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anti-APOC3 antibody :: Rabbit anti-Human Apolipoprotein C-III Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1489974
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein C-III (APOC3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Apolipoprotein C-III polyclonal Antibody, Biotin conjugated

 Product Synonym Names    Apolipoprotein C3 APOC3
 Product Gene Name   

anti-APOC3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107720
 3D Structure    ModBase 3D Structure for P02656
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Biotin
 Immunogen    Recombinant human Apolipoprotein C-III protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23604 / sc-50377
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-APOC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-APOC3 antibody   

ELISA (EIA)

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 Western Blot (WB) of anti-APOC3 antibody    western blot All lanes: Apolipoprotein C-III antibody at 2ug/ml+rat liver tissue Secondary Goat polyclonal to Rabbit lgG at 1/15000 dilution Predicted band size:11kda Observed band size:11kda
anti-APOC3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for APOC3. It may not necessarily be applicable to this product.
 NCBI GI #    4557323
 NCBI GeneID    345
 NCBI Accession #    NP_000031.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000040.1 [Other Products]
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 UniProt Primary Accession #    P02656 [Other Products]
 UniProt Secondary Accession #    Q08E83; Q6Q786 [Other Products]
 UniProt Related Accession #    P02656 [Other Products]
 Molecular Weight    10,852 Da [Similar Products]
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 NCBI Official Full Name    apolipoprotein C-III
 NCBI Official Synonym Full Names    apolipoprotein C-III
 NCBI Official Symbol    APOC3 [Similar Products]
 NCBI Official Synonym Symbols   
HALP2; APOCIII
[Similar Products]
 NCBI Protein Information    apolipoprotein C-III
 UniProt Protein Name    Apolipoprotein C-III
 UniProt Synonym Protein Names   
Apolipoprotein C3
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOC3 [Similar Products]
 UniProt Synonym Gene Names    Apo-CIII; ApoC-III [Similar Products]
 UniProt Entry Name    APOC3_HUMAN
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 NCBI Summary for APOC3    Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for APOC3    APOC3: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2). HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Belongs to the apolipoprotein C3 family.

Protein type: Secreted, signal peptide; Secreted; Lipid-binding

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: chylomicron; early endosome; extracellular region; extracellular space

Molecular Function: cholesterol binding; enzyme regulator activity; lipase inhibitor activity; phospholipid binding

Biological Process: cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; fat-soluble vitamin metabolic process; G-protein coupled receptor protein signaling pathway; inflammatory response; lipoprotein metabolic process; lipoprotein transport; negative regulation of fatty acid biosynthetic process; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; phospholipid efflux; phototransduction, visible light; regulation of Cdc42 protein signal transduction; response to peptide hormone stimulus; response to triglyceride; response to vitamin A; retinoid metabolic process; reverse cholesterol transport; triacylglycerol catabolic process; triacylglycerol metabolic process; triacylglycerol mobilization; vitamin metabolic process

Disease: Apolipoprotein C-iii Deficiency
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 Research Articles on APOC3    1. In examined Kyrgyz ethnic population the most frequent was heterozygous TC genotype of T455C polymorphism of apo C-III.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APOC3 antibodyPathways associated with anti-APOC3 antibody
 Reference Product  PubMed Publications
 APOE antibody  >82 publications with APOC3 and APOE
 APOA5 antibody  >80 publications with APOC3 and APOA5
 APOA1 antibody  >80 publications with APOC3 and APOA1
 APOB antibody  >62 publications with APOC3 and APOB
 LPL antibody  >56 publications with APOC3 and LPL
 APOA4 antibody  >49 publications with APOC3 and APOA4
 APOA2 antibody  >16 publications with APOC3 and APOA2
 LDLR antibody  >13 publications with APOC3 and LDLR
 INS antibody  >3 publications with APOC3 and INS
 PPARA antibody  >2 publications with APOC3 and PPARA
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with anti-APOC3 antibodyOrgans/Tissues associated with anti-APOC3 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >99 publications with APOC3 and Cardiovascular Diseases
 Coronary Disease Antibodies  >69 publications with APOC3 and Coronary Disease
 Heart Diseases Antibodies  >61 publications with APOC3 and Heart Diseases
 Hypertriglyceridemia Antibodies  >54 publications with APOC3 and Hypertriglyceridemia
 Dyslipidemias Antibodies  >52 publications with APOC3 and Dyslipidemias
 Atherosclerosis Antibodies  >51 publications with APOC3 and Atherosclerosis
 Insulin Resistance Antibodies  >43 publications with APOC3 and Insulin Resistance
 Hyperlipidemias Antibodies  >41 publications with APOC3 and Hyperlipidemias
 Fatty Liver Antibodies  >37 publications with APOC3 and Fatty Liver
 Hyperinsulinism Antibodies  >32 publications with APOC3 and Hyperinsulinism
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >67 publications with APOC3 and Liver
 Heart Antibodies  >54 publications with APOC3 and Heart
 Connective Tissue Antibodies  >11 publications with APOC3 and Connective Tissue
 Kidney Antibodies  >7 publications with APOC3 and Kidney
 Muscle Antibodies  >5 publications with APOC3 and Muscle
 Brain Antibodies  >3 publications with APOC3 and Brain
 Lung Antibodies  >3 publications with APOC3 and Lung
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