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anti-APP antibody :: Goat Amyloid beta peptide Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422676
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Amyloid beta peptide (APP), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Amyloid beta peptide (aa1-16) Antibody

 Product Synonym Names    APP; amyloid beta (A4) precursor protein; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN2; OTTHUMP00000096096; PN-II; alzheimer disease amyloid protein; amyloid beta A4 protein; beta-amyloid peptide; cerebral vascular amyloid peptide; peptidase nexin-II; AAA antibody; ABETA antibody; ABPP antibody; AD1 antibody; alzheimer disease amyloid protein antibody; amyloid beta (A4) precursor protein antibody; amyloid beta A4 protein antibody; APPI antibody; beta-amyloid peptide antibody; cerebral vascular amyloid peptide antibody; CTFgamma antibody; CVAP antibody; OTTHUMP00000096096 antibody; peptidase nexin-II antibody; PN2 antibody; PN-II antibody; preA4 antibody; protease nexin-II antibody; APP antibody; Amyloid beta peptide (aa1-16); Amyloid beta peptide (aa1-16)
 Product Gene Name   

anti-APP antibody

[Similar Products]
 Antibody/Peptide Pairs    Amyloid beta peptide peptide (MBS427456) is used for blocking the activity of Amyloid beta peptide antibody (MBS422676)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DAEFRHDSGY EVHHQK
 OMIM    104300
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse; Expected from sequence similarity: Human, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence DAEFRHDSGYEVHHQK-C, from the N Terminus of the protein sequence according to NP_000475.1; NP_958816.1; NP_958817.1; NP_001129601.1; NP_001129602.1.
 Epitope    N Terminus
 Note    This antibody is expected to recognize all reported isoforms of APP (NP_000475.1; NP_958816.1; NP_958817.1; NP_001129601.1; NP_001129602.1) and to recognize all lengths of the Amyloid beta peptide.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-APP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-APP antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-APP antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 75kDa band observed in Human Brain (Cerebral and Frontal cortex) lysates and in Mouse adult and fetal Brain lysates (calculated MW of 78.7kDa according to NP_958817.1 and 72. 6 according to NP_001129601.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-APP antibody    (1ug/ml) staining of Human Cerebral Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-APP antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for APP. It may not necessarily be applicable to this product.
 NCBI GI #    4502167
 NCBI GeneID    351
 NCBI Accession #    NP_000475.1 [Other Products]
 NCBI Related Accession #    NP_958816.1; NP_958817.1; NP_001129601.1; NP_001129602.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000484.3 [Other Products]
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 UniProt Secondary Accession #    P09000; P78438; Q13764; Q13778; Q13793; Q16011; B2R5V1; B4DII8; D3DSD1; D3DSD2; D3DSD3 [Other Products]
 UniProt Related Accession #    P05067 [Other Products]
 Molecular Weight    84,521 Da
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 NCBI Official Full Name    amyloid beta A4 protein isoform a
 NCBI Official Synonym Full Names    amyloid beta precursor protein
 NCBI Official Symbol    APP [Similar Products]
 NCBI Official Synonym Symbols   
AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma
[Similar Products]
 NCBI Protein Information    amyloid beta A4 protein
 UniProt Protein Name    Amyloid beta A4 protein
 UniProt Synonym Protein Names   
ABPP; APPI; APP
 Protein Family    Amyloid beta A4 protein
 UniProt Gene Name    APP [Similar Products]
 UniProt Synonym Gene Names    A4; AD1; APP; CVAP; PN-II; S-APP-alpha; S-APP-beta; AICD-59; AID(59); AICD-57; AID(57); AICD-50; AID(50) [Similar Products]
 UniProt Entry Name    A4_HUMAN
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 NCBI Summary for APP    This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
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 UniProt Comments for APP    APP: a cell surface receptor that influences neurite growth, neuronal adhesion and axonogenesis. Cleaved by secretases to form a number of peptides, some of which bind to the acetyltransferase complex Fe65/TIP60 to promote transcriptional activation. The Abeta peptide is released from the cell, its extracellular deposition and accumulation form the main components of amyloid plaques in Alzheimer's disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis. Can promote transcription activation through binding to Fe65-Tip60 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(O) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a RAGE-dependent pathway that activates p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, JIP1, SHC1 and, NUMB and DAB1. Binding to DAB1 inhibits its serine phosphorylation. Associates with microtubules in the presence of ATP and in a kinesin-dependent manner. Amyloid beta-42 binds nAChRA7 in hippocampal neurons. Beta-amyloid associates with HADH2. Soluble APP binds, via its N-terminal head, to FBLN1. Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex- opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra- striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. 10 isoforms of the human protein are produced by alternative splicing. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non- neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Belongs to the APP family.

Protein type: Apoptosis; Receptor, misc.; Transcription factor; Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 21q21.3

Cellular Component: apical part of cell; axon; cell surface; ciliary rootlet; coated pit; cytoplasm; cytosol; dendritic shaft; dendritic spine; endosome; ER to Golgi transport vesicle; extracellular region; extracellular space; Golgi apparatus; integral to membrane; integral to plasma membrane; intercellular junction; intracellular membrane-bound organelle; lipid raft; neuromuscular junction; nuclear envelope lumen; perinuclear region of cytoplasm; plasma membrane; receptor complex; rough endoplasmic reticulum; smooth endoplasmic reticulum; spindle midzone; synapse; terminal button; trans-Golgi network membrane

Molecular Function: acetylcholine receptor binding; DNA binding; enzyme binding; heparin binding; identical protein binding; protease activator activity; protein binding; PTB domain binding; receptor binding; serine-type endopeptidase inhibitor activity; transition metal ion binding

Biological Process: adult locomotory behavior; antibacterial humoral response; antifungal humoral response; axon cargo transport; axon midline choice point recognition; axonogenesis; cell adhesion; cellular copper ion homeostasis; cellular process; cellular protein metabolic process; cholesterol metabolic process; collateral sprouting in the absence of injury; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; dendrite development; endocytosis; extracellular matrix organization and biogenesis; forebrain development; innate immune response; ionotropic glutamate receptor signaling pathway; locomotory behavior; mating behavior; mRNA polyadenylation; negative regulation of neuron differentiation; neurite development; neuromuscular process controlling balance; neuron apoptosis; neuron remodeling; Notch signaling pathway; platelet degranulation; positive regulation of mitotic cell cycle; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of epidermal growth factor receptor activity; regulation of multicellular organism growth; regulation of protein binding; regulation of synapse structure and activity; regulation of translation; response to lead ion; response to oxidative stress; response to yeast; smooth endoplasmic reticulum calcium ion homeostasis; suckling behavior; synaptic growth at neuromuscular junction; visual learning

Disease: Alzheimer Disease
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 Research Articles on APP    1. variants in FRA10AC1 associated with CSF Abeta1-42 level passing the genome-wide significance threshold, were identified.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APP antibodyPathways associated with anti-APP antibody
 Reference Product  PubMed Publications
 BACE1 antibody  >1359 publications with APP and BACE1
 PSEN1 antibody  >831 publications with APP and PSEN1
 APBB1 antibody  >116 publications with APP and APBB1
 TGFB1 antibody  >26 publications with APP and TGFB1
 SNCA antibody  >21 publications with APP and SNCA
 KAT5 antibody  >19 publications with APP and KAT5
 CASP6 antibody  >10 publications with APP and CASP6
 MAPK8IP1 antibody  >10 publications with APP and MAPK8IP1
 NAE1 antibody  >3 publications with APP and NAE1
 MAPK9 antibody  >1 publications with APP and MAPK9
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyloid Fiber Formation Pathway antibodies  Amyloid Fiber Formation Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
Diseases associated with anti-APP antibodyOrgans/Tissues associated with anti-APP antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5979 publications with APP and Nervous System Diseases
 Brain Diseases Antibodies  >5712 publications with APP and Brain Diseases
 Alzheimer Disease Antibodies  >5662 publications with APP and Alzheimer Disease
 Neurodegenerative Diseases Antibodies  >5283 publications with APP and Neurodegenerative Diseases
 Dementia Antibodies  >5278 publications with APP and Dementia
 Disease Models, Animal Antibodies  >1982 publications with APP and Disease Models, Animal
 Plaque, Amyloid Antibodies  >1336 publications with APP and Plaque, Amyloid
 Inflammation Antibodies  >710 publications with APP and Inflammation
 Amyloidosis Antibodies  >441 publications with APP and Amyloidosis
 Memory Disorders Antibodies  >429 publications with APP and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6122 publications with APP and Brain
 Blood Antibodies  >2022 publications with APP and Blood
 Nerve Antibodies  >1238 publications with APP and Nerve
 Liver Antibodies  >692 publications with APP and Liver
 Vascular Antibodies  >675 publications with APP and Vascular
 Intestine Antibodies  >382 publications with APP and Intestine
 Muscle Antibodies  >358 publications with APP and Muscle
 Kidney Antibodies  >353 publications with APP and Kidney
 Heart Antibodies  >273 publications with APP and Heart
 Bone Antibodies  >200 publications with APP and Bone
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