoskeleton; cytoplasm; cytosol; external side of plasma membrane; extracellular exosome; integral component of membrane; integral component of plasma membrane; membrane; sodium channel complex
Molecular Function: actin binding; ligand-gated sodium channel activity; sodium channel activity; WW domain binding
Biological Process: multicellular organismal water homeostasis; regulation of blood pressure; regulation of body fluid levels; sensory perception of taste; sodium ion homeostasis; sodium ion transport
Research Articles on SCNN1a
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Products associated with anti-SCNN1a antibody
Pathways associated with anti-SCNN1a antibody
Diseases associated with anti-SCNN1a antibody
Organs/Tissues associated with anti-SCNN1a antibody
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