Q9BZZ5.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Apoptosis inhibitor 5
NCBI Official Synonym Full Names
apoptosis inhibitor 5
NCBI Protein Information
apoptosis inhibitor 5; FIF; antiapoptosis clone 11 protein; migration-inducing protein MIG8; cell migration-inducing gene 8 protein; fibroblast growth factor 2-interacting factor 2
UniProt Protein Name
Apoptosis inhibitor 5
UniProt Synonym Protein Names
Antiapoptosis clone 11 protein; AAC-11; Cell migration-inducing gene 8 protein; Fibroblast growth factor 2-interacting factor; FIF; Protein XAGL
UniProt Synonym Gene Names
UniProt Entry Name
API5_HUMAN
NCBI Summary for API5
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
UniProt Comments for API5
API5: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Belongs to the API5 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; Apoptosis
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: nucleoplasm; spliceosome; membrane; cytoplasm; nucleus
Molecular Function: protein binding; fibroblast growth factor binding
Biological Process: apoptosis; negative regulation of apoptosis
Research Articles on API5
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Products associated with anti-API5 antibody
Diseases associated with anti-API5 antibody
Organs/Tissues associated with anti-API5 antibody
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