EAW90421.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,392 Da
NCBI Official Full Name
arrestin, beta 2, isoform CRA_c
NCBI Official Synonym Full Names
arrestin beta 2
NCBI Protein Information
beta-arrestin-2
UniProt Protein Name
Beta-arrestin-2
UniProt Synonym Protein Names
Arrestin beta-2
UniProt Synonym Gene Names
NCBI Summary for ARRb2
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for ARRb2
ARRB2: a member of the arrestin/beta-arrestin protein family. These proteins participate in agonist-mediated desensitization of G-protein-coupled receptors. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Expressed at high levels in the CNS and peripheral blood leukocytes.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; endocytic vesicle; nucleus; plasma membrane
Molecular Function: angiotensin receptor binding; enzyme binding; G-protein-coupled receptor binding; protein binding; protein complex scaffold; receptor binding; ubiquitin protein ligase binding
Biological Process: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; G-protein coupled receptor internalization; inhibition of NF-kappaB transcription factor; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of protein ubiquitination; platelet activation; positive regulation of protein ubiquitination; positive regulation of receptor internalization; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; receptor internalization; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on ARRb2
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Products associated with anti-ARRb2 antibody
Pathways associated with anti-ARRb2 antibody
Diseases associated with anti-ARRb2 antibody
Organs/Tissues associated with anti-ARRb2 antibody
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