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anti-AUP1 antibody :: Rabbit anti-Human, Pig Ancient Ubiquitous Protein 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2032556 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $340 +1 FREE 8GB USB
1 mg  /  $800 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ancient Ubiquitous Protein 1 (AUP1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Ancient Ubiquitous Protein 1 (AUP1) Polyclonal Antibody

 Product Gene Name   

anti-AUP1 antibody

[Similar Products]
 Matching Pairs    Antibody: Ancient Ubiquitous Protein 1 (MBS2032556)
Antigen: Ancient Ubiquitous Protein 1 (MBS2033255)
 Matching Pairs    Unconjugated Antibody: Ancient Ubiquitous Protein 1 (MBS2032556)
APC-CY7 Conjugated Antibody: Ancient Ubiquitous Protein 1 (AUP1) (MBS2064751)
 Matching Pairs    Unconjugated Antibody: Ancient Ubiquitous Protein 1 (MBS2032556)
PE Conjugated Antibody: Ancient Ubiquitous Protein 1 (AUP1) (MBS2064752)
 Matching Pairs    Unconjugated Antibody: Ancient Ubiquitous Protein 1 (MBS2032556)
APC-CY7 Conjugated Antibody: Ancient Ubiquitous Protein 1 (AUP1) (MBS2064753)
 Matching Pairs    Unconjugated Antibody: Ancient Ubiquitous Protein 1 (MBS2032556)
Cy3 Conjugated Antibody: Ancient Ubiquitous Protein 1 (AUP1) (MBS2064754)
 Matching Pairs    Unconjugated Antibody: Ancient Ubiquitous Protein 1 (MBS2032556)
FITC Conjugated Antibody: Ancient Ubiquitous Protein 1 (AUP1) (MBS2064755)
 Matching Pairs    Unconjugated Antibody: Ancient Ubiquitous Protein 1 (MBS2032556)
HRP Conjugated Antibody: Ancient Ubiquitous Protein 1 (AUP1) (MBS2064756)
 Matching Pairs    Unconjugated Antibody: Ancient Ubiquitous Protein 1 (MBS2032556)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Ancient Ubiquitous Protein 1 (MBS2032556)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: Ancient Ubiquitous Protein 1 (MBS2032556)
Biotin Conjugated Antibody: Ancient Ubiquitous Protein 1 (AUP1) (MBS2094385)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF100754 mRNA
 3D Structure    ModBase 3D Structure for Q9Y679
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Pig
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 Specificity    The antibody is a rabbit polyclonal antibody raised against AUP1. It has been selected for its ability to recognize AUP1 in immunohistochemical staining and western blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4 containing 0.02% NaN3, 50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunoglobulin Type    IgG
 Conjugate    No Conjugate
 Organism Species    Human
 Fragment    AUP1 (Val201~Asp410)
 Quality Control    Content: The quality control contains recombinant AUP1 (Val201~Asp410) disposed in loading buffer.
Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate.
5uL per well when used in enhanced chemilumescent (ECL).
Note: The quality control is specifically manufactured as the positive control.Not used for other purposes.
Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2064753
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-AUP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-AUP1 antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-AUP1 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-AUP1 antibody    Western Blot: 1:50-400
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) Knockout Verification of anti-AUP1 antibody    Knockout Verification: Lane 1: Wild-type Jurkat cell lysate; Lane 2: AUP1 knockout Jurkat cell lysate; Predicted MW: 53,46,41kd Observed MW: 45kd Primary Ab: 1ug/ml Rabbit Anti-Human AUP1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-AUP1 antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-AUP1 antibody    Western Blot; Sample: Human Serum; Primary Ab: 1ug/ml Rabbit Anti-Human AUP1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-AUP1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-AUP1 antibody    Western Blot; Sample: Recombinant protein.
anti-AUP1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-AUP1 antibody    DAB staining on fromalin fixed paraffin- embedded Kidney tissue)
anti-AUP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-AUP1 antibody    DAB staining on IHC-P; Samples: Human Stomach Tissue)
anti-AUP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for AUP1. It may not necessarily be applicable to this product.
 NCBI GI #    31712030
 NCBI GeneID    550
 NCBI Accession #    NP_853553.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_181575.4 [Other Products]
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 UniProt Primary Accession #    Q9Y679 [Other Products]
 UniProt Secondary Accession #    Q9H866; Q9UNQ6; Q9Y685; C0H5W8 [Other Products]
 UniProt Related Accession #    Q9Y679 [Other Products]
 Molecular Weight    41,385 Da
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 NCBI Official Full Name    ancient ubiquitous protein 1
 NCBI Official Synonym Full Names    AUP1, lipid droplet regulating VLDL assembly factor
 NCBI Official Symbol    AUP1 [Similar Products]
 NCBI Protein Information    ancient ubiquitous protein 1
 UniProt Protein Name    Ancient ubiquitous protein 1
 Protein Family    Ancient ubiquitous protein
 UniProt Gene Name    AUP1 [Similar Products]
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 NCBI Summary for AUP1    The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
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 UniProt Comments for AUP1    AUP1: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Belongs to the AUP1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Transferase

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: extracellular exosome; Hrd1p ubiquitin ligase ERAD-L complex; integral component of endoplasmic reticulum membrane; membrane

Molecular Function: protein binding; ubiquitin binding

Biological Process: ER-associated protein catabolic process; regulation of catalytic activity; retrograde protein transport, ER to cytosol
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 Research Articles on AUP1    1. AUP1 may be a crucial factor in hepatic apoB100 quality control, determining the rate at which apoB100 is degraded or lipidated to enable VLDL particle assembly and secretion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-AUP1 antibodyOrgans/Tissues associated with anti-AUP1 antibody
 Disease Name  Pubmed Publications
 Neuromuscular Diseases Antibodies  >1 publications with AUP1 and Neuromuscular Diseases
 Death Antibodies  >1 publications with AUP1 and Death
 Carcinoma, Hepatocellular Antibodies  >1 publications with AUP1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with AUP1 and Muscle
 Blood Antibodies  >2 publications with AUP1 and Blood
 Liver Antibodies  >2 publications with AUP1 and Liver
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