P08133.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,423 Da
NCBI Official Full Name
Annexin A6
NCBI Official Synonym Full Names
annexin A6
NCBI Official Synonym Symbols
NCBI Protein Information
annexin A6; p68; p70; CPB-II; annexin-6; calelectrin; lipocortin VI; calphobindin II; calphobindin-II; chromobindin-20; annexin VI (p68); 67 kDa calelectrin; calcium-binding protein p68
UniProt Protein Name
Annexin A6
UniProt Synonym Protein Names
67 kDa calelectrin; Annexin VI; Annexin-6; Calphobindin-II; CPB-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70
UniProt Synonym Gene Names
UniProt Entry Name
ANXA6_HUMAN
NCBI Summary for ANXA6
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
UniProt Comments for ANXA6
ANXA6: a calcium/phospholipid-binding protein that may associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Phosphorylated in response to growth factor stimulation. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
Protein type: Lipid-binding; Calcium-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: focal adhesion; membrane; lysosomal membrane; perinuclear region of cytoplasm; late endosome membrane; melanosome
Molecular Function: protein binding; protein homodimerization activity; GTP binding; calcium-dependent phospholipid binding; cholesterol binding; calcium ion binding; calcium-dependent protein binding; lipid binding; ligand-gated ion channel activity
Biological Process: regulation of muscle contraction; calcium ion transport; protein homooligomerization
Research Articles on ANXA6
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Products associated with anti-ANXA6 antibody
Pathways associated with anti-ANXA6 antibody
Diseases associated with anti-ANXA6 antibody
Organs/Tissues associated with anti-ANXA6 antibody
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