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anti-ARR3 antibody :: Chicken anti-Human Arrestin 3, Retinal Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS615907 anti-ARR3 antibody
Unit / Price
0.05 mg  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Arrestin 3, Retinal (ARR3), Polyclonal Antibody

 Also Known As   

Arrestin 3, Retinal (ARR3, X-Arrestin)

 Product Synonym Names    Anti -Arrestin 3, Retinal (ARR3, X-Arrestin)
 Product Gene Name   

anti-ARR3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (69488185..69501690). Location: Xcen-q21
 OMIM    301770
 3D Structure    ModBase 3D Structure for P36575
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 Clonality    Polyclonal
 Isotype    IgY
 Host    Chicken
 Species Reactivity    Human
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 Specificity    Recognizes human ARR3.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2. No preservative added. Glycerol free.
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 Immunogen    Synthetic peptide corresponding to aa290-389
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-ARR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ARR3 antibody

   Beta-arrestin 1 is a member of the arrestin family, which has been implicated in mediating the desensitization and internalization of G protein-coupled receptors (GPCR). Beta-arrestin 1 is constitutively phosphorylated by Erk1/2 at serine 412 of the C-terminus and localized in the cytosol. When recruited to the plasma membrane after agonist stimulation of the beta2-adrenergic receptors, beta-arrestin 1 is rapidly dephosphorylated. This dephosphorylation is an essential step of beta-arrestin 1-mediated receptor endocytosis, but it is not required for receptor desensitization.
 Product Categories/Family for anti-ARR3 antibody    Antibodies; Abs to Arrestin
 Applications Tested/Suitable for anti-ARR3 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-ARR3 antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:2000
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NCBI/Uniprot data below describe general gene information for ARR3. It may not necessarily be applicable to this product.
 NCBI GI #    119625755
 NCBI GeneID    407
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 UniProt Primary Accession #    P36575 [Other Products]
 UniProt Secondary Accession #    Q5JT23; Q5JT24; Q6IBF5; Q96EN2; B5B0B9 [Other Products]
 UniProt Related Accession #    P36575 [Other Products]
 Molecular Weight    42,778 Da [Similar Products]
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 NCBI Official Full Name    arrestin 3, retinal (X-arrestin), isoform CRA_c
 NCBI Official Synonym Full Names    arrestin 3, retinal (X-arrestin)
 NCBI Official Symbol    ARR3 [Similar Products]
 NCBI Official Synonym Symbols   
ARRX
[Similar Products]
 NCBI Protein Information    arrestin-C; cArr; C-arrestin; X-arrestin; arrestin 4; cone arrestin; OTTHUMP00000023466; OTTHUMP00000023467; retinal cone arrestin-3
 UniProt Protein Name    Arrestin-C
 UniProt Synonym Protein Names   
Cone arrestin; C-arrestin; cArr; Retinal cone arrestin-3; X-arrestin
 Protein Family    Arrestin
 UniProt Gene Name    ARR3 [Similar Products]
 UniProt Synonym Gene Names    ARRX; CAR [Similar Products]
 UniProt Entry Name    ARRC_HUMAN
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 UniProt Comments for ARR3    ARR3: May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins. Belongs to the arrestin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xcen-q21

Cellular Component: photoreceptor outer segment; photoreceptor inner segment; cytoplasm; synapse

Molecular Function: protein binding; opsin binding; phosphoprotein binding

Biological Process: regulation of protein amino acid phosphorylation; visual perception; endocytosis; signal transduction
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 Research Articles on ARR3    1. upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2)R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ARR3 antibodyPathways associated with anti-ARR3 antibody
 Reference Product  PubMed Publications
 ADRB2 antibody  >3 publications with ARR3 and ADRB2
 Products by Pathway  Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Thromboxane A2 Receptor Signaling Pathway antibodies  Thromboxane A2 Receptor Signaling Pathway Diagram
 Visual Signal Transduction: Cones Pathway antibodies  Visual Signal Transduction: Cones Pathway Diagram
Diseases associated with anti-ARR3 antibodyOrgans/Tissues associated with anti-ARR3 antibody
 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >1 publications with ARR3 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >5 publications with ARR3 and Eye
 Muscle Antibodies  >1 publications with ARR3 and Muscle
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