P41738.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,332 Da
NCBI Official Full Name
Aryl hydrocarbon receptor
NCBI Official Synonym Full Names
aryl hydrocarbon receptor
NCBI Protein Information
aryl hydrocarbon receptor
UniProt Protein Name
Aryl hydrocarbon receptor
UniProt Synonym Gene Names
NCBI Summary for AhR
binds 3-methylcholanthrene and other aromatic hydrocarbons; may play a role in bone formation [RGD, Feb 2006]
UniProt Comments for AhR
AHR: a nuclear receptor for aryl hydrocarbons involved in xenobiotic metabolism, cell cycle regulation, and development in response to both endogenous and environmental signals. AhR was initially identified as a receptor for dioxins, which are environmental pollutants generated by waste incineration and other industrial processes . AhR ligands include polycyclic aromatic hydrocarbons, including the carcinogen benzo(a)pyrene and other components of cigarette smoke. Naturally occurring AhR ligands include flavonoids, which are aromatic plant secondary compounds commonly found in vegetables and fruits. Cytoplasmic aryl hydrocarbon receptors are found in protein complexes with heat shock proteins. Upon ligand binding, AhR dissociates from heat shock proteins and translocate to the nucleus where it dimerizes with AhR nuclear translocator (ARNT, HIF-1b). The AhR/ARNT heterodimer binds to nuclear xenobiotic response elements to control the expression of genes associated with xenobiotic metabolism, including several cytochrome P450 genes. AhR is ubiquitously expressed and is thought to play a role in regulation of cell proliferation and differentiation, cytokine expression, and xenobiotic metabolism. Research studies link AhR activity with the control of regulatory T-cell and T-helper 17 cell differentiation, regulation of the inflammatory response, and the onset of lung cancer.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6q16
Cellular Component: aryl hydrocarbon receptor complex; cytoplasm; cytosol; nuclear aryl hydrocarbon receptor complex; nucleoplasm; nucleus; protein complex
Molecular Function: aryl hydrocarbon receptor activity; chaperone binding; DNA binding; DNA binding transcription factor activity; Hsp90 protein binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; protein heterodimerization activity; sequence-specific DNA binding; TATA-binding protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process: apoptosis; B cell homeostasis; blood circulation; blood vessel development; blood vessel morphogenesis; blood vessel remodeling; branching involved in blood vessel morphogenesis; camera-type eye development; cardiac left ventricle morphogenesis; cell morphogenesis; cellular response to cAMP; cellular response to glucocorticoid stimulus; circadian regulation of gene expression; circumferential growth involved in left ventricle morphogenesis; embryonic hemopoiesis; gland development; glomerulus morphogenesis; immune system process; intracellular receptor signaling pathway; liver development; lymphocyte homeostasis; negative regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of vasoconstriction; ovarian follicle development; positive regulation of cell size; positive regulation of growth rate; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of transcriptional preinitiation complex assembly; post-embryonic hemopoiesis; prostate gland development; regulation of B cell proliferation; regulation of blood vessel size; regulation of gene expression; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; reproductive structure development; response to estradiol; response to organic cyclic compound; response to toxin; response to xenobiotic stimulus; smooth muscle development; spleen development; T cell homeostasis; transcription from RNA polymerase II promoter; transcription, DNA-dependent
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Products associated with anti-AhR antibody
Pathways associated with anti-AhR antibody
Organs/Tissues associated with anti-AhR antibody
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