NP_000035.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
androgen receptor isoform 1
NCBI Official Synonym Full Names
androgen receptor
NCBI Official Synonym Symbols
KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA [Similar Products]
NCBI Protein Information
androgen receptor
UniProt Protein Name
Androgen receptor
UniProt Synonym Protein Names
Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
UniProt Synonym Gene Names
UniProt Entry Name
ANDR_HUMAN
NCBI Summary for AR
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for AR
AR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: Xq12
Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; protein complex
Molecular Function: androgen binding; androgen receptor activity; ATPase binding; beta-catenin binding; chromatin binding; DNA binding; enzyme binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; receptor binding; transcription factor activity; transcription factor binding; zinc ion binding
Biological Process: activation of NF-kappaB transcription factor; androgen receptor signaling pathway; cell growth; cell proliferation; cell-cell signaling; intracellular receptor-mediated signaling pathway; negative regulation of cell proliferation; negative regulation of integrin biosynthetic process; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of integrin biosynthetic process; positive regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription, DNA-dependent; prostate gland development; protein oligomerization; sex differentiation; signal transduction; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transport
Disease: Androgen Insensitivity Syndrome; Androgen Insensitivity, Partial; Hypospadias 1, X-linked; Prostate Cancer; Spinal And Bulbar Muscular Atrophy, X-linked 1
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Products associated with anti-AR antibody
Pathways associated with anti-AR antibody
Diseases associated with anti-AR antibody
Organs/Tissues associated with anti-AR antibody
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