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anti-Ab1-40 antibody :: Rabbit anti-Rat Amyloid Beta Peptide 1-40 (Ab1-40) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004399 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-Ab1-40 antibody
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $330 +1 FREE 8GB USB
1 mg  /  $785 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Amyloid Beta Peptide 1-40 (Ab1-40), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Amyloid Beta Peptide 1-40 (Ab1-40)

 Product Gene Name   

anti-Ab1-40 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SNKGAIIGLM VGGVV
 3D Structure    ModBase 3D Structure for P08592
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    The antibody is a rabbit polyclonal antibody raised against Ab1-40. It has been selected for its ability to recognize Ab1-40 in immunohistochemical staining and western blotting
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Ab1-40-OVA
 Accession No.    MBS2004399
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-Ab1-40 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-Ab1-40 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-Ab1-40 antibody    Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-1:5000
Optimal working dilutions must be determined by end user.
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NCBI/Uniprot data below describe general gene information for Ab1-40. It may not necessarily be applicable to this product.
 NCBI GI #    27436861
 NCBI GeneID    54226
 NCBI Accession #    NP_062161.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019288.2 [Other Products]
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 UniProt Primary Accession #    P08592 [Other Products]
 UniProt Secondary Accession #    Q547B7 [Other Products]
 UniProt Related Accession #    P08592 [Other Products]
 Molecular Weight    – Da
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 NCBI Official Full Name    amyloid-beta A4 protein
 NCBI Official Synonym Full Names    amyloid beta precursor protein
 NCBI Official Symbol    App [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    amyloid-beta A4 protein; amyloid beta A4 protein
 UniProt Protein Name    Amyloid-beta A4 protein
 UniProt Synonym Protein Names   
 UniProt Gene Name    App [Similar Products]
 UniProt Synonym Gene Names    APP; AG; S-APP-alpha; S-APP-beta; Beta-CTF; Abeta42; Abeta40; Alpha-CTF [Similar Products]
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 NCBI Summary for Ab1-40    activates voltage dependent calcium channels; may induce neuronal apoptosis [RGD, Feb 2006]
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 UniProt Comments for Ab1-40    APP: a cell surface receptor that influences neurite growth, neuronal adhesion and axonogenesis. Cleaved by secretases to form a number of peptides, some of which bind to the acetyltransferase complex Fe65/TIP60 to promote transcriptional activation. The Abeta peptide is released from the cell, its extracellular deposition and accumulation form the main components of amyloid plaques in Alzheimer's disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis. Can promote transcription activation through binding to Fe65-Tip60 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(O) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a RAGE-dependent pathway that activates p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, JIP1, SHC1 and, NUMB and DAB1. Binding to DAB1 inhibits its serine phosphorylation. Associates with microtubules in the presence of ATP and in a kinesin-dependent manner. Amyloid beta-42 binds nAChRA7 in hippocampal neurons. Beta-amyloid associates with HADH2. Soluble APP binds, via its N-terminal head, to FBLN1. Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex- opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra- striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. 10 isoforms of the human protein are produced by alternative splicing. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non- neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Belongs to the APP family.

Protein type: Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor

Chromosomal Location of Human Ortholog: 11q11

Cellular Component: apical part of cell; axon; cell surface; ciliary rootlet; clathrin-coated pit; COPII-coated ER to Golgi transport vesicle; cytoplasm; cytoplasmic vesicle; dendritic shaft; dendritic spine; endosome; extracellular exosome; extracellular space; Golgi apparatus; growth cone; integral component of membrane; intercellular junction; main axon; membrane; membrane raft; neuromuscular junction; neuron projection; nuclear envelope lumen; perinuclear region of cytoplasm; plasma membrane; receptor complex; rough endoplasmic reticulum; smooth endoplasmic reticulum; spindle midzone; synapse; synaptic vesicle; terminal bouton

Molecular Function: DNA binding; enzyme binding; heparin binding; identical protein binding; protease activator activity; protein binding; PTB domain binding; receptor binding; serine-type endopeptidase inhibitor activity; transition metal ion binding

Biological Process: adult locomotory behavior; amyloid fibril formation; astrocyte activation; astrocyte activation during immune response; axon cargo transport; axon midline choice point recognition; axonogenesis; cell adhesion; cellular copper ion homeostasis; cellular process; cellular response to amyloid-beta; cellular response to cAMP; cellular response to norepinephrine stimulus; cholesterol metabolic process; collateral sprouting in the absence of injury; dendrite development; endocytosis; extracellular matrix organization; forebrain development; ionotropic glutamate receptor signaling pathway; learning; learning and/or memory; locomotory behavior; mating behavior; microglia development; modulation of excitatory postsynaptic potential; mRNA polyadenylation; negative regulation of cell proliferation; negative regulation of endopeptidase activity; negative regulation of gene expression; negative regulation of low-density lipoprotein receptor activity; negative regulation of neuron differentiation; nervous system development; neuromuscular process controlling balance; neuron apoptosis; neuron projection development; neuron remodeling; Notch signaling pathway; positive regulation of amyloid fibril formation; positive regulation of amyloid-beta formation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of JNK cascade; positive regulation of long-term synaptic potentiation; positive regulation of mitotic cell cycle; positive regulation of peptidase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of protein binding; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of T cell migration; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of epidermal growth factor receptor activity; regulation of gene expression; regulation of long-term neuronal synaptic plasticity; regulation of multicellular organism growth; regulation of protein binding; regulation of synapse structure or activity; regulation of translation; response to lead ion; response to oxidative stress; smooth endoplasmic reticulum calcium ion homeostasis; suckling behavior; synapse organization; synaptic growth at neuromuscular junction; tumor necrosis factor production; visual learning

Disease: Alzheimer Disease
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 Research Articles on Ab1-40    1. Dynamic transport of Abeta aggregates is only observed between axon terminal and cell body. In addition to differential cellular uptake, more Abeta-peptide secretion is detected significantly from axons than from dendritic side.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Ab1-40 antibodyPathways associated with anti-Ab1-40 antibody
 Reference Product  PubMed Publications
 Apbb1 antibody  >90 publications with Ab1-40 and Apbb1
 Apbb3 antibody  >5 publications with Ab1-40 and Apbb3
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway antibodies  Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with anti-Ab1-40 antibodyOrgans/Tissues associated with anti-Ab1-40 antibody
 Disease Name  Pubmed Publications
 Alzheimer Disease Antibodies  >3486 publications with Ab1-40 and Alzheimer Disease
 Neurodegenerative Diseases Antibodies  >3339 publications with Ab1-40 and Neurodegenerative Diseases
 Neoplasms Antibodies  >470 publications with Ab1-40 and Neoplasms
 Inflammation Antibodies  >401 publications with Ab1-40 and Inflammation
 Cardiovascular Diseases Antibodies  >356 publications with Ab1-40 and Cardiovascular Diseases
 Necrosis Antibodies  >224 publications with Ab1-40 and Necrosis
 Memory Disorders Antibodies  >181 publications with Ab1-40 and Memory Disorders
 Brain Injuries Antibodies  >152 publications with Ab1-40 and Brain Injuries
 Brain Ischemia Antibodies  >145 publications with Ab1-40 and Brain Ischemia
 Learning Disorders Antibodies  >140 publications with Ab1-40 and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3806 publications with Ab1-40 and Brain
 Liver Antibodies  >428 publications with Ab1-40 and Liver
 Kidney Antibodies  >281 publications with Ab1-40 and Kidney
 Muscle Antibodies  >279 publications with Ab1-40 and Muscle
 Artery Antibodies  >156 publications with Ab1-40 and Artery
 Heart Antibodies  >154 publications with Ab1-40 and Heart
 Lung Antibodies  >133 publications with Ab1-40 and Lung
 Eye Antibodies  >92 publications with Ab1-40 and Eye
 Small Intestine Antibodies  >88 publications with Ab1-40 and Small Intestine
 Embryonic Tissue Antibodies  >84 publications with Ab1-40 and Embryonic Tissue
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