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anti-GOT1 antibody :: Rabbit anti-Human Aspartate aminotransferase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1488479
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aspartate aminotransferase (GOT1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Aspartate aminotransferase, cytoplasmic polyclonal Antibody

 Product Synonym Names    Glutamate oxaloacetate transaminase 1; Transaminase; GOT1
 Product Gene Name   

anti-GOT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138180
 3D Structure    ModBase 3D Structure for P17174
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Aspartate aminotransferase, cytoplasmic protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46283 / sc-46281
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GOT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GOT1 antibody

   Plays a key role in amino acid metabolism.
 Applications Tested/Suitable for anti-GOT1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-GOT1 antibody    All lanes: Aspartate aminotransferase, cytoplasmic antibody at 2ug/ml+mouse brain tissue
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 47,45 kDa
Observed band size: 46 kDa

anti-GOT1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-GOT1 antibody    Western Blot
Positive WB detected in: hepG2 cell,mouse liver,mouse skeletal muscle
All lanes: GOT1 antibody at 4.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 47,45 kDa
Observed band size: 46 kDa

anti-GOT1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GOT1 antibody    Immunohistochemistry of paraffin-embedded mouse brain using MBS1488479 at dilution of 1:50
anti-GOT1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-GOT1 antibody    Immunofluorescent analysis of HepG2 cells using MBS1488479 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-GOT1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for GOT1. It may not necessarily be applicable to this product.
 NCBI GI #    4504067
 NCBI GeneID    2805
 NCBI Accession #    NP_002070.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002079.2 [Other Products]
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 UniProt Primary Accession #    P17174 [Other Products]
 UniProt Secondary Accession #    Q5VW80; B2R6R7; B7Z7E9 [Other Products]
 UniProt Related Accession #    P17174 [Other Products]
 Molecular Weight    44,147 Da [Similar Products]
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 NCBI Official Full Name    aspartate aminotransferase, cytoplasmic
 NCBI Official Synonym Full Names    glutamic-oxaloacetic transaminase 1, soluble
 NCBI Official Symbol    GOT1 [Similar Products]
 NCBI Official Synonym Symbols   
AST1; cCAT; GIG18; cAspAT; ASTQTL1
[Similar Products]
 NCBI Protein Information    aspartate aminotransferase, cytoplasmic
 UniProt Protein Name    Aspartate aminotransferase, cytoplasmic
 UniProt Synonym Protein Names   
Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A
 Protein Family    Aspartate aminotransferase
 UniProt Gene Name    GOT1 [Similar Products]
 UniProt Synonym Gene Names    cAspAT; cCAT [Similar Products]
 UniProt Entry Name    AATC_HUMAN
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 NCBI Summary for GOT1    Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GOT1    GOT1: Plays a key role in amino acid metabolism. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Transferase; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 2.6.1.3; EC 2.6.1.1; Amino Acid Metabolism - alanine, aspartate and glutamate

Chromosomal Location of Human Ortholog: 10q24.1-q25.1

Cellular Component: cytoplasm; cytosol; lysosome; mitochondrion; nerve terminal; nucleus

Molecular Function: aspartate transaminase activity; carboxylic acid binding; cysteine transaminase activity; identical protein binding; phosphatidylserine decarboxylase activity; pyridoxal phosphate binding

Biological Process: 2-oxoglutarate metabolic process; amino acid biosynthetic process; aspartate biosynthetic process; aspartate catabolic process; aspartate metabolic process; carbohydrate metabolic process; cellular response to insulin stimulus; fatty acid homeostasis; gluconeogenesis; glucose metabolic process; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; glutamate metabolic process; glycerol biosynthetic process; methionine salvage; Notch signaling pathway; oxaloacetate metabolic process; polyamine metabolic process; response to glucocorticoid stimulus; sulfur amino acid metabolic process

Disease: Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1
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 Research Articles on GOT1    1. We propose the GOT1 expression status as a simple and reliable prognostic biomarker in pancreatic ductal adenocarcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GOT1 antibodyPathways associated with anti-GOT1 antibody
 Reference Product  PubMed Publications
 MDH1 antibody  >5 publications with GOT1 and MDH1
 IDH2 antibody  >4 publications with GOT1 and IDH2
 LDHB antibody  >3 publications with GOT1 and LDHB
 IDH1 antibody  >2 publications with GOT1 and IDH1
 MDH2 antibody  >2 publications with GOT1 and MDH2
 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram
Diseases associated with anti-GOT1 antibodyOrgans/Tissues associated with anti-GOT1 antibody
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >9 publications with GOT1 and Chromosome Aberrations
 Lung Neoplasms Antibodies  >5 publications with GOT1 and Lung Neoplasms
 Disease Models, Animal Antibodies  >5 publications with GOT1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >5 publications with GOT1 and Nervous System Diseases
 Liver Diseases Antibodies  >4 publications with GOT1 and Liver Diseases
 Fatty Liver Antibodies  >3 publications with GOT1 and Fatty Liver
 Brain Diseases Antibodies  >3 publications with GOT1 and Brain Diseases
 Cardiovascular Diseases Antibodies  >3 publications with GOT1 and Cardiovascular Diseases
 Congenital Abnormalities Antibodies  >3 publications with GOT1 and Congenital Abnormalities
 Liver Neoplasms Antibodies  >2 publications with GOT1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17 publications with GOT1 and Blood
 Liver Antibodies  >8 publications with GOT1 and Liver
 Nerve Antibodies  >7 publications with GOT1 and Nerve
 Lung Antibodies  >6 publications with GOT1 and Lung
 Brain Antibodies  >5 publications with GOT1 and Brain
 Intestine Antibodies  >4 publications with GOT1 and Intestine
 Heart Antibodies  >4 publications with GOT1 and Heart
 Muscle Antibodies  >3 publications with GOT1 and Muscle
 Vascular Antibodies  >3 publications with GOT1 and Vascular
 Thyroid Antibodies  >2 publications with GOT1 and Thyroid
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