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anti-APOB antibody :: Rabbit anti-Human, Mouse Apolipoprotein B48/100 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS611063 anti-APOB antibody
Unit / Price
1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein B48/100 (APOB), Polyclonal Antibody

 Also Known As   

Apolipoprotein B48/100 (Apo B48/100)

 Product Synonym Names    Anti -Apolipoprotein B48/100 (Apo B48/100)
 Product Gene Name   

anti-APOB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (21224301..21266945, complement). Location: 2p24-p23
 OMIM    107730
 3D Structure    ModBase 3D Structure for P04114
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes mouse Apo B48 (241kD) and B100 (513kD) as these proteins are highly conserved. Species Crossreactivity: human
 Purity/Purification    Serum
Heat inactivated serum
 Form/Format    Supplied as a liquid, 0.05% sodium azide.
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 Immunogen    Mouse low density lipoprotein (LDL)
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-APOB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-APOB antibody

   Apolipoprotein B plays an essential role in lipid transport and metabolism. Apo B may regulate cholesterol synthesis through its interaction with specific cell membrane receptors and by inhibition of HMG CoA reductase. This enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Apo B may be important in the genesis of atherosclerosis. Apo B is the major protein moiety of all lipoproteins other than high density lipoprotein (HDL) in plasma. Increased levels of apo B100 are associated with an increased risk of coronary artery disease. Apo B exists in human plasma as two isoforms: apo B48 and apo B100. Apo B100 is the major physiological ligand for the LDL receptor. It contains 4536aa residues. Apo B100 is the full length protein. Its gene has been mapped on the short arm of chromosome 2, with an ~length of 43kb and 29 exons. Apo B100 is synthesised in the liver. It is required for the assembly of very low density lipoproteins (VLDL). It does not interchange between lipoprotein particles, as do the other lipoproteins. It is found in IDL and LDL particles after the removal of the apolipoproteins A, E and C. Apo B48 is present in chylomicrons and chylomicron remnants. It plays an essential role in the intestinal absorption of dietary fats. Apo B48 is synthesized in the small intestine. It comprises the N-terminal 48% of apo B100. Apo B48 is the degraded protein. Apo B48 lacks the LDL receptor-binding domain of Apo B100. It is produced due to post-transscriptional Apo B100 mRNA editing at codon 2153, which creates a stop codon in the intestine instead of a glutamine in the liver.
 Product Categories/Family for anti-APOB antibody    Antibodies; Abs to Lipoproteins
 Applications Tested/Suitable for anti-APOB antibody   

Western Blot (WB)

 Application Notes for anti-APOB antibody    Suitable for use in Radial Immunodiffusion (RID) and Western Blot.
Titer: RID End-Point Titer: 1:15
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NCBI/Uniprot data below describe general gene information for APOB. It may not necessarily be applicable to this product.
 NCBI GI #    105990532
 NCBI GeneID    338
 NCBI Accession #    NP_000375.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000384.2 [Other Products]
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 UniProt Primary Accession #    P04114 [Other Products]
 UniProt Secondary Accession #    O00502; P78479; P78480; P78481; Q13779; Q13785; Q13786; Q13787; Q13788; Q4ZG63; Q53QC8 [Other Products]
 UniProt Related Accession #    P04114; P78482; Q13789; Q13828; Q59HB3; Q7Z7Q0; Q9UE51; Q9UE52; Q9UE53 [Other Products]
 Molecular Weight    515,605 Da [Similar Products]
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 NCBI Official Full Name    apolipoprotein B-100
 NCBI Official Synonym Full Names    apolipoprotein B (including Ag(x) antigen)
 NCBI Official Symbol    APOB [Similar Products]
 NCBI Official Synonym Symbols   
FLDB; LDLCQ4
[Similar Products]
 NCBI Protein Information    apolipoprotein B-100; apoB-48; apoB-100; apo B-100; mutant Apo B 100; OTTHUMP00000115994; apolipoprotein B48
 UniProt Protein Name    Apolipoprotein B-100
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOB [Similar Products]
 UniProt Entry Name    APOB_HUMAN
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 NCBI Summary for APOB    This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq]
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 UniProt Comments for APOB    APOB: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Defects in APOB are a cause of familial hypobetalipoproteinemia type 1 (FHBL1). A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.

Protein type: Secreted, signal peptide; Carrier; Secreted

Chromosomal Location of Human Ortholog: 2p24-p23

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum membrane; intracellular membrane-bound organelle; endoplasmic reticulum lumen; early endosome; extracellular region; cytosol; actin cytoskeleton; chylomicron; cell soma; cytoplasm; plasma membrane; endosome membrane

Molecular Function: heparin binding; protein binding; low-density lipoprotein receptor binding; cholesterol transporter activity; phospholipid binding

Biological Process: lipoprotein catabolic process; phototransduction, visible light; response to lipopolysaccharide; response to carbohydrate stimulus; post-embryonic development; response to selenium ion; triacylglycerol catabolic process; retinoid metabolic process; transmembrane transport; cholesterol metabolic process; nervous system development; receptor-mediated endocytosis; cholesterol transport; in utero embryonic development; regulation of cholesterol biosynthetic process; response to virus; cholesterol efflux; lipoprotein metabolic process; sperm motility; cholesterol homeostasis; fertilization; lipoprotein transport; lipoprotein biosynthetic process; artery morphogenesis; spermatogenesis; triacylglycerol mobilization; blood coagulation; leukocyte migration

Disease: Hypercholesterolemia, Autosomal Dominant, Type B; Hypobetalipoproteinemia, Familial, 1
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 Research Articles on APOB    1. Provide evidence that a common genome-wide significant single-nucleotide polymorphism, rs7575840, may affect serum apoB, LDL cholesterol, and total cholesterol levels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APOB antibodyPathways associated with anti-APOB antibody
 Reference Product  PubMed Publications
 APOA1 antibody  >325 publications with APOB and APOA1
 LDLR antibody  >287 publications with APOB and LDLR
 LIPC antibody  >23 publications with APOB and LIPC
 MTTP antibody  >22 publications with APOB and MTTP
 BGN antibody  >8 publications with APOB and BGN
 HSPA8 antibody  >1 publications with APOB and HSPA8
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 LDL-mediated Lipid Transport Pathway antibodies  LDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
Diseases associated with anti-APOB antibodyOrgans/Tissues associated with anti-APOB antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2877 publications with APOB and Cardiovascular Diseases
 Hyperlipidemias Antibodies  >2188 publications with APOB and Hyperlipidemias
 Atherosclerosis Antibodies  >2177 publications with APOB and Atherosclerosis
 Coronary Disease Antibodies  >1632 publications with APOB and Coronary Disease
 Myocardial Ischemia Antibodies  >1503 publications with APOB and Myocardial Ischemia
 Arteriosclerosis Antibodies  >1372 publications with APOB and Arteriosclerosis
 Hypercholesterolemia Antibodies  >1264 publications with APOB and Hypercholesterolemia
 Hyperlipoproteinemia Type II Antibodies  >639 publications with APOB and Hyperlipoproteinemia Type II
 Obesity Antibodies  >558 publications with APOB and Obesity
 Hypertriglyceridemia Antibodies  >554 publications with APOB and Hypertriglyceridemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7088 publications with APOB and Blood
 Liver Antibodies  >1957 publications with APOB and Liver
 Heart Antibodies  >1198 publications with APOB and Heart
 Intestine Antibodies  >533 publications with APOB and Intestine
 Kidney Antibodies  >354 publications with APOB and Kidney
 Muscle Antibodies  >269 publications with APOB and Muscle
 Brain Antibodies  >115 publications with APOB and Brain
 Lung Antibodies  >102 publications with APOB and Lung
 Embryonic Tissue Antibodies  >52 publications with APOB and Embryonic Tissue
 Spleen Antibodies  >48 publications with APOB and Spleen
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