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anti-ANK1 antibody :: Rabbit anti-Human Ankyrin-1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS852707
Testing Data
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ankyrin-1 (ANK1), Polyclonal Antibody

 Also Known As   

Ankyrin-1 Antibody

 Product Gene Name   

anti-ANK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    612641
 3D Structure    ModBase 3D Structure for P16157
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    anti-ANK1 antibody purified by peptide affinity column containing 1% BSA and 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal ANK1 (1) antibody was raised against a peptide from the N terminal residues of human ANK1 protein.
 Reactivity Note    Predicted: Mouse, Rat; Not yet tested in other species.
 Pathway    Ankyrin-1
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 Other Notes    Small volumes of anti-ANK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ANK1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-ANK1 antibody   

Western Blot (WB)

 Application Notes for anti-ANK1 antibody    ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Optimal dilutions/concentrations should be determined by the end use.
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 Testing Data of anti-ANK1 antibody    anti-ANK1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ANK1. It may not necessarily be applicable to this product.
 NCBI GI #    70780357
 NCBI GeneID    286
 NCBI Accession #    NP_000028.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000037.3 [Other Products]
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 UniProt Primary Accession #    P16157 [Other Products]
 UniProt Secondary Accession #    O43400; Q13768; Q53ER1; Q59FP2; Q8N604; Q99407; A0PJN8; A6NJ23; E5RFL7 [Other Products]
 UniProt Related Accession #    P16157 [Other Products]
 Molecular Weight    17,854 Da [Similar Products]
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 NCBI Official Full Name    ankyrin-1 isoform 3
 NCBI Official Synonym Full Names    ankyrin 1, erythrocytic
 NCBI Official Symbol    ANK1 [Similar Products]
 NCBI Official Synonym Symbols   
ANK; SPH1; SPH2
[Similar Products]
 NCBI Protein Information    ankyrin-1; ANK-1; ankyrin-R; erythrocyte ankyrin
 UniProt Protein Name    Ankyrin-1
 UniProt Synonym Protein Names   
Ankyrin-R; Erythrocyte ankyrin
 Protein Family    Ankyrin
 UniProt Gene Name    ANK1 [Similar Products]
 UniProt Synonym Gene Names    ANK; ANK-1 [Similar Products]
 UniProt Entry Name    ANK1_HUMAN
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 NCBI Summary for ANK1    Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
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 UniProt Comments for ANK1    ANK1: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Defects in ANK1 are a cause of spherocytosis type 1 (SPH1); also called hereditary spherocytosis type 1 (HS1). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Inheritance can be autosomal dominant or recessive. 21 isoforms of the human protein are produced by alternative promoter.

Protein type: Adaptor/scaffold; Cell development/differentiation; Endoplasmic reticulum; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p11.1

Cellular Component: cortical cytoskeleton; postsynaptic membrane; cytoskeleton; sarcoplasmic reticulum; basolateral plasma membrane; plasma membrane; M band; axolemma; nucleus; Z disc; cytosol; sarcolemma

Molecular Function: protein binding; enzyme binding; spectrin binding; structural constituent of cytoskeleton; cytoskeletal adaptor activity; structural molecule activity; ATPase binding

Biological Process: axon guidance; erythrocyte development; ER to Golgi vesicle-mediated transport; iron ion homeostasis; exocytosis; monovalent inorganic cation transport; cytoskeleton organization and biogenesis; signal transduction; porphyrin biosynthetic process; maintenance of epithelial cell polarity

Disease: Spherocytosis, Type 1
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Product References and Citations for anti-ANK1 antibody

   (1) Harder,M.N., Ribel-Madsen,R., Justesen,J.M.,. et al. Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased beta-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort. J. Clin. Endocrinol. Metab. 98 (4), E801-E806 (2013)
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 Research Articles on ANK1    1. ANK1 rs516946 confers impaired insulin release.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ANK1 antibodyPathways associated with anti-ANK1 antibody
 Reference Product  PubMed Publications
 SPTB antibody  >10 publications with ANK1 and SPTB
 OBSCN antibody  >9 publications with ANK1 and OBSCN
 SPTA1 antibody  >9 publications with ANK1 and SPTA1
 SLC4A1 antibody  >7 publications with ANK1 and SLC4A1
 CD44 antibody  >1 publications with ANK1 and CD44
 L1CAM antibody  >1 publications with ANK1 and L1CAM
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CHL1 Interactions Pathway antibodies  CHL1 Interactions Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Neurofascin Interactions Pathway antibodies  Neurofascin Interactions Pathway Diagram
 NrCAM Interactions Pathway antibodies  NrCAM Interactions Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
Diseases associated with anti-ANK1 antibodyOrgans/Tissues associated with anti-ANK1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with ANK1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >3 publications with ANK1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with ANK1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with ANK1 and Kidney Diseases
 Congenital Abnormalities Antibodies  >2 publications with ANK1 and Congenital Abnormalities
 Urogenital Abnormalities Antibodies  >2 publications with ANK1 and Urogenital Abnormalities
 Prostatic Neoplasms Antibodies  >2 publications with ANK1 and Prostatic Neoplasms
 Edema Antibodies  >2 publications with ANK1 and Edema
 Disorders of Sex Development Antibodies  >2 publications with ANK1 and Disorders of Sex Development
 Hypertrophy Antibodies  >2 publications with ANK1 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >44 publications with ANK1 and Blood
 Muscle Antibodies  >26 publications with ANK1 and Muscle
 Heart Antibodies  >8 publications with ANK1 and Heart
 Brain Antibodies  >7 publications with ANK1 and Brain
 Embryonic Tissue Antibodies  >4 publications with ANK1 and Embryonic Tissue
 Spleen Antibodies  >3 publications with ANK1 and Spleen
 Bone Antibodies  >3 publications with ANK1 and Bone
 Nerve Antibodies  >2 publications with ANK1 and Nerve
 Lymph Node Antibodies  >2 publications with ANK1 and Lymph Node
 Prostate Antibodies  >2 publications with ANK1 and Prostate
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