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anti-APOE antibody :: anti-Mouse Apolipoprotein E (Apo E) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS315478 anti-APOE antibody
Unit / Price
1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein E (Apo E) (APOE), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit A' Mouse Apo E

 Product Synonym Names    Rabbit Antibody to Mouse Apolipoprotein E (Apo E)
 Product Gene Name   

anti-APOE antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (45409039..45412650). Location: 19q13.2
 OMIM    104310
 3D Structure    ModBase 3D Structure for P02649
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 Clonality    Polyclonal
 Host    New Zealand Rabbits
 Species Reactivity    Mouse
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 Specificity    Apolipoprotein E (Apo E)
Species specific: extremely low recognition of human Apo E. No data available regarding rat activity.
 Purity/Purification    Not applicable. Heat inactivated
Product is 0.22um filtered.
 Form/Format    Neat, Liquid
 Concentration    Not determined
Titer: 1:40 (RID) (lot specific)
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 Immunogen    Purified Mouse Apolipoprotein E from pooled mouse plasma high and very low density lipoproteins
 Buffer    Not applicable
 Preservative    0.05% Sodium azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Upon receipt, aliquot and store (up to 1 year) at -70 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-APOE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-APOE antibody    Polyclonal Antibodies to Lipoproteins
 Applications Tested/Suitable for anti-APOE antibody   

DD, IEP, RID, Western Blot

 Application Notes for anti-APOE antibody    Suitable for use in Radial immunodiffusion, immuno double-diffusion, rocket IEP and Western Blot. Starting dilution for Western Blot: 1:500-1:1,000. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
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NCBI/Uniprot data below describe general gene information for APOE. It may not necessarily be applicable to this product.
 NCBI GI #    114039
 NCBI GeneID    348
 NCBI Accession #    P02649.1 [Other Products]
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 UniProt Primary Accession #    P02649 [Other Products]
 UniProt Secondary Accession #    Q9P2S4; B2RC15; C0JYY5 [Other Products]
 UniProt Related Accession #    P02649; Q13791; Q6LA97; Q6LBZ1; Q8TCZ8 [Other Products]
 Molecular Weight    36,154 Da [Similar Products]
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 NCBI Official Full Name    Apolipoprotein E
 NCBI Official Synonym Full Names    apolipoprotein E
 NCBI Official Symbol    APOE [Similar Products]
 NCBI Official Synonym Symbols   
AD2; LPG; LDLCQ5; MGC1571
[Similar Products]
 NCBI Protein Information    apolipoprotein E; apo-E; apolipoprotein E3; OTTHUMP00000159143; OTTHUMP00000197075; OTTHUMP00000197076; OTTHUMP00000197077
 UniProt Protein Name    Apolipoprotein E
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOE [Similar Products]
 UniProt Entry Name    APOE_HUMAN
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 NCBI Summary for APOE    Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq]
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 UniProt Comments for APOE    Function: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.

Subcellular location: Secreted.

Tissue specificity: Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle. Ref.18

Post-translational modification: Synthesized with the sialic acid attached by O-glycosidic linkage and is subsequently desialylated in plasma. O-glycosylated with core 1 or possibly core 8 glycans. Thr-307 is a minor glycosylation site compared to Ser-308. Ref.19Glycated in plasma VLDL of normal subjects, and of hyperglycemic diabetic patients at a higher level (2-3 fold).Phosphorylation sites are present in the extracelllular medium.

Polymorphism: Three common APOE alleles have been identified: APOE*2, APOE*3, and APOE*4. The corresponding three major isoforms, E2, E3, and E4, are recognized according to their relative position after isoelectric focusing. Different mutations causing the same migration pattern after isoelectric focusing define different isoform subtypes. The most common isoform is E3 and is present in 40-90% of the population. Common APOE variants influence lipoprotein metabolism in healthy individuals.

Involvement in disease: Defects in APOE are a cause of hyperlipoproteinemia type 3 (HLPP3) [

MIM:107741]; also known as familial dysbetalipoproteinemia. Individuals with HLPP3 are clinically characterized by xanthomas, yellowish lipid deposits in the palmar crease, or less specific on tendons and on elbows. The disorder rarely manifests before the third decade in men. In women, it is usually expressed only after the menopause. The vast majority of the patients are homozygous for APOE*2 alleles. More severe cases of HLPP3 have also been observed in individuals heterozygous for rare APOE variants. The influence of APOE on lipid levels is often suggested to have major implications for the risk of coronary artery disease (CAD). Individuals carrying the common APOE*4 variant are at higher risk of CAD. Ref.16 Ref.26 Ref.27 Ref.29Genetic variations in APOE are associated with Alzheimer disease type 2 (AD2) [

MIM:104310]. It is a late-onset neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. Note=The APOE*4 allele is genetically associated with the common late onset familial and sporadic forms of Alzheimer disease. Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE*4 alleles in 42 families with late onset AD. Thus APOE*4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE*4 was virtually sufficient to cause AD by age 80. The mechanism by which APOE*4 participates in pathogenesis is not known. Ref.16Defects in APOE are a cause of sea-blue histiocyte disease (SBHD) [

MIM:269600]; also known as sea-blue histiocytosis. This disorder is characterized by splenomegaly, mild thrombocytopenia and, in the bone marrow, numerous histiocytes containing cytoplasmic granules which stain bright blue with the usual hematologic stains. The syndrome is the consequence of an inherited metabolic defect analogous to Gaucher disease and other sphingolipidoses. Ref.16 Ref.33 Ref.36Defects in APOE are a cause of lipoprotein glomerulopathy (LPG) [

MIM:611771]. LPG is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries. It mainly affects people of Japanese and Chinese origin. The disorder has rarely been described in Caucasians. Ref.16 Ref.30 Ref.32 Ref.37

Sequence similarities: Belongs to the apolipoprotein A1/A4/E family.
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Product References and Citations for anti-APOE antibody

   • Thorngate, F.E., et al., (2000), "Low Levels of Extrahepatic Nonmacrophage ApoE Inhibit Atherosclerosis Without Correcting Hypercholesterolemia in ApoE-Deficient Mice", Arterioscler Thromb. Vasc. Biol., 20: 1939-1945
• Wang, W.J.,
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 Research Articles on APOE    1. Investigate if apolipoprotein epsilon4 allele moderates the influence of earthquake exposure on survivor health. Findings suggest a genetic variation in the apolipoprotein E gene may modify the health effects of the stress from natural disaster exposure.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APOE antibodyPathways associated with anti-APOE antibody
 Reference Product  PubMed Publications
 APP antibody  >388 publications with APOE and APP
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Statin Pathway antibodies  Statin Pathway Diagram
Diseases associated with anti-APOE antibodyOrgans/Tissues associated with anti-APOE antibody
 Disease Name  Pubmed Publications
 Central Nervous System Diseases Antibodies  >5371 publications with APOE and Central Nervous System Diseases
 Cardiovascular Diseases Antibodies  >4508 publications with APOE and Cardiovascular Diseases
 Neurodegenerative Diseases Antibodies  >4412 publications with APOE and Neurodegenerative Diseases
 Alzheimer Disease Antibodies  >4331 publications with APOE and Alzheimer Disease
 Vascular Diseases Antibodies  >4246 publications with APOE and Vascular Diseases
 Atherosclerosis Antibodies  >3402 publications with APOE and Atherosclerosis
 Arteriosclerosis Antibodies  >2934 publications with APOE and Arteriosclerosis
 Hyperlipidemias Antibodies  >1592 publications with APOE and Hyperlipidemias
 Inflammation Antibodies  >888 publications with APOE and Inflammation
 Hypercholesterolemia Antibodies  >883 publications with APOE and Hypercholesterolemia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3126 publications with APOE and Brain
 Vascular Antibodies  >2856 publications with APOE and Vascular
 Liver Antibodies  >1487 publications with APOE and Liver
 Heart Antibodies  >1081 publications with APOE and Heart
 Muscle Antibodies  >843 publications with APOE and Muscle
 Nerve Antibodies  >493 publications with APOE and Nerve
 Bone Antibodies  >377 publications with APOE and Bone
 Kidney Antibodies  >368 publications with APOE and Kidney
 Lung Antibodies  >190 publications with APOE and Lung
 Intestine Antibodies  >152 publications with APOE and Intestine
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