NP_001177195.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated Molecular Weight: 68kDa Observed Molecular Weight: 70kDa
NCBI Official Full Name
autophagy-related protein 16-1 isoform 4
NCBI Official Synonym Full Names
autophagy related 16 like 1
NCBI Official Synonym Symbols
IBD10; WDR30; APG16L; ATG16A; ATG16L [Similar Products]
NCBI Protein Information
autophagy-related protein 16-1
UniProt Protein Name
Autophagy-related protein 16-1
UniProt Synonym Protein Names
APG16-like 1
UniProt Synonym Gene Names
NCBI Summary for Atg16
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
UniProt Comments for Atg16
ATG16L1: Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Autophagy; Membrane protein, peripheral
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: autophagic vacuole; axoneme; cytosol; pre-autophagosomal structure membrane
Molecular Function: GTPase binding; identical protein binding; protein binding; small conjugating protein ligase activity
Biological Process: autophagosome assembly; macroautophagy; protein homooligomerization; protein transport
Disease: Inflammatory Bowel Disease 10
Research Articles on Atg16
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Products associated with anti-Atg16 antibody
Pathways associated with anti-Atg16 antibody
Diseases associated with anti-Atg16 antibody
Organs/Tissues associated with anti-Atg16 antibody
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