NP_060623.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,742 Da
NCBI Official Full Name
anthrax toxin receptor 1 isoform 3
NCBI Official Synonym Full Names
anthrax toxin receptor 1
NCBI Protein Information
anthrax toxin receptor 1
UniProt Protein Name
Anthrax toxin receptor 1
UniProt Synonym Protein Names
Tumor endothelial marker 8
UniProt Synonym Gene Names
UniProt Entry Name
ANTR1_HUMAN
NCBI Summary for ANTXR1
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
UniProt Comments for ANTXR1
ANTXR1: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI). HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. Belongs to the ATR family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, integral; Actin-binding
Chromosomal Location of Human Ortholog: 2p13.1
Cellular Component: cell surface; endosome membrane; filopodium membrane; integral to membrane; plasma membrane
Molecular Function: actin filament binding; collagen binding; metal ion binding; protein binding; transmembrane receptor activity
Biological Process: actin cytoskeleton reorganization; reproductive process; signal transduction
Disease: Gapo Syndrome; Hemangioma, Capillary Infantile
Research Articles on ANTXR1
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Products associated with anti-ANTXR1 antibody
Pathways associated with anti-ANTXR1 antibody
Diseases associated with anti-ANTXR1 antibody
Organs/Tissues associated with anti-ANTXR1 antibody
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