NP_954546.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
44,951 Da
NCBI Official Full Name
angiopoietin-related protein 4
NCBI Official Synonym Full Names
angiopoietin-like 4
NCBI Protein Information
angiopoietin-related protein 4
UniProt Protein Name
Angiopoietin-related protein 4
UniProt Synonym Protein Names
Angiopoietin-like protein 4; Hepatic fibrinogen/angiopoietin-related protein; HFARP
UniProt Synonym Gene Names
NCBI Summary for ANGPTL4
a circulating protein which causes an increase in plasma very low density lipoprotein by inhibition of lipoprotein lipase activity [RGD, Feb 2006]
UniProt Comments for ANGPTL4
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation ().
Research Articles on ANGPTL4
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Products associated with anti-ANGPTL4 antibody
Pathways associated with anti-ANGPTL4 antibody
Diseases associated with anti-ANGPTL4 antibody
Organs/Tissues associated with anti-ANGPTL4 antibody
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