NP_001030.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
74,270 Da
NCBI Official Full Name
amiloride-sensitive sodium channel subunit gamma
NCBI Official Synonym Full Names
sodium channel epithelial 1 gamma subunit
NCBI Official Synonym Symbols
PHA1; BESC3; ENaCg; SCNEG; ENaCgamma [Similar Products]
NCBI Protein Information
amiloride-sensitive sodium channel subunit gamma
UniProt Protein Name
Amiloride-sensitive sodium channel subunit gamma
UniProt Synonym Protein Names
Epithelial Na(+) channel subunit gamma; ENaCG; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG
UniProt Synonym Gene Names
NCBI Summary for SCNN1g
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]
UniProt Comments for SCNN1g
ENaC-gamma: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Defects in SCNN1G are a cause of Liddle syndrome (LIDDS). It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Defects in SCNN1G are the cause of bronchiectasis with or without elevated sweat chloride type 3 (BESC3). A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component: apical plasma membrane; external side of plasma membrane; extracellular exosome; integral component of plasma membrane; nucleolus; nucleoplasm; plasma membrane; sodium channel complex
Molecular Function: ion channel activity; ligand-gated sodium channel activity; protein binding; sodium channel activity; WW domain binding
Biological Process: excretion; multicellular organismal water homeostasis; response to stimulus; sensory perception of taste; sodium ion homeostasis; sodium ion transport
Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 3; Liddle Syndrome; Pseudohypoaldosteronism, Type I, Autosomal Recessive
Research Articles on SCNN1g
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Pathways associated with anti-SCNN1g antibody
Diseases associated with anti-SCNN1g antibody
Organs/Tissues associated with anti-SCNN1g antibody
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