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anti-NOL3 antibody :: Rabbit Apoptosis repressor with CARD Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175694
Western Blot (WB)
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apoptosis repressor with CARD (NOL3), Polyclonal Antibody

 Also Known As   

Anti-Apoptosis repressor with CARD antibody

 Product Synonym Names    Nucleolar protein 3; nucleolar protein 3(apoptosis repressor with CARD doma); Apoptosis repressor with CARD antibody; ARC antibody; Muscle enriched cytoplasmic protein antibody; Muscle-enriched cytoplasmic protein antibody; MYC antibody; MYP antibody; Nol3 antibody; NOL3_HUMAN antibody; NOP antibody; Nop30 antibody; Nucleolar protein 3(apoptosis repressor with CARD domain) antibody; Nucleolar protein 3 antibody; Nucleolar protein of 30 kDa antibody
 Product Gene Name   

anti-NOL3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614937
 3D Structure    ModBase 3D Structure for O60936
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence in the middle region of human Apoptosis repressor with CARD (91-106aa WDWQHVGPGYRDRSYD), identical to the related rat sequence, and different from the related mouse sequence by one amino acid.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NOL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NOL3 antibody

   Description: Rabbit IgG polyclonal antibody for Nucleolar protein 3(NOL3) detection. Tested with WB in Human, Mouse, Rat.
Background: NOL3(Nucleolar protein 3), also known as ARC, NOP30, CARD2 and MYP, is a protein that in humans is encoded by the NOL3 gene. NOL3 has been shown to interact with SFRS9 and Caspase 8. By genomic sequence analysis, Stoss et al.(1999) determined that the NOL3 gene, which encodes NOP30 and MYP and which they called NOP, is composed of 4 exons. The alternative 5-prime splice site that generates the 2 isoforms is located in exon 2. It is reported that expression of the ARC cDNA encoding the smaller transcript inhibited apoptosis in a dose-dependent manner when coexpressed with CASP8 but not when coexpressed with CASP9. ARC also inhibited apoptosis induced by stimulation of CD95/FAS, tumor necrosis factor receptor-1, and TRAMP/death receptor-3. Enzymatic analysis showed that ARC inhibits the enzymatic activity of CASP8. Immunoprecipitation and immunoblot analysis indicated that ARC interacts with CASP2 and CASP8 through its N-terminal death effector domain but does not interact with CASP1, CASP3, or CASP9.
 Applications Tested/Suitable for anti-NOL3 antibody   

Western Blot (WB)

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 Western Blot (WB) of anti-NOL3 antibody    Anti-Apoptosis repressor with CARD antibody, MBS175694, Western blotting
Lane 1: SMMC Cell Lysate
Lane 2: A549 Cell Lysate
Lane 3: U87 Cell Lysate
Lane 4: HELA Cell Lysate
Lane 5: MCF-7 Cell Lysate
Lane 6: Rat Liver Tissue Lysate

anti-NOL3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NOL3. It may not necessarily be applicable to this product.
 NCBI GI #    20455079
 NCBI GeneID    8996
 NCBI Accession #    O60936.1 [Other Products]
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 UniProt Primary Accession #    O60936 [Other Products]
 UniProt Secondary Accession #    O60937; B4DFL0 [Other Products]
 UniProt Related Accession #    O60936 [Other Products]
 Molecular Weight    29,355 Da
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 NCBI Official Full Name    Nucleolar protein 3
 NCBI Official Synonym Full Names    nucleolar protein 3 (apoptosis repressor with CARD domain)
 NCBI Official Symbol    NOL3 [Similar Products]
 NCBI Official Synonym Symbols   
ARC; FCM; MYP; NOP; NOP30
[Similar Products]
 NCBI Protein Information    nucleolar protein 3; nucleolar protein of 30 kDa; muscle-enriched cytoplasmic protein
 UniProt Protein Name    Nucleolar protein 3
 UniProt Synonym Protein Names   
Apoptosis repressor with CARD; Muscle-enriched cytoplasmic protein; Myp; Nucleolar protein of 30 kDa; Nop30
 Protein Family    Nucleolar protein
 UniProt Gene Name    NOL3 [Similar Products]
 UniProt Synonym Gene Names    ARC; NOP; Myp; Nop30 [Similar Products]
 UniProt Entry Name    NOL3_HUMAN
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 NCBI Summary for NOL3    This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
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 UniProt Comments for NOL3    Isoform 1: May be involved in RNA splicing.
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 Research Articles on NOL3    1. high expression of ARC plays an important role in the pathogenesis of nasopharyngeal carcinoma and leads to X-radiation and cisplatin resistance in nasopharyngeal carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NOL3 antibodyDiseases associated with anti-NOL3 antibody
 Reference Product  PubMed Publications
 CASP8 antibody  >18 publications with NOL3 and CASP8
 BAX antibody  >8 publications with NOL3 and BAX
 FADD antibody  >6 publications with NOL3 and FADD
 TP53 antibody  >1 publications with NOL3 and TP53
 BCL2L1 antibody  >1 publications with NOL3 and BCL2L1
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >17 publications with NOL3 and Cardiovascular Diseases
 Heart Diseases Antibodies  >14 publications with NOL3 and Heart Diseases
 Nervous System Diseases Antibodies  >11 publications with NOL3 and Nervous System Diseases
 Necrosis Antibodies  >10 publications with NOL3 and Necrosis
 Brain Diseases Antibodies  >7 publications with NOL3 and Brain Diseases
 Disease Models, Animal Antibodies  >7 publications with NOL3 and Disease Models, Animal
 Cardiomyopathies Antibodies  >6 publications with NOL3 and Cardiomyopathies
 Breast Neoplasms Antibodies  >4 publications with NOL3 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with NOL3 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with NOL3 and Liver Neoplasms
Organs/Tissues associated with anti-NOL3 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >78 publications with NOL3 and Muscle
 Brain Antibodies  >26 publications with NOL3 and Brain
 Nerve Antibodies  >6 publications with NOL3 and Nerve
 Liver Antibodies  >4 publications with NOL3 and Liver
 Embryonic Tissue Antibodies  >3 publications with NOL3 and Embryonic Tissue
 Kidney Antibodies  >2 publications with NOL3 and Kidney
 Bone Antibodies  >1 publications with NOL3 and Bone
 Intestine Antibodies  >1 publications with NOL3 and Intestine
 Thyroid Antibodies  >1 publications with NOL3 and Thyroid
 Stomach Antibodies  >1 publications with NOL3 and Stomach
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