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anti-ANGPT2 antibody :: Angiopoietin 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS177699
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Angiopoietin 2 (ANGPT2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Angiopoietin 2 Antibody

 Product Synonym Names    Angiopoietin-2; AGPT 2; Agpt2; ANG 2; ANG-2; ANG2; ANG2; Angiopoietin 2a; Angiopoietin 2B; Angiopoietin-2; Angiopoietin2; ANGP2_HUMAN; ANGPT 2; ANGPT2; ANGPT2; Tie2 ligand; angiopoietin 2
 Product Gene Name   

anti-ANGPT2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601922
 3D Structure    ModBase 3D Structure for O15123
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 Clonality    Polyclonal
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen Affinity Purified
 Form/Format    Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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 Immunogen    E Coli-derived human Angiopoietin 2 recombinant protein (Position: Y19-N348). Human Angiopoietin 2 shares 84% and 85% amino acid (aa) sequences identity with mouse and rat Angiopoietin 2, respectively.
 Ig Type    Rabbit IgG
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ANGPT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ANGPT2 antibody

   Description: Rabbit IgG polyclonal antibody for Angiopoietin-2(ANGPT2) detection. Tested with IHC-P in Human;Mouse;Rat.

Background: ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. It is mapped to 8p23.1. ANGPT2 is a naturally occurring antagonist of ANG1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. ANGPT2 was significantly increased in plasma and alveolar edema fluid in adults with acute lung injury compared to controls or patients with hydrostatic pulmonary edema, tracheal. ANGPT2 was also significantly increased in neonates with respiratory distress syndrome who developed bronchopulmonary edema. It is also a mediator of epithelial necrosis with an important role in hyperoxic acute lung injury and pulmonary edema.
 Applications Tested/Suitable for anti-ANGPT2 antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-ANGPT2 antibody    Immunohistochemistry:
Concentration: 0.5-1 ug/ml
Tested Species: Hu, Ms, Rat
Antigen Retrieval: By Heat
Tested Species: In house tested species with positive results.
By Heat: Boiling paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
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 Immunohistochemistry (IHC) of anti-ANGPT2 antibody    Anti-Angiopoietin 2 Picoband antibody, -1.JPG
IHC(P): Human Placenta Tissue
anti-ANGPT2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ANGPT2 antibody    Anti-Angiopoietin 2 Picoband antibody, -2.JPG
IHC(P): Rat Intestine Tissue
anti-ANGPT2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ANGPT2 antibody    Anti-Angiopoietin 2 Picoband antibody, -3.JPG
IHC(P): Mouse Intestine Tissue
anti-ANGPT2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ANGPT2. It may not necessarily be applicable to this product.
 NCBI GI #    169646749
 NCBI GeneID    285
 NCBI Accession #    NP_001112359.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001118887.1 [Other Products]
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 UniProt Primary Accession #    O15123 [Other Products]
 UniProt Secondary Accession #    Q9NRR7; Q9P2Y7; A0AV38; A8K205; B7ZLM7 [Other Products]
 UniProt Related Accession #    O15123 [Other Products]
 Molecular Weight    56,848 Da [Similar Products]
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 NCBI Official Full Name    angiopoietin-2 isoform b
 NCBI Official Synonym Full Names    angiopoietin 2
 NCBI Official Symbol    ANGPT2 [Similar Products]
 NCBI Official Synonym Symbols   
ANG2; AGPT2
[Similar Products]
 NCBI Protein Information    angiopoietin-2
 UniProt Protein Name    Angiopoietin-2
 Protein Family    Angiopoietin
 UniProt Gene Name    ANGPT2 [Similar Products]
 UniProt Synonym Gene Names    ANG-2 [Similar Products]
 UniProt Entry Name    ANGP2_HUMAN
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 NCBI Summary for ANGPT2    The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ANGPT2    ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: cell projection; extracellular region; extracellular space; nucleus; plasma membrane

Molecular Function: metal ion binding; protein binding; receptor binding; receptor tyrosine kinase binding

Biological Process: angiogenesis; germ cell development; leukocyte migration; maternal process involved in pregnancy; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of positive chemotaxis; organ regeneration; positive regulation of angiogenesis; response to activity; response to glucose stimulus; response to hypoxia; response to mechanical stimulus; response to organic cyclic substance; response to radiation; signal transduction; Tie receptor signaling pathway
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Product References and Citations for anti-ANGPT2 antibody

   1. Bhandari, V., Choo-Wing, R., Lee, C. G., Zhu, Z., Nedrelow, J. H., Chupp, G. L., Zhang, X., Matthay, M. A., Ware, L. B., Homer, R. J., Lee, P. J., Geick, A., de Fougerolles, A. R., Elias, J. A. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nature Med. 12: 1286-1293, 2006. 2. Kim, I., Kim, J.-H., Ryu, Y. S., Jung, S. H., Nah, J. J., Koh, G. Y. Characterization and expression of a novel alternatively spliced human angiopoietin-2. J. Biol. Chem. 275: 18550-18556, 2000. 3. Cheung AH, Stewart RJ, Marsden PA (Jun 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". Genomics 48 (3): 389-91. 4. Fiedler, Ulrike; Krissl Tanja, Koidl Stefanie, Weiss Cornelia, Koblizek Thomas, Deutsch Urban, Martiny-Baron Georg, Marmé Dieter, Augustin Hellmut G (Jan 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. (United States) 278 (3): 1721-7.
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 Research Articles on ANGPT2    1. Serum and urine TNF-alpha, IL-18 and 8-OHdG levels increased significantly with the degree of albuminuria, and were positively correlated with increased Ang-2
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ANGPT2 antibodyPathways associated with anti-ANGPT2 antibody
 Reference Product  PubMed Publications
 ANGPT1 antibody  >360 publications with ANGPT2 and ANGPT1
 VEGFA antibody  >184 publications with ANGPT2 and VEGFA
 FGF2 antibody  >69 publications with ANGPT2 and FGF2
 TEK antibody  >52 publications with ANGPT2 and TEK
 TIE1 antibody  >42 publications with ANGPT2 and TIE1
 KDR antibody  >39 publications with ANGPT2 and KDR
 FLT1 antibody  >26 publications with ANGPT2 and FLT1
 FOXO1 antibody  >10 publications with ANGPT2 and FOXO1
 ETS1 antibody  >7 publications with ANGPT2 and ETS1
 FLT4 antibody  >2 publications with ANGPT2 and FLT4
 Products by Pathway  Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Tie2 Signaling Pathway antibodies  Tie2 Signaling Pathway Diagram
Diseases associated with anti-ANGPT2 antibodyOrgans/Tissues associated with anti-ANGPT2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >302 publications with ANGPT2 and Cardiovascular Diseases
 Inflammation Antibodies  >277 publications with ANGPT2 and Inflammation
 Disease Models, Animal Antibodies  >190 publications with ANGPT2 and Disease Models, Animal
 Necrosis Antibodies  >133 publications with ANGPT2 and Necrosis
 Adenocarcinoma Antibodies  >109 publications with ANGPT2 and Adenocarcinoma
 Liver Diseases Antibodies  >88 publications with ANGPT2 and Liver Diseases
 Kidney Diseases Antibodies  >88 publications with ANGPT2 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >87 publications with ANGPT2 and Neoplasms, Experimental
 Heart Diseases Antibodies  >86 publications with ANGPT2 and Heart Diseases
 Neoplasm Metastasis Antibodies  >82 publications with ANGPT2 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1491 publications with ANGPT2 and Vascular
 Muscle Antibodies  >195 publications with ANGPT2 and Muscle
 Lung Antibodies  >169 publications with ANGPT2 and Lung
 Brain Antibodies  >159 publications with ANGPT2 and Brain
 Embryonic Tissue Antibodies  >152 publications with ANGPT2 and Embryonic Tissue
 Liver Antibodies  >135 publications with ANGPT2 and Liver
 Kidney Antibodies  >125 publications with ANGPT2 and Kidney
 Eye Antibodies  >109 publications with ANGPT2 and Eye
 Placenta Antibodies  >79 publications with ANGPT2 and Placenta
 Bone Marrow Antibodies  >76 publications with ANGPT2 and Bone Marrow
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