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anti-ANXA5 antibody :: Rabbit Annexin V Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175603
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Annexin V (ANXA5), Polyclonal Antibody

 Also Known As   

Anti-Annexin V antibody

 Product Synonym Names    Annexin A5; annexin A5; Anchorin CII antibody; Annexin 5 antibody; Annexin A5 antibody; Annexin V antibody; Annexin-5 antibody; Annexin5 antibody; AnnexinA5 antibody; AnnexinV antibody; ANX 5 antibody; ANX A5 antibody; ANX5 antibody; ANXA5 antibody; ANXA5_HUMAN antibody; Calphobindin I antibody; CBP I antibody; CBP-I antibody; Endonexin II antibody; ENX 2 antibody; ENX2 antibody; Lipocortin V antibody; PAP I antibody; PAP-I antibody; Placental anticoagulant protein 4 antibody; Placental anticoagulant protein I antibody; PLACENTAL PROTEIN 4 antibody; PP 4 antibody; PP4 antibody; Thromboplastin inhibitor antibody; VAC alpha antibody; VAC-alpha antibody; Vascular anticoagulant alpha antibody; Vascular anticoagulant-alpha antibody
 Product Gene Name   

anti-ANXA5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614391
 3D Structure    ModBase 3D Structure for P08758
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence in the middle region of human Annexin V (88-102aa SRLYDAYELKHALKG), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ANXA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ANXA5 antibody

   Description: Rabbit IgG polyclonal antibody for Annexin A5(ANXA5) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.
Background: Annexin V also know as endonnexin II(ENX2),or placental protein 4(PP4). Endonexin II is a member of the family of Ca(2+)-dependent phospholipid binding proteins, known as annexins. It bind to the phospholipids that are preferentially located on the cytosolic face of the plasma membrane. It has a relative molecular weight of about 35,000. The gene lies on mouse chromosome 3 in close linkage with the fibroblast growth factor 2(basic) gene and is syntenic with other genes known to have orthologous counterparts on human chromosome 4q. The PP4 cDNA encoded a protein of 320 amino acid residues. A single mRNA, approximately 1.6 kb long, was found to be expressed in human cell lines and placenta. PP4 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
 Applications Tested/Suitable for anti-ANXA5 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

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 Western Blot (WB) of anti-ANXA5 antibody    Anti-Annexin V antibody, Western blotting
All lanes: Anti Annexin V at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Rat Skeletal Muscle Tissue Lysate at 50ug
Lane 3: Rat Ovary Tissue Lysate at 50ug
Lane 4: Rat Lung Tissue Lysate at 50ug
Lane 5: MCF-7 Whole Cell Lysate at 40ug
Lane 6: SMMC Whole Cell Lysate at 40ug
Lane 7: A549 Whole Cell Lysate at 40ug
Lane 8: JURKAT Whole Cell Lysate at 40ug
Lane 9: SGC Whole Cell Lysate at 40ug
Lane 10: HT1080 Whole Cell Lysate at 40ug
Predicted bind size: 36KD
Observed bind size: 36KD
anti-ANXA5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ANXA5 antibody    Anti-Annexin V antibody, IHC(P)
IHC(P): Rat Liver Tissue
anti-ANXA5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunocytochemistry (ICC) of anti-ANXA5 antibody    Anti-Annexin V antibody, ICC
ICC: HCT116 Cell
anti-ANXA5 antibody Immunocytochemistry (ICC) (ICC) image
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 Immunocytochemistry (ICC) of anti-ANXA5 antibody    Anti-Annexin V antibody, ICC
ICC: HELA Cell
anti-ANXA5 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for ANXA5. It may not necessarily be applicable to this product.
 NCBI GI #    113960
 NCBI GeneID    308
 NCBI Accession #    P08758.2 [Other Products]
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 UniProt Primary Accession #    P08758 [Other Products]
 UniProt Secondary Accession #    Q6FHB3; Q6FI16; Q8WV69; Q9UDH9; D3DNW7 [Other Products]
 UniProt Related Accession #    P08758 [Other Products]
 Molecular Weight    35,937 Da
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 NCBI Official Full Name    Annexin A5
 NCBI Official Synonym Full Names    annexin A5
 NCBI Official Symbol    ANXA5 [Similar Products]
 NCBI Official Synonym Symbols   
PP4; ANX5; ENX2; RPRGL3; HEL-S-7
[Similar Products]
 NCBI Protein Information    annexin A5; CBP-I; PAP-I; VAC-alpha; annexin V; annexin-5; anchorin CII; endonexin II; lipocortin V; calphobindin I; thromboplastin inhibitor; vascular anticoagulant-alpha; epididymis secretory protein Li 7; placental anticoagulant protein 4; placental anticoagulant protein I
 UniProt Protein Name    Annexin A5
 UniProt Synonym Protein Names   
Anchorin CII; Annexin V; Annexin-5; Calphobindin I; CBP-I; Endonexin II; Lipocortin V; Placental anticoagulant protein 4; PP4; Placental anticoagulant protein I; PAP-I; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha
 Protein Family    Annexin
 UniProt Gene Name    ANXA5 [Similar Products]
 UniProt Synonym Gene Names    ANX5; ENX2; PP4; CBP-I; PP4; PAP-I; VAC-alpha [Similar Products]
 UniProt Entry Name    ANXA5_HUMAN
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 NCBI Summary for ANXA5    The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ANXA5    ANXA5: a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Lipid-binding; Apoptosis; Inhibitor

Chromosomal Location of Human Ortholog: 4q27

Cellular Component: focal adhesion; membrane; cytoplasm; intracellular; external side of plasma membrane

Molecular Function: phospholipase inhibitor activity; calcium-dependent phospholipid binding; phospholipid binding; calcium ion binding

Biological Process: response to organic substance; negative regulation of catalytic activity; blood coagulation; signal transduction; negative regulation of coagulation; negative regulation of apoptosis

Disease: Pregnancy Loss, Recurrent, Susceptibility To, 3
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 Research Articles on ANXA5    1. The annexin 5 in serums of pregnant women and patients with particular types of cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ANXA5 antibodyPathways associated with anti-ANXA5 antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >625 publications with ANXA5 and CASP3
 S100B antibody  >3 publications with ANXA5 and S100B
 VIM antibody  >2 publications with ANXA5 and VIM
 PKD1 antibody  >1 publications with ANXA5 and PKD1
 PRL antibody  >1 publications with ANXA5 and PRL
 Products by Pathway  Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
Diseases associated with anti-ANXA5 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >530 publications with ANXA5 and Necrosis
 Cardiovascular Diseases Antibodies  >387 publications with ANXA5 and Cardiovascular Diseases
 Inflammation Antibodies  >245 publications with ANXA5 and Inflammation
 Heart Diseases Antibodies  >143 publications with ANXA5 and Heart Diseases
 Disease Models, Animal Antibodies  >143 publications with ANXA5 and Disease Models, Animal
 Lung Diseases Antibodies  >100 publications with ANXA5 and Lung Diseases
 Breast Neoplasms Antibodies  >99 publications with ANXA5 and Breast Neoplasms
 Liver Diseases Antibodies  >99 publications with ANXA5 and Liver Diseases
 Liver Neoplasms Antibodies  >74 publications with ANXA5 and Liver Neoplasms
 Lung Neoplasms Antibodies  >68 publications with ANXA5 and Lung Neoplasms
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