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anti-SERPINF2 antibody :: Goat anti-Human Antiplasmin, alpha2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS610398 anti-SERPINF2 antibody
Unit / Price
0.2 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Antiplasmin, alpha2 (SERPINF2), Polyclonal Antibody

 Also Known As   

Antiplasmin, alpha2 (HRP)

 Product Synonym Names    Anti -Antiplasmin, alpha2 (HRP)
 Product Gene Name   

anti-SERPINF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (1646130..1658559). Location: 17p13
 OMIM    262850
 3D Structure    ModBase 3D Structure for P08697
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Human
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 Specificity    Recognizes human Antiplasmin, alpha2. Assay by Immunoelectrophoresis has one arc with normal plasma.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in a buffered stabilizer solution, 50% glycerol. No preservatives added. Labeled with HRP.
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 Immunogen    Human alpha2 Antiplasmin (alpha2AP) purified from plasma
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Labeled with horseradish peroxidase (HRP). Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. HRP conjugates are sensitive to light.
 Other Notes    Small volumes of anti-SERPINF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SERPINF2 antibody

   Alpha 2Antiplasmin (alpha,2AP), also known as alpha 2Plasmin Inhibitor (alpha 2PI), is a member of the SERPIN family of proteinase inhibitors and the primary inhibitor of the enzyme plasmin in blood. It is produced in the liver and circulates in plasma at ~70ug/ml (~1uM). alpha 2AP is a single chain molecule with a mass of 67kD as determined by SDS-PAGE. The primary target enzyme for alpha 2AP is plasmin, but alpha 2AP also acts as secondary or "backup" inhibitor of activated F.XI, activated Protein C and trypsin. Inhibition of these enzymes by alpha 2AP occurs by proteolytic cleavage after Arg364 with subsequent rapid formation of a stable, inactive 1:1 enzyme-alpha 2AP complex. alpha 2AP also acts to regulate fibrinolysis by binding to the lysine binding sites on plasminogen thus competitively inhibiting plasminogen binding to fibrin. About 30% of alpha 2AP present in plasma is partially degraded and lacks a peptide in the carboxyl region that contains the plasminogen-binding site. This form of alpha 2AP (~65kD) has a reduced rate of plasmin inhibition and has been referred to as the "slow form" of alpha 2AP. During fibrin formation, a portion of circulating alpha 2AP is cross-linked to the alpha -chain of fibrin by activated factor XIII, and this linking of plasmin inhibitor to the plasmin substrate provides an additional measure of protection to the fibrin clot from proteolysis by plasmin.
 Product Categories/Family for anti-SERPINF2 antibody    Antibodies; Abs to Coagulation Factors
 Applications Tested/Suitable for anti-SERPINF2 antibody   

ELISA (EL/EIA)

 Application Notes for anti-SERPINF2 antibody    Suitable for use in Immunoelectrophoresis and ELISA.
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NCBI/Uniprot data below describe general gene information for SERPINF2. It may not necessarily be applicable to this product.
 NCBI GI #    115583663
 NCBI GeneID    5345
 NCBI Accession #    NP_000925.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000934.3 [Other Products]
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 UniProt Primary Accession #    P08697 [Other Products]
 UniProt Secondary Accession #    Q8N5U7; Q9UCG2; Q9UCG3 [Other Products]
 UniProt Related Accession #    P08697 [Other Products]
 Molecular Weight    54,566 Da [Similar Products]
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 NCBI Official Full Name    alpha-2-antiplasmin isoform a
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
 NCBI Official Symbol    SERPINF2 [Similar Products]
 NCBI Official Synonym Symbols   
AAP; API; PLI; A2AP; ALPHA-2-PI
[Similar Products]
 NCBI Protein Information    alpha-2-antiplasmin; serpin F2; alpha-2-AP; OTTHUMP00000115656; OTTHUMP00000197008; OTTHUMP00000197009; alpha-2-plasmin inhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
 UniProt Protein Name    Alpha-2-antiplasmin
 UniProt Synonym Protein Names   
Alpha-2-plasmin inhibitor; Alpha-2-PI; Serpin F2
 Protein Family    Alpha-2-antiplasmin
 UniProt Gene Name    SERPINF2 [Similar Products]
 UniProt Synonym Gene Names    AAP; PLI [Similar Products]
 UniProt Entry Name    A2AP_HUMAN
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 NCBI Summary for SERPINF2    This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for SERPINF2    SERPINF2: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID). APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis. Belongs to the serpin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protein homodimerization activity; protease binding; endopeptidase inhibitor activity

Biological Process: platelet activation; collagen fibril organization; positive regulation of smooth muscle cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; response to organic substance; fibrinolysis; platelet degranulation; negative regulation of fibrinolysis; renin-angiotensin regulation of blood vessel size; positive regulation of stress fiber formation; acute-phase response; blood vessel morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; blood coagulation

Disease: Alpha-2-plasmin Inhibitor Deficiency
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 Research Articles on SERPINF2    1. ADAMTS13 inactivation by plasmin as a potential cause of thrombotic thrombocytopenic purpura
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SERPINF2 antibodyPathways associated with anti-SERPINF2 antibody
 Reference Product  PubMed Publications
 F11 antibody  >1 publications with SERPINF2 and F11
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation Pathway antibodies  Platelet Activation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
Diseases associated with anti-SERPINF2 antibodyOrgans/Tissues associated with anti-SERPINF2 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with SERPINF2 and Liver Diseases
 Thrombosis Antibodies  >1 publications with SERPINF2 and Thrombosis
 Venous Thrombosis Antibodies  >1 publications with SERPINF2 and Venous Thrombosis
 Adenocarcinoma Antibodies  >1 publications with SERPINF2 and Adenocarcinoma
 Neoplasms Antibodies  >1 publications with SERPINF2 and Neoplasms
 Inflammation Antibodies  >1 publications with SERPINF2 and Inflammation
 Hepatitis Antibodies  >1 publications with SERPINF2 and Hepatitis
 Liver Neoplasms Antibodies  >1 publications with SERPINF2 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with SERPINF2 and Carcinoma, Hepatocellular
 Adenoma Antibodies  >1 publications with SERPINF2 and Adenoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with SERPINF2 and Blood
 Liver Antibodies  >2 publications with SERPINF2 and Liver
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