NP_031452.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,576 Da
NCBI Official Full Name
angiopoietin-2
NCBI Official Synonym Full Names
angiopoietin 2
NCBI Protein Information
angiopoietin-2
UniProt Protein Name
Angiopoietin-2
UniProt Synonym Gene Names
UniProt Entry Name
ANGP2_MOUSE
NCBI Summary for Agpt2
This gene encodes an endothelial cell (EC)-derived regulator of angiogenesis and ligand for endothelial-specific receptor tyrosine kinase. The encoded protein acts as an anti-apoptotic factor for stressed ECs and a proapoptotic factor for resting ECs. [provided by RefSeq, Jan 2013]
UniProt Comments for Agpt2
ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: cell projection; extracellular region; extracellular space; nucleus; plasma membrane
Molecular Function: metal ion binding; protein binding; receptor tyrosine kinase binding; vascular endothelial growth factor receptor binding
Biological Process: angiogenesis; blood vessel morphogenesis; blood vessel remodeling; cell differentiation; endoderm development; hemopoiesis; multicellular organismal development; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of positive chemotaxis; positive regulation of angiogenesis; regulation of angiogenesis; Tie receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on Agpt2
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Products associated with anti-Agpt2 antibody
Pathways associated with anti-Agpt2 antibody
Diseases associated with anti-Agpt2 antibody
Organs/Tissues associated with anti-Agpt2 antibody
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