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anti-AQP4 antibody :: Rabbit anti-Mouse Aquaporin 4 (AQP4) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004472 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $170 +1 FREE 8GB USB
0.1 mg  /  $210 +1 FREE 8GB USB
0.2 mg  /  $315 +1 FREE 8GB USB
1 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aquaporin 4 (AQP4), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Aquaporin 4 (AQP4)

 Product Gene Name   

anti-AQP4 antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Aquaporin 4 (AQP4) (MBS2004472)
Biotin Conjugated Antibody: Aquaporin 4 (AQP4) (MBS2003039)
 Matching Pairs    Antibody: Aquaporin 4 (AQP4) (MBS2004472)
Antigen: Aquaporin 4 (AQP4) (MBS2011163)
 Matching Pairs    Unconjugated Antibody: Aquaporin 4 (AQP4) (MBS2004472)
APC-CY7 Conjugated Antibody: Aquaporin 4 (AQP4) (MBS2044512)
 Matching Pairs    Unconjugated Antibody: Aquaporin 4 (AQP4) (MBS2004472)
PE Conjugated Antibody: Aquaporin 4 (AQP4) (MBS2044513)
 Matching Pairs    Unconjugated Antibody: Aquaporin 4 (AQP4) (MBS2004472)
APC-CY7 Conjugated Antibody: Aquaporin 4 (AQP4) (MBS2044514)
 Matching Pairs    Unconjugated Antibody: Aquaporin 4 (AQP4) (MBS2004472)
Cy3 Conjugated Antibody: Aquaporin 4 (AQP4) (MBS2044515)
 Matching Pairs    Unconjugated Antibody: Aquaporin 4 (AQP4) (MBS2004472)
FITC Conjugated Antibody: Aquaporin 4 (AQP4) (MBS2044516)
 Matching Pairs    Unconjugated Antibody: Aquaporin 4 (AQP4) (MBS2004472)
HRP Conjugated Antibody: Aquaporin 4 (AQP4) (MBS2044517)
 Matching Pairs    Unconjugated Antibody: Aquaporin 4 (AQP4) (MBS2004472)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Aquaporin 4 (AQP4) (MBS2004472)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-SCDS KRTDVTGSIA LAIGFSVAIG HLFAINYTGA SMNPARSFGP AVIMGNWANH WIYWVGPIMG AVLAGALYEY VFCPDVELKR RLKEAFSKAA QQTKGSYMEV EDNRSQVETE DLILKPGVVH VIDI
 3D Structure    ModBase 3D Structure for P55088
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    The antibody is a rabbit polyclonal antibody raised against AQP4. It has been selected for its ability to recognize AQP4 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 UOM    100ug
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2044514
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-AQP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-AQP4 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-AQP4 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-AQP4 antibody    (Figure. Western Blot; Sample: Mouse Heart Tissue.)
anti-AQP4 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-AQP4 antibody    (Figure. Western Blot; Sample: Recombinant AQP4, Mouse.)
anti-AQP4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-AQP4 antibody    (DAB staining on IHC-P; Samples: Mouse Cerebrum Tissue)
anti-AQP4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-AQP4 antibody    (Figure. DAB staining on IHC-P; Samples: Mouse Brain Tissue.)
anti-AQP4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for AQP4. It may not necessarily be applicable to this product.
 NCBI GI #    821324787
 NCBI GeneID    11829
 NCBI Accession #    NP_001295570.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001308641.1 [Other Products]
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 UniProt Primary Accession #    P55088 [Other Products]
 UniProt Secondary Accession #    P97818; Q4FJP1; Q61131; Q61132; Q8VHE4; Q8VHE5; Q9EQI3 [Other Products]
 UniProt Related Accession #    P55088 [Other Products]
 Molecular Weight    37,977 Da
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 NCBI Official Full Name    aquaporin-4 isoform M23
 NCBI Official Synonym Full Names    aquaporin 4
 NCBI Official Symbol    Aqp4 [Similar Products]
 NCBI Official Synonym Symbols   
WCH4
[Similar Products]
 NCBI Protein Information    aquaporin-4
 UniProt Protein Name    Aquaporin-4
 UniProt Synonym Protein Names   
Mercurial-insensitive water channel; MIWC; WCH4
 Protein Family    Aquaporin
 UniProt Gene Name    Aqp4 [Similar Products]
 UniProt Synonym Gene Names    AQP-4; MIWC [Similar Products]
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 NCBI Summary for AQP4    This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
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 UniProt Comments for AQP4    AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described

Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 18 A1|18 8.74 cM

Cellular Component: basal plasma membrane; basolateral plasma membrane; cell projection membrane; cytoplasm; external side of plasma membrane; integral component of membrane; integral component of plasma membrane; intercellular junction; membrane; plasma membrane; protein complex; sarcolemma; T-tubule

Molecular Function: identical protein binding; porin activity; protein binding; transporter activity; water channel activity

Biological Process: carbon dioxide transport; cellular response to glucose stimulus; cellular response to interferon-gamma; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; protein homooligomerization; regulation of vascular endothelial growth factor production; renal water absorption; sensory perception of sound; transport; water homeostasis; water transport
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 Research Articles on AQP4    1. In anhedonic mice, the expression of the water channel aquaporin 4 (AQP4), a factor in glymphatic pathway dysfunction, was down-regulated in cortex and hippocampus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AQP4 antibodyPathways associated with anti-AQP4 antibody
 Reference Product  PubMed Publications
 Aqp2 antibody  >157 publications with AQP4 and Aqp2
 Kcnj10 antibody  >48 publications with AQP4 and Kcnj10
 Trpv4 antibody  >4 publications with AQP4 and Trpv4
 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Passive Transport By Aquaporins Pathway antibodies  Passive Transport By Aquaporins Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway antibodies  Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
Diseases associated with anti-AQP4 antibodyOrgans/Tissues associated with anti-AQP4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1242 publications with AQP4 and Nervous System Diseases
 Neuromyelitis Optica Antibodies  >804 publications with AQP4 and Neuromyelitis Optica
 Brain Diseases Antibodies  >631 publications with AQP4 and Brain Diseases
 Edema Antibodies  >559 publications with AQP4 and Edema
 Disease Models, Animal Antibodies  >276 publications with AQP4 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >227 publications with AQP4 and Cardiovascular Diseases
 Inflammation Antibodies  >168 publications with AQP4 and Inflammation
 Necrosis Antibodies  >60 publications with AQP4 and Necrosis
 Kidney Diseases Antibodies  >45 publications with AQP4 and Kidney Diseases
 Hypertension Antibodies  >39 publications with AQP4 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1223 publications with AQP4 and Brain
 Spinal Cord Antibodies  >369 publications with AQP4 and Spinal Cord
 Kidney Antibodies  >178 publications with AQP4 and Kidney
 Eye Antibodies  >161 publications with AQP4 and Eye
 Muscle Antibodies  >128 publications with AQP4 and Muscle
 Lung Antibodies  >73 publications with AQP4 and Lung
 Heart Antibodies  >45 publications with AQP4 and Heart
 Intestine Antibodies  >33 publications with AQP4 and Intestine
 Embryonic Tissue Antibodies  >28 publications with AQP4 and Embryonic Tissue
 Thymus Antibodies  >7 publications with AQP4 and Thymus
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