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anti-ARRB2 antibody :: Goat Arrestin beta 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420529
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Arrestin beta 2 (ARRB2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Arrestin beta 2 Antibody

 Product Synonym Names    ARRB2; arrestin, beta 2; HGNC: 712; ARB2; ARR2; DKFZp686L0365; arrestin beta 2; beta-arrestin 2; BARR2; arrestin 3; arrestin; beta 2 antibody; ARRB2 antibody; HGNC: 712 antibody; ARB2 antibody; ARR2 antibody; DKFZp686L0365 antibody; arrestin beta 2 antibody; beta-arrestin 2 antibody; BARR2 antibody; Arrestin beta 2; Arrestin beta 2
 Product Gene Name   

anti-ARRB2 antibody

[Similar Products]
 Antibody/Peptide Pairs    Arrestin beta 2 peptide (MBS426091) is used for blocking the activity of Arrestin beta 2 antibody (MBS420529)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    HDHIPLPRPQ S
 OMIM    107941
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-HDHIPLPRPQS, from the internal region of the protein sequence according to NP_004304.1; NP_945355.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise both reported isoforms NP_004304.1 and NP_945355.1. No crossreactivity is expected with Arrestin beta 1.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ARRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ARRB2 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-ARRB2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Cerebellum shows mainly nuclear staining of purkinje cells and neuronal cells in the Molecular Layer. Recommended concentration, 4-6ug/ml.
Western Blot: Approx 40kDa band observed in Human Brain lysates (calculated MW of 46.1kDa according to NP_004304.1 and 44.4 according to NP_945355.1). Recommended concentration: 0.3-1ug/ml. An anonymous customer found positive results in WB on Rat aortic smooth muscle. An anonymous customer found positive results in WB on Mouse smooth muscle. An anonymous customer found positive results in WB on Mouse aortic smooth muscle. An anonymous customer found positive results in WB on Human colon adenocarcinoma cells (SW480).
Immunoprecipitation: This antibody has been successfully used in IP from rat leukocytes as described in the following paper: Zakrzewicz et al, Immunobiology.2011 Jul;216(7): 854-61; PMID: 21193245.
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 Western Blot (WB) of anti-ARRB2 antibody    (0.3ug/ml) staining of Human Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ARRB2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ARRB2 antibody    (4ug/ml) staining of paraffin embedded Human Cerebellum. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
anti-ARRB2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ARRB2. It may not necessarily be applicable to this product.
 NCBI GI #    4757780
 NCBI GeneID    409
 NCBI Accession #    NP_004304.1 [Other Products]
 NCBI Related Accession #    NP_945355.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004313.3 [Other Products]
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 UniProt Secondary Accession #    Q0Z8D3; Q2PP19; Q6ICT3; Q8N7Y2; Q9UEQ6; B4DLW0; B5B0C0; B7WPL3; D3DTK2; H0Y688 [Other Products]
 UniProt Related Accession #    P32121 [Other Products]
 Molecular Weight    44,392 Da
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 NCBI Official Full Name    beta-arrestin-2 isoform 1
 NCBI Official Synonym Full Names    arrestin beta 2
 NCBI Official Symbol    ARRB2 [Similar Products]
 NCBI Official Synonym Symbols   
ARB2; ARR2; BARR2
[Similar Products]
 NCBI Protein Information    beta-arrestin-2
 UniProt Protein Name    Beta-arrestin-2
 UniProt Synonym Protein Names   
Arrestin beta-2
 Protein Family    Beta-arrestin
 UniProt Gene Name    ARRB2 [Similar Products]
 UniProt Synonym Gene Names    ARB2; ARR2 [Similar Products]
 UniProt Entry Name    ARRB2_HUMAN
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 NCBI Summary for ARRB2    Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
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 UniProt Comments for ARRB2    ARRB2: a member of the arrestin/beta-arrestin protein family. These proteins participate in agonist-mediated desensitization of G-protein-coupled receptors. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Expressed at high levels in the CNS and peripheral blood leukocytes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: basolateral plasma membrane; coated pit; cytoplasm; cytoplasmic vesicle; cytosol; dendritic spine; endocytic vesicle; nucleus; plasma membrane; postsynaptic density; postsynaptic membrane

Molecular Function: alpha-1A adrenergic receptor binding; alpha-1B adrenergic receptor binding; angiotensin receptor binding; D1 dopamine receptor binding; enzyme binding; follicle stimulating hormone receptor binding; G-protein-coupled receptor binding; mitogen-activated protein kinase binding; platelet activating factor receptor binding; protein binding; protein complex binding; protein complex scaffold; protein domain specific binding; protein kinase B binding; receptor binding; type 1 angiotensin receptor binding; type 2A serotonin receptor binding; ubiquitin protein ligase binding

Biological Process: adult walking behavior; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; brain development; detection of temperature stimulus involved in sensory perception of pain; dopamine receptor signaling pathway; follicle-stimulating hormone signaling pathway; G-protein coupled receptor internalization; inhibition of NF-kappaB transcription factor; negative regulation of caspase activity; negative regulation of interleukin-1 beta production; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of protein kinase B signaling cascade; negative regulation of protein ubiquitination; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; platelet activation; positive regulation of calcium ion transport; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of protein ubiquitination; positive regulation of receptor internalization; positive regulation of synaptic transmission, dopaminergic; proteasomal ubiquitin-dependent protein catabolic process; protein transport; protein ubiquitination; receptor internalization; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
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 Research Articles on ARRB2    1. interaction of beta-arrestin with GPCRs, and the beta-arrestin conformational changes in real time and in living human cells, using a series of fluorescence resonance energy transfer (FRET)-based beta-arrestin2 biosensors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ARRB2 antibodyDiseases associated with anti-ARRB2 antibody
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Activation Of SMO Pathway antibodies  Activation Of SMO Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Atypical NF-kappaB Pathway antibodies  Atypical NF-kappaB Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Beta-catenin Independent WNT Signaling Pathway antibodies  Beta-catenin Independent WNT Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with ARRB2 and Inflammation
 Liver Diseases Antibodies  >4 publications with ARRB2 and Liver Diseases
 Poisoning Antibodies  >3 publications with ARRB2 and Poisoning
 Movement Disorders Antibodies  >3 publications with ARRB2 and Movement Disorders
 Amphetamine-Related Disorders Antibodies  >3 publications with ARRB2 and Amphetamine-Related Disorders
 Liver Neoplasms, Experimental Antibodies  >2 publications with ARRB2 and Liver Neoplasms, Experimental
 Liver Neoplasms Antibodies  >2 publications with ARRB2 and Liver Neoplasms
 Drug-Related Side Effects and Adverse Reactions Antibodies  >2 publications with ARRB2 and Drug-Related Side Effects and Adverse Reactions
 Necrosis Antibodies  >2 publications with ARRB2 and Necrosis
 Fibrosis Antibodies  >1 publications with ARRB2 and Fibrosis
Organs/Tissues associated with anti-ARRB2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with ARRB2 and Brain
 Blood Antibodies  >7 publications with ARRB2 and Blood
 Liver Antibodies  >6 publications with ARRB2 and Liver
 Bone Antibodies  >5 publications with ARRB2 and Bone
 Kidney Antibodies  >4 publications with ARRB2 and Kidney
 Lung Antibodies  >4 publications with ARRB2 and Lung
 Vascular Antibodies  >3 publications with ARRB2 and Vascular
 Pancreas Antibodies  >2 publications with ARRB2 and Pancreas
 Eye Antibodies  >2 publications with ARRB2 and Eye
 Bone Marrow Antibodies  >2 publications with ARRB2 and Bone Marrow
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