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anti-ANK1 antibody :: Goat Ankyrin 1/ANK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421627 anti-ANK1 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ankyrin 1/ANK1, Polyclonal Antibody

 Also Known As   

Goat anti-Ankyrin 1/ANK1 Antibody

 Product Synonym Names    ANK1; ankyrin 1, erythrocytic; ANK; SPH1; SPH2; ankyrin 1; ankyrin-1, erythrocytic; ankyrin-R; ANK1 antibody; ankyrin 1; erythrocytic antibody; ANK antibody; SPH1 antibody; SPH2 antibody; ankyrin 1 antibody; ankyrin-1; erythrocytic antibody; ankyrin-R antibody; Ankyrin 1; Ankyrin 1 / ANK1
 Product Gene Name   

anti-ANK1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Ankyrin 1 / ANK1 peptide (MBS426113) is used for blocking the activity of Ankyrin 1/ANK1 antibody (MBS421627)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QIVKRASLKR GKQ
 OMIM    182900
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QIVKRASLKRGKQ, from the C Terminus of the protein sequence according to NP_000028.3; NP_065208.2; NP_065209.2; NP_065210.2; NP_065211.2; NP_065213.2.
 Epitope    C Terminus
 Note    This antibody is expected to recognise isoform 3 (NP_000028.3) and isoform 5 (NP_065211.2).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ANK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ANK1 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-ANK1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Preliminary experiments gave approx.19-23 kDa bands in Human Skeletal Muscle lysates after 0. 01ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for these bands we observe given the observed 28+30 kDa bands in the literature for this tissue (PMID: 9430667) and given the calculated size of 17. 6 kDa according to NP_065211.2. The 19-22 kDa bands were successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for ANK1. It may not necessarily be applicable to this product.
 NCBI GI #    70780357
 NCBI GeneID    286
 NCBI Accession #    NP_000028.3 [Other Products]
 NCBI Related Accession #    NP_065208.2; NP_065209.2; NP_065210.2; NP_065211.2; NP_065213.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000037.3 [Other Products]
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 UniProt Secondary Accession #    O43400; Q13768; Q53ER1; Q59FP2; Q8N604; Q99407; A0PJN8; A6NJ23; E5RFL7 [Other Products]
 UniProt Related Accession #    P16157 [Other Products]
 Molecular Weight    17,854 Da
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 NCBI Official Full Name    ankyrin-1 isoform 3
 NCBI Official Synonym Full Names    ankyrin 1
 NCBI Official Symbol    ANK1 [Similar Products]
 NCBI Official Synonym Symbols   
ANK; SPH1; SPH2
[Similar Products]
 NCBI Protein Information    ankyrin-1
 UniProt Protein Name    Ankyrin-1
 UniProt Synonym Protein Names   
Ankyrin-R; Erythrocyte ankyrin
 Protein Family    Ankyrin
 UniProt Gene Name    ANK1 [Similar Products]
 UniProt Synonym Gene Names    ANK; ANK-1 [Similar Products]
 UniProt Entry Name    ANK1_HUMAN
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 NCBI Summary for ANK1    Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
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 UniProt Comments for ANK1    ANK1: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Defects in ANK1 are a cause of spherocytosis type 1 (SPH1); also called hereditary spherocytosis type 1 (HS1). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Inheritance can be autosomal dominant or recessive. 21 isoforms of the human protein are produced by alternative promoter.

Protein type: Adaptor/scaffold; Cell development/differentiation; Endoplasmic reticulum; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p11.1

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function: ATPase binding; cytoskeletal adaptor activity; enzyme binding; protein binding; spectrin binding; structural constituent of cytoskeleton

Biological Process: ER to Golgi vesicle-mediated transport; maintenance of epithelial cell polarity

Disease: Spherocytosis, Type 1
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 Research Articles on ANK1    1. analysis of a novel p.Q1772X ANK1 mutation in a Korean family with hereditary spherocytosis [case report of two family members]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ANK1 antibodyPathways associated with anti-ANK1 antibody
 Reference Product  PubMed Publications
 SPTB antibody  >13 publications with ANK1 and SPTB
 SPTA1 antibody  >11 publications with ANK1 and SPTA1
 OBSCN antibody  >10 publications with ANK1 and OBSCN
 CD44 antibody  >3 publications with ANK1 and CD44
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CHL1 Interactions Pathway antibodies  CHL1 Interactions Pathway Diagram
 COPI-mediated Anterograde Transport Pathway antibodies  COPI-mediated Anterograde Transport Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
Diseases associated with anti-ANK1 antibodyOrgans/Tissues associated with anti-ANK1 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >40 publications with ANK1 and Anemia
 Anemia, Hemolytic Antibodies  >36 publications with ANK1 and Anemia, Hemolytic
 Nervous System Diseases Antibodies  >9 publications with ANK1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >4 publications with ANK1 and Disease Models, Animal
 Edema Antibodies  >3 publications with ANK1 and Edema
 Kidney Diseases Antibodies  >3 publications with ANK1 and Kidney Diseases
 Breast Neoplasms Antibodies  >3 publications with ANK1 and Breast Neoplasms
 Urogenital Abnormalities Antibodies  >2 publications with ANK1 and Urogenital Abnormalities
 Hypertrophy Antibodies  >2 publications with ANK1 and Hypertrophy
 Inflammation Antibodies  >2 publications with ANK1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >53 publications with ANK1 and Blood
 Muscle Antibodies  >29 publications with ANK1 and Muscle
 Brain Antibodies  >10 publications with ANK1 and Brain
 Heart Antibodies  >8 publications with ANK1 and Heart
 Embryonic Tissue Antibodies  >4 publications with ANK1 and Embryonic Tissue
 Nerve Antibodies  >3 publications with ANK1 and Nerve
 Spleen Antibodies  >3 publications with ANK1 and Spleen
 Bone Antibodies  >3 publications with ANK1 and Bone
 Pancreas Antibodies  >2 publications with ANK1 and Pancreas
 Eye Antibodies  >2 publications with ANK1 and Eye
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