NP_060516.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,506 Da
NCBI Official Full Name
angiogenic factor with G patch and FHA domains 1
NCBI Official Synonym Full Names
angiogenic factor with G-patch and FHA domains 1
NCBI Official Synonym Symbols
VG5Q; GPATC7; GPATCH7; HSU84971; HUS84971 [Similar Products]
NCBI Protein Information
angiogenic factor with G patch and FHA domains 1
UniProt Protein Name
Angiogenic factor with G patch and FHA domains 1
UniProt Synonym Protein Names
Angiogenic factor VG5Q; hVG5Q; G patch domain-containing protein 7; Vasculogenesis gene on 5q protein
UniProt Synonym Gene Names
NCBI Summary for AGGF1
This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]
UniProt Comments for AGGF1
AGGF1: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. Defects in AGGF1 are a cause of Klippel-Trenaunay syndrome (KTS). KTS is a congenital disease characterized by malformations of capillary (98% of KTS patients), venous (72%) and lymphatic (11%) vessels, and bony and soft tissue hypertrophy that leads to large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; RNA processing
Chromosomal Location of Human Ortholog: 5q13.3
Cellular Component: cytoplasm; extracellular region; nuclear speck; perinuclear region of cytoplasm
Molecular Function: protein binding; RNA binding
Biological Process: cell adhesion; mRNA processing; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; regulation of RNA splicing; RNA processing; vasculogenesis
Disease: Klippel-trenaunay-weber Syndrome
Research Articles on AGGF1
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Products associated with anti-AGGF1 antibody
Diseases associated with anti-AGGF1 antibody
Organs/Tissues associated with anti-AGGF1 antibody
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