CAG46821.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
AQP2, partial
NCBI Official Synonym Full Names
aquaporin 2
NCBI Protein Information
aquaporin-2
UniProt Protein Name
Aquaporin-2
UniProt Synonym Protein Names
ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
UniProt Synonym Gene Names
UniProt Entry Name
AQP2_RAT
NCBI Summary for AQP2
This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]
UniProt Comments for AQP2
AQP2: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family.
Protein type: Channel, misc.; Transporter, aquaporin family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Cellular Component: apical plasma membrane; basolateral plasma membrane; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; early endosome; integral to plasma membrane; lysosome; membrane; plasma membrane; pore complex; protein complex; recycling endosome; rough endoplasmic reticulum; trans-Golgi network; transport vesicle
Molecular Function: actin binding; glycerol channel activity; glycerol transmembrane transporter activity; PDZ domain binding; porin activity; protein binding; water channel activity; water transporter activity
Biological Process: actin filament depolymerization; aging; apoptosis; cell volume homeostasis; cellular response to water deprivation; cellular water homeostasis; female pregnancy; glycerol transport; hyperosmotic response; positive regulation of calcium ion transport; renal water transport; response to calcium ion; response to glucagon stimulus; response to hormone stimulus; response to lipopolysaccharide; response to lithium ion; response to salt stress; response to starvation; response to water deprivation; transmembrane transport; water homeostasis; water transport
Research Articles on AQP2
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Products associated with anti-AQP2 antibody
Pathways associated with anti-AQP2 antibody
Diseases associated with anti-AQP2 antibody
Organs/Tissues associated with anti-AQP2 antibody
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