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anti-AR antibody :: Goat Androgen Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421183
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Androgen Receptor (AR), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Androgen Receptor Antibody

 Product Synonym Names    AR; androgen receptor; dihydrotestosterone receptor; KD; AIS; TFM; DHTR; SBMA; NR3C4; SMAX1; HUMARA; HYSP1; androgen receptor; dihydrotestosterone receptor; RP11-383C12.1; androgen receptor antibody; dihydrotestosterone receptor antibody; AR antibody; KD antibody; AIS antibody; TFM antibody; DHTR antibody; SBMA antibody; NR3C4 antibody; SMAX1 antibody; HUMARA antibody; HYSP1 antibody; androgen receptor antibody; dihydrotestosterone receptor antibody; RP11-383C12.1 antibody; Androgen Receptor; Androgen Receptor
 Product Gene Name   

anti-AR antibody

[Similar Products]
 Antibody/Peptide Pairs    Androgen Receptor peptide (MBS426484) is used for blocking the activity of Androgen Receptor antibody (MBS421183)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    EVQLGLGRVY PRPPSC
 OMIM    300068
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence EVQLGLGRVYPRPPSC, from the N Terminus of the protein sequence according to NP_000035.2.
 Epitope    N Terminus
 Note    This antibody is expected to recognize isoform 1 (NP_000035.2) only.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-AR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-AR antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

 Application Notes for anti-AR antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Human Prostate shows nuclear staining in the secretory cells of the gland. Recommended concentration, 2-3ug/ml.
Western Blot: Approx 95kDa band observed in Human Brain and Human Heart lysates (calculated MW of 99kDa according to NP_000035). Recommended concentration: 0.3-2ug/ml.
Chromatin Immunoprecipitation: A six-fold increased presence of the FKBP5 locus observed when comparing the precipitations using this item with non-specific goat IgG to bring down Androgen Receptor in a chromatin lysate from DHT-stimulated HEC50 cells.
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 Western Blot (WB) of anti-AR antibody    Staining of Human Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-AR antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-AR antibody    (2ug/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-AR antibody Immunohistochemistry (IHC) (IHC) image
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 Testing Data of anti-AR antibody    ChIP of 2ug with 1ug DHT-treated HEC50 chromatin using the Chromatrap spin column sonication kit (Protein G) measuring FKBP5 enrichment.
anti-AR antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for AR. It may not necessarily be applicable to this product.
 NCBI GI #    21322252
 NCBI GeneID    367
 NCBI Accession #    NP_000035.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000044.3 [Other Products]
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 UniProt Secondary Accession #    Q9UD95; A0A0B4J1T2; A2RUN2; B1AKD7; C0JKD3; C0JKD4; E7EVX6 [Other Products]
 UniProt Related Accession #    P10275 [Other Products]
 Molecular Weight    67,659 Da
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 NCBI Official Full Name    androgen receptor isoform 1
 NCBI Official Synonym Full Names    androgen receptor
 NCBI Official Symbol    AR [Similar Products]
 NCBI Official Synonym Symbols   
KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA
[Similar Products]
 NCBI Protein Information    androgen receptor
 UniProt Protein Name    Androgen receptor
 UniProt Synonym Protein Names   
Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
 Protein Family    Allatostatin
 UniProt Gene Name    AR [Similar Products]
 UniProt Synonym Gene Names    DHTR; NR3C4 [Similar Products]
 UniProt Entry Name    ANDR_HUMAN
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 NCBI Summary for AR    The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AR    AR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Chromosomal Location of Human Ortholog: Xq12

Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; protein complex

Molecular Function: androgen binding; androgen receptor activity; ATPase binding; beta-catenin binding; chromatin binding; DNA binding; enzyme binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; receptor binding; transcription factor activity; transcription factor binding; zinc ion binding

Biological Process: activation of NF-kappaB transcription factor; androgen receptor signaling pathway; cell growth; cell proliferation; cell-cell signaling; intracellular receptor-mediated signaling pathway; negative regulation of cell proliferation; negative regulation of integrin biosynthetic process; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of integrin biosynthetic process; positive regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription, DNA-dependent; prostate gland development; protein oligomerization; sex differentiation; signal transduction; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transport

Disease: Androgen Insensitivity Syndrome; Androgen Insensitivity, Partial; Hypospadias 1, X-linked; Prostate Cancer; Spinal And Bulbar Muscular Atrophy, X-linked 1
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 Research Articles on AR    1. Analyses predicted that most of the miRNA regulation of the Androgen Receptor (AR) gene would target an extended 6 kb 3' UTR of AR that is much longer than currently used in miRNA target prediction programs.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AR antibodyPathways associated with anti-AR antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >840 publications with AR and CTNNB1
 SRC antibody  >776 publications with AR and SRC
 TMPRSS2 antibody  >145 publications with AR and TMPRSS2
 NCOA1 antibody  >55 publications with AR and NCOA1
 NCOA2 antibody  >54 publications with AR and NCOA2
 KLK3 antibody  >44 publications with AR and KLK3
 NCOR1 antibody  >33 publications with AR and NCOR1
 NCOA3 antibody  >31 publications with AR and NCOA3
 RNF14 antibody  >17 publications with AR and RNF14
 HSP90AA1 antibody  >4 publications with AR and HSP90AA1
 Products by Pathway  Pathway Diagram
 Activated PKN1 Stimulates Transcription Of AR (androgen Receptor) Regulated Genes KLK2 And KLK3 Pathway antibodies  Activated PKN1 Stimulates Transcription Of AR (androgen Receptor) Regulated Genes KLK2 And KLK3 Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
Diseases associated with anti-AR antibodyOrgans/Tissues associated with anti-AR antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >9204 publications with AR and Nervous System Diseases
 Inflammation Antibodies  >6200 publications with AR and Inflammation
 Heart Diseases Antibodies  >4653 publications with AR and Heart Diseases
 Necrosis Antibodies  >3618 publications with AR and Necrosis
 Prostatic Neoplasms Antibodies  >3500 publications with AR and Prostatic Neoplasms
 Kidney Diseases Antibodies  >2165 publications with AR and Kidney Diseases
 Hypertension Antibodies  >1643 publications with AR and Hypertension
 Breast Neoplasms Antibodies  >1504 publications with AR and Breast Neoplasms
 Liver Diseases Antibodies  >1457 publications with AR and Liver Diseases
 Hypertrophy Antibodies  >1360 publications with AR and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >18242 publications with AR and Bone
 Muscle Antibodies  >14261 publications with AR and Muscle
 Skin Antibodies  >9904 publications with AR and Skin
 Heart Antibodies  >7402 publications with AR and Heart
 Vascular Antibodies  >6155 publications with AR and Vascular
 Brain Antibodies  >5840 publications with AR and Brain
 Prostate Antibodies  >5241 publications with AR and Prostate
 Kidney Antibodies  >4030 publications with AR and Kidney
 Liver Antibodies  >3635 publications with AR and Liver
 Lung Antibodies  >2912 publications with AR and Lung
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