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anti-GOT2 antibody :: Rabbit anti-Human Aspartate aminotransferase, mitochondrial Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7006066
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aspartate aminotransferase, mitochondrial (GOT2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Aspartate aminotransferase, mitochondrial polyclonal Antibody

 Product Synonym Names    GOT2; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A
 Product Gene Name   

anti-GOT2 antibody

[Similar Products]
 Product Synonym Gene Name    GOT2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138150
 3D Structure    ModBase 3D Structure for P00505
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Aspartate aminotransferase, mitochondrial protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46707 / sc-46704
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GOT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GOT2 antibody

   Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.
 Product Categories/Family for anti-GOT2 antibody    Transport
 Applications Tested/Suitable for anti-GOT2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-GOT2 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-GOT2 antibody    Western blot
All lanes: Aspartate aminotransferase, mitochondrial antibody at 2ug/ml
lane 1:EC109 whole cell lysate
lane 2:293T whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 48,44 kDa
Observed band size: 47 kDa

anti-GOT2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GOT2 antibody    Immunohistochemistry of paraffin-embedded human liver tissue using MBS7006066 at dilution 1:100
anti-GOT2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GOT2 antibody    Immunofluorescent analysis of MCF-7 cells using MBS7006066 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-GOT2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GOT2. It may not necessarily be applicable to this product.
 NCBI GI #    555290167
 NCBI GeneID    2806
 NCBI Accession #    NP_001273149.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001286220.1 [Other Products]
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 UniProt Primary Accession #    P00505 [Other Products]
 UniProt Secondary Accession #    Q53FL3; Q9BWA3; B4DJA6; E7ERW2 [Other Products]
 UniProt Related Accession #    P00505 [Other Products]
 Molecular Weight    43,030 Da [Similar Products]
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 NCBI Official Full Name    aspartate aminotransferase, mitochondrial isoform 2
 NCBI Official Synonym Full Names    glutamic-oxaloacetic transaminase 2
 NCBI Official Symbol    GOT2 [Similar Products]
 NCBI Official Synonym Symbols   
KAT4; KATIV; mitAAT
[Similar Products]
 NCBI Protein Information    aspartate aminotransferase, mitochondrial
 UniProt Protein Name    Aspartate aminotransferase, mitochondrial
 UniProt Synonym Protein Names   
Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A
 UniProt Gene Name    GOT2 [Similar Products]
 UniProt Synonym Gene Names    mAspAT; FABP-1; FABPpm [Similar Products]
 UniProt Entry Name    AATM_HUMAN
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 NCBI Summary for GOT2    Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
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 UniProt Comments for GOT2    GOT2: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - tyrosine; EC 2.6.1.7; Mitochondrial; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 2.6.1.1; Transferase

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: cell surface; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; myelin sheath; perikaryon; plasma membrane; protein complex

Molecular Function: amino acid binding; aspartate transaminase activity; enzyme binding; identical protein binding; kynurenine-oxoglutarate transaminase activity; phospholipid binding; protein homodimerization activity; pyridoxal phosphate binding

Biological Process: 2-oxoglutarate metabolic process; 4-hydroxyproline catabolic process; amino acid biosynthetic process; aspartate biosynthetic process; aspartate catabolic process; aspartate metabolic process; carbohydrate metabolic process; fatty acid transport; gluconeogenesis; glucose metabolic process; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; glutamate metabolic process; oxaloacetate metabolic process; response to ethanol
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 Research Articles on GOT2    1. A previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GOT2 antibodyPathways associated with anti-GOT2 antibody
 Reference Product  PubMed Publications
 MDH2 antibody  >5 publications with GOT2 and MDH2
 MDH1 antibody  >3 publications with GOT2 and MDH1
 TAT antibody  >2 publications with GOT2 and TAT
 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 4-hydroxyproline Degradation Pathway antibodies  4-hydroxyproline Degradation Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram
Diseases associated with anti-GOT2 antibodyOrgans/Tissues associated with anti-GOT2 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with GOT2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >4 publications with GOT2 and Cardiovascular Diseases
 Mental Disorders Antibodies  >2 publications with GOT2 and Mental Disorders
 Liver Diseases Antibodies  >2 publications with GOT2 and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with GOT2 and Nervous System Diseases
 Fatty Liver Antibodies  >2 publications with GOT2 and Fatty Liver
 Hypertension Antibodies  >2 publications with GOT2 and Hypertension
 Cardiomyopathies Antibodies  >1 publications with GOT2 and Cardiomyopathies
 Weight Loss Antibodies  >1 publications with GOT2 and Weight Loss
 Hypertrophy Antibodies  >1 publications with GOT2 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with GOT2 and Blood
 Liver Antibodies  >6 publications with GOT2 and Liver
 Thyroid Antibodies  >3 publications with GOT2 and Thyroid
 Muscle Antibodies  >3 publications with GOT2 and Muscle
 Heart Antibodies  >3 publications with GOT2 and Heart
 Brain Antibodies  >3 publications with GOT2 and Brain
 Vascular Antibodies  >2 publications with GOT2 and Vascular
 Bladder Antibodies  >2 publications with GOT2 and Bladder
 Stomach Antibodies  >1 publications with GOT2 and Stomach
 Intestine Antibodies  >1 publications with GOT2 and Intestine
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