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Rabbit anti-Human Amyloid Fibrils (OC) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS805797 anti-Amyloid Fibrils (OC) antibody
Unit / Price
0.1 mL  /  $420 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Amyloid Fibrils (OC), Polyclonal Antibody

 Also Known As   

Amyloid Fibrils (OC) Antibody: Biotin
Rabbit Anti-Human Amyloid Fibrils (OC) Antibody Polyclonal

 Product Synonym Names    OC Antibody, Fibrils Antibody, Amyloid Oligomer ars Antibody, All Antibody, Amyloid beta A4 protein Antibody, ABPP Antibody, APPI Antibody, Alzheimer disease amyloid protein Antibody, Cerebral vascular amyloid peptide Antibody, PreA4 Antibody, Protease nexin-II Antibody, APP Antibody, A4 Antibody, AD Antibody
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrililar oligomers or natively folded proteins. Expected to detect in Mouse and Rat based on species homology.A 1:1000 dilution of MBS805797 was sufficient for detection of amyloid fibrils on PVDF membranes using
 Purity/Purification    Protein A Purified
 Form/Format    Protein A Purified
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 Conjugate    Biotin
 Certificate Of Analysis    ransferred fibrils by colorimetric dot blot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
 Storage Buffer    PBS, 50% glycerol, 0.09% sodium azide
 Immunogen    Fibrils prepared from human Abeta42 peptide
 Research Area(s)    Neuroscience; Cell Signaling; Cardiovascular System; Blood
 Cellular Localization    Membrane
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 Preparation and Storage    -20 degree C; 1 year + Avoid freeze/thaw cycle.
Shipping: Ships with Blue Ice.
 Other Notes    Small volumes of anti-Amyloid Fibrils (OC) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Amyloid Fibrils (OC) antibody

   Background Info: Recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrilllar oligomers or natively folded proteins.

Scientific Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-beta peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of alpha-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).
 Product Categories/Family for anti-Amyloid Fibrils (OC) antibody    Neuroscience
 Applications Tested/Suitable for anti-Amyloid Fibrils (OC) antibody   

Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB), Dot Blot (DB), Immunofluorescence (IF)

 Application Notes for anti-Amyloid Fibrils (OC) antibody    1:1000 (Dot Blot)
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Product References and Citations for anti-Amyloid Fibrils (OC) antibody

   1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547. 2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366. 3. Kayed R., et al. (2003) Science. 300(5618): 486-489.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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