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anti-Apg7 antibody :: Rabbit anti-Human Apg7 / ATG7 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240615
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apg7 / ATG7, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human Apg7 / ATG7

 Product Synonym Names    Anti-Apg7 / ATG7 Antibody (aa558-569) IHC-plus; ATG7; Apg7; APG7L; APG7-LIKE; Autophagy related 7; Autophagy-related protein 7; HAGP7; GSA7; Human Apg7; ATG7
 Product Gene Name   

anti-Apg7 antibody

[Similar Products]
 Product Synonym Gene Name    ATG7 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608760
 3D Structure    ModBase 3D Structure for O95352
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    aa 558-569 of Human Apg7 protein.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human ATG7.
 Immunogen Type    Synthetic peptide
 Immunogen    Apg7 / ATG7 antibody was raised against synthetic peptide from human ATG7.
 Antigen Modification    aa558-569
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-Apg7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-Apg7 antibody   

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-Apg7 antibody    ELISA (1:15000 - 1:75000), IF, IHC-P (10 ug/ml), WB (1:500 - 1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-Apg7 antibody    Anti-ATG7 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-Apg7 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for Apg7. It may not necessarily be applicable to this product.
 NCBI GI #    5453668
 NCBI GeneID    10533
 NCBI Accession #    NP_006386.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006395.2 [Other Products]
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 UniProt Primary Accession #    O95352 [Other Products]
 UniProt Secondary Accession #    Q7L8L0; Q9BWP2; Q9UFH4; B4E170; E9PB95 [Other Products]
 UniProt Related Accession #    O95352 [Other Products]
 Molecular Weight    68,618 Da
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 NCBI Official Full Name    ubiquitin-like modifier-activating enzyme ATG7 isoform a
 NCBI Official Synonym Full Names    autophagy related 7
 NCBI Official Symbol    ATG7 [Similar Products]
 NCBI Official Synonym Symbols   
GSA7; APG7L; APG7-LIKE
[Similar Products]
 NCBI Protein Information    ubiquitin-like modifier-activating enzyme ATG7; hAGP7; autophagy-related protein 7; ATG12-activating enzyme E1 ATG7; ATG7 autophagy related 7 homolog; ubiquitin activating enzyme E1-like protein; ubiquitin-activating enzyme E1-like protein
 UniProt Protein Name    Ubiquitin-like modifier-activating enzyme ATG7
 UniProt Synonym Protein Names   
ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; APG7-like; hAGP7; Ubiquitin-activating enzyme E1-like protein
 UniProt Gene Name    ATG7 [Similar Products]
 UniProt Synonym Gene Names    APG7L; APG7-like; hAGP7 [Similar Products]
 UniProt Entry Name    ATG7_HUMAN
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 NCBI Summary for Apg7    This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq, Jan 2009]
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 UniProt Comments for Apg7    ATG7: Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3. Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. Belongs to the ATG7 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: cytoplasm; axoneme; cytosol

Molecular Function: protein binding; protein homodimerization activity; APG8 activating enzyme activity; APG12 activating enzyme activity; ubiquitin activating enzyme activity; transcription factor binding

Biological Process: positive regulation of apoptosis; regulation of protein ubiquitination; protein ubiquitination; pyramidal neuron development; adult walking behavior; post-embryonic development; protein transport; cardiac muscle cell development; protein amino acid lipidation; protein catabolic process; positive regulation of autophagy; amino acid metabolic process; central nervous system neuron axonogenesis; cerebellar Purkinje cell layer development; protein modification process; C-terminal protein lipidation; liver development; cellular response to starvation; neurological system process; cellular response to nitrogen starvation; protein modification by small protein conjugation; mitochondrion degradation; positive regulation of protein modification process; positive regulation of protein catabolic process; cerebral cortex development; positive regulation of macroautophagy; negative regulation of apoptosis
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 Research Articles on Apg7    1. the Atg7.caspase-9 complex performs a dual function of linking caspase-9 to the autophagic process while keeping in check its apoptotic activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Apg7 antibodyPathways associated with anti-Apg7 antibody
 Reference Product  PubMed Publications
 ATG5 antibody  >247 publications with Apg7 and ATG5
 ATG12 antibody  >86 publications with Apg7 and ATG12
 ATG3 antibody  >68 publications with Apg7 and ATG3
 ATG10 antibody  >20 publications with Apg7 and ATG10
 MAP1LC3B antibody  >18 publications with Apg7 and MAP1LC3B
 MAP1LC3A antibody  >12 publications with Apg7 and MAP1LC3A
 GABARAPL2 antibody  >8 publications with Apg7 and GABARAPL2
 GABARAPL1 antibody  >7 publications with Apg7 and GABARAPL1
 SIRT1 antibody  >5 publications with Apg7 and SIRT1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
Diseases associated with anti-Apg7 antibodyOrgans/Tissues associated with anti-Apg7 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >53 publications with Apg7 and Necrosis
 Nervous System Diseases Antibodies  >52 publications with Apg7 and Nervous System Diseases
 Inflammation Antibodies  >41 publications with Apg7 and Inflammation
 Liver Diseases Antibodies  >36 publications with Apg7 and Liver Diseases
 Cardiovascular Diseases Antibodies  >26 publications with Apg7 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >23 publications with Apg7 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >20 publications with Apg7 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >15 publications with Apg7 and Liver Neoplasms
 Heart Diseases Antibodies  >12 publications with Apg7 and Heart Diseases
 Lung Neoplasms Antibodies  >11 publications with Apg7 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >78 publications with Apg7 and Brain
 Muscle Antibodies  >70 publications with Apg7 and Muscle
 Liver Antibodies  >68 publications with Apg7 and Liver
 Blood Antibodies  >59 publications with Apg7 and Blood
 Heart Antibodies  >40 publications with Apg7 and Heart
 Lung Antibodies  >37 publications with Apg7 and Lung
 Kidney Antibodies  >21 publications with Apg7 and Kidney
 Bone Antibodies  >17 publications with Apg7 and Bone
 Intestine Antibodies  >16 publications with Apg7 and Intestine
 Skin Antibodies  >14 publications with Apg7 and Skin
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