NP_036636.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
sodium/potassium-transporting ATPase subunit alpha-1
NCBI Official Synonym Full Names
ATPase, Na+/K+ transporting, alpha 1 polypeptide
NCBI Official Synonym Symbols
NCBI Protein Information
sodium/potassium-transporting ATPase subunit alpha-1
UniProt Protein Name
Sodium/potassium-transporting ATPase subunit alpha-1
UniProt Synonym Protein Names
Sodium pump subunit alpha-1
UniProt Synonym Gene Names
UniProt Entry Name
AT1A1_RAT
NCBI Summary for Atp1a1
mediates Na+ and K+ transport; may play a role in regulation of blood pressure [RGD, Feb 2006]
UniProt Comments for Atp1a1
ATP1A1: the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described.
Protein type: Membrane protein, multi-pass; Transporter, ion channel; Transporter; Membrane protein, integral; EC 3.6.3.9; Hydrolase
Cellular Component: Golgi apparatus; protein complex; endoplasmic reticulum; basolateral plasma membrane; T-tubule; integral to membrane; caveola; lipid raft; membrane; apical plasma membrane; melanosome; plasma membrane; sodium:potassium-exchanging ATPase complex; myelin sheath; sarcolemma; endosome; vesicle
Molecular Function: potassium ion binding; protein domain specific binding; sodium ion binding; protein binding; chaperone binding; phosphoric monoester hydrolase activity; sodium:potassium-exchanging ATPase activity; phosphoinositide 3-kinase binding; ankyrin binding; ADP binding; protein kinase binding; ATP binding
Biological Process: response to drug; cellular sodium ion homeostasis; negative regulation of heart contraction; sodium ion transport; membrane hyperpolarization; positive regulation of striated muscle contraction; regulation of sodium ion transport; cellular potassium ion homeostasis; negative regulation of glucocorticoid biosynthetic process; dephosphorylation; energy coupled proton transport, against electrochemical gradient; potassium ion import; regulation of blood pressure; positive regulation of heart contraction; potassium ion transport; regulation of the force of heart contraction; cardiac muscle contraction
Product References and Citations for anti-Atp1a1 antibody
Shull G.E.,et al.Biochemistry 25:8125-8132(1986). Hara Y.,et al.J. Biochem. 102:43-58(1987). Herrera V.L.M.,et al.J. Cell Biol. 105:1855-1865(1987). Lubec G.,et al.Submitted (JUL-2007) to UniProtKB. Schneider J.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:6357-6361(1985).
Research Articles on Atp1a1
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Products associated with anti-Atp1a1 antibody
Pathways associated with anti-Atp1a1 antibody
Diseases associated with anti-Atp1a1 antibody
Organs/Tissues associated with anti-Atp1a1 antibody
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