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anti-AQP2 antibody :: Rabbit Aquaporin 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540992 anti-AQP2 antibody
Unit / Price
0.1 mg FITC  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aquaporin 2 (AQP2), Polyclonal Antibody

 Also Known As   

Aquaporin 2 Antibody FITC-Conjugated

 Product Synonym Names    ADH water channel; AQP 2; AQP CD; Aquaporin 2 collecting duct; Aquaporin CD; Collecting duct water channel protein; MGC34501; Water channel aquaporin 2; Water channel protein for renal collecting duct; WCH CD antibody
 Product Gene Name   

anti-AQP2 antibody

[Similar Products]
 Antibody/Peptide Pairs    Aquaporin 2 peptide (MBS542370) is used for blocking the activity of Aquaporin 2 antibody (MBS540992)
 Matching Pairs    Antibody: Aquaporin 2 (MBS540992)
Positive Control: Aquaporin 2 (MBS542535)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P34080
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Bovine, Human, Mouse, Rat, Sheep
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 Form/Format    FITC-Conjugated
 Concentration    0.50-0.62 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 200-250 on human Aquaporin 2 protein.
 Immunoglobulin    IgG
 Expression    Renal collecting tubules
 Molecular Function    Transport
 Structure    Contain two tandem repeats each with three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala
 Subcellular Location    Apical cell membrane; Multiplass membrane protein; Basolateral cell membrane
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-AQP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-AQP2 antibody

   Forms a water-specific channel that provies the plasma mebranes of red cells and kidney proximal tubules with water permeability.
 Applications Tested/Suitable for anti-AQP2 antibody   

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-AQP2 antibody    ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for AQP2. It may not necessarily be applicable to this product.
 NCBI GI #    49457001
 NCBI GeneID    359
 NCBI Accession #    CAG46821.1 [Other Products]
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 UniProt Primary Accession #    P34080 [Other Products]
 UniProt Secondary Accession #    A1A5L4 [Other Products]
 UniProt Related Accession #    P41181 [Other Products]
 Molecular Weight    28,931 Da [Similar Products]
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 NCBI Official Full Name    AQP2, partial
 NCBI Official Synonym Full Names    aquaporin 2
 NCBI Official Symbol    AQP2 [Similar Products]
 NCBI Official Synonym Symbols   
AQP-CD; WCH-CD
[Similar Products]
 NCBI Protein Information    aquaporin-2
 UniProt Protein Name    Aquaporin-2
 UniProt Synonym Protein Names   
ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
 UniProt Gene Name    Aqp2 [Similar Products]
 UniProt Synonym Gene Names    AQP-2; AQP-CD [Similar Products]
 UniProt Entry Name    AQP2_RAT
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 NCBI Summary for AQP2    This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]
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 UniProt Comments for AQP2    AQP2: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Protein type: Transporter, aquaporin family; Membrane protein, multi-pass; Transporter; Channel, misc.; Membrane protein, integral

Cellular Component: apical plasma membrane; basolateral plasma membrane; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; early endosome; integral to plasma membrane; lysosome; membrane; plasma membrane; pore complex; protein complex; recycling endosome; rough endoplasmic reticulum; trans-Golgi network; transport vesicle

Molecular Function: actin binding; glycerol channel activity; glycerol transmembrane transporter activity; PDZ domain binding; porin activity; protein binding; water channel activity; water transporter activity

Biological Process: actin filament depolymerization; aging; apoptosis; cell volume homeostasis; cellular response to water deprivation; cellular water homeostasis; female pregnancy; glycerol transport; hyperosmotic response; positive regulation of calcium ion transport; renal water transport; response to calcium ion; response to glucagon stimulus; response to hormone stimulus; response to lipopolysaccharide; response to lithium ion; response to salt stress; response to starvation; response to water deprivation; transmembrane transport; water homeostasis; water transport
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 Research Articles on AQP2    1. Partial congenital nephrogenic diabetes insipidus in the Swedish family is caused by an AQP2 variation that seems to disable the encoded AQP2-R254W protein to reach the subapical vesicle population as well as impairing its phosphorylation at S256
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AQP2 antibodyPathways associated with anti-AQP2 antibody
 Reference Product  PubMed Publications
 Aqp3 antibody  >238 publications with AQP2 and Aqp3
 Slc12a1 antibody  >52 publications with AQP2 and Slc12a1
 Agt antibody  >2 publications with AQP2 and Agt
 Rapgef3 antibody  >1 publications with AQP2 and Rapgef3
 Prkaca antibody  >1 publications with AQP2 and Prkaca
 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Passive Transport By Aquaporins Pathway antibodies  Passive Transport By Aquaporins Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway antibodies  Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
Diseases associated with anti-AQP2 antibodyOrgans/Tissues associated with anti-AQP2 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >362 publications with AQP2 and Kidney Diseases
 Diabetes Insipidus, Nephrogenic Antibodies  >274 publications with AQP2 and Diabetes Insipidus, Nephrogenic
 Polyuria Antibodies  >151 publications with AQP2 and Polyuria
 Disease Models, Animal Antibodies  >103 publications with AQP2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >88 publications with AQP2 and Cardiovascular Diseases
 Hypertension Antibodies  >67 publications with AQP2 and Hypertension
 Heart Failure Antibodies  >66 publications with AQP2 and Heart Failure
 Heart Diseases Antibodies  >58 publications with AQP2 and Heart Diseases
 Brain Diseases Antibodies  >38 publications with AQP2 and Brain Diseases
 Edema Antibodies  >38 publications with AQP2 and Edema
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >970 publications with AQP2 and Kidney
 Prostate Antibodies  >4 publications with AQP2 and Prostate
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