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anti-BLNK antibody :: Rabbit anti-Human B Cell Linker Protein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS627881 anti-BLNK antibody
Unit / Price
0.1 mL  /  $590 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B Cell Linker Protein (BLNK), Polyclonal Antibody

 Also Known As   

B Cell Linker Protein, phosphorylated (Tyr96) (BLNK, BASH, BLNK-s, Ly57, MGC111051, SLP-65, SLP65)

 Product Synonym Names    Anti -B Cell Linker Protein, phosphorylated (Tyr96) (BLNK, BASH, BLNK-s, Ly57, MGC111051, SLP-65, SLP65)
 Product Gene Name   

anti-BLNK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (97951455..98031333, complement). Location: 10q23.2-q23.33
 3D Structure    ModBase 3D Structure for Q2MD52
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Detects endogenous levels of Tyr96 phosphorylated BLNK.
 Purity/Purification    Affinity Purified
Purified by protein A and peptide affinity chromatography.
 Form/Format    Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, BSA, 50% glycerol.
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 Immunogen    Synthetic phosphopeptide (KLH coupled) corresponding to residues around Tyr96 of human BLNK.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-BLNK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BLNK antibody

   BLNK (B cell linker protein) is an adaptor molecule that plays key roles from B cell activation through B cell antigen receptor (BCR) engagent. BLNK acts on the inferface between BCR-associated Syk and the downstream signaling cascade (1,2). BLNK has multiple SH2 binding motifs (YXXP) at its N-terminus and an SH2 domain at its C-terminus. After BCR ligation, BLNK is phosphorylated by Syk on its multiple YXXP motifs including Tyr72, Tyr84, Tyr96 and Tyr178 (1). The phosphorylation on these motifs provides docking sites for signaling molecules such as Btk, PLCgamma and Vav. They bind to BLNK through their SH2 domains and cooperatively activate downstream signaling (3,4). BLNK can also interact with phosphorylated targets such as HPK1 through its SH2 domain to activate the pathway (5).
 Product Categories/Family for anti-BLNK antibody    Antibodies; Abs to B Cells
 Applications Tested/Suitable for anti-BLNK antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-BLNK antibody    Suitable for use in Western Blotting, Immunoprecipitation.
Dilution: Western Blot: 1:1000
Immunoprecipitation: 1:100
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NCBI/Uniprot data below describe general gene information for BLNK. It may not necessarily be applicable to this product.
 NCBI GI #    166235901
 NCBI GeneID    29760
 NCBI Accession #    NP_001107566.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001114094.1 [Other Products]
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 UniProt Primary Accession #    Q2MD52 [Other Products]
 UniProt Related Accession #    Q2MD40; Q2MD42; Q2MD44; Q2MD46; Q2MD47; Q2MD48; Q2MD49; Q2MD50; Q2MD51; Q2MD52 [Other Products]
 Molecular Weight    48,201 Da [Similar Products]
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 NCBI Official Full Name    B-cell linker protein isoform 2
 NCBI Official Synonym Full Names    B-cell linker
 NCBI Official Symbol    BLNK [Similar Products]
 NCBI Official Synonym Symbols   
AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65; MGC111051
[Similar Products]
 NCBI Protein Information    B-cell linker protein; OTTHUMP00000020167; OTTHUMP00000020168; B cell linker protein; cytoplasmic adapter protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Src homology 2 domain-containing leukocyte protein of 65 kDa
 UniProt Protein Name    B-cell linker protein
 Protein Family    B-cell linker protein
 UniProt Gene Name    BASH [Similar Products]
 UniProt Synonym Gene Names    BLNK [Similar Products]
 UniProt Entry Name    Q2MD52_HUMAN
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 NCBI Summary for BLNK    This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for BLNK    BLNK iso3: an adaptor protein that bridges the B-cell receptor-associated kinases (BCR) with a multitude of signaling pathways, regulating biologic outcomes of B-cell function and development. Plays an important role in BCR-mediated PLCG1 activation and Ca(2 ) mobilization. Does not seem to be not required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Its phosphorylation is required for both Ca(2 ) and MAPK signaling pathways. Defects in BLNK are the cause of hypoglobulinemia and absent B-cells.It has tumor supressor activity that is lost in many cases of childhood pre-B acute lymphoblastic leukemia (ALL). Two alternatively spliced isoforms have been described; these are differentially involved in activation and apoptosis of B lymphocytes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10q23.2-q23.33

Cellular Component: plasma membrane; intracellular; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: positive regulation of signal transduction; B cell differentiation; inflammatory response; humoral immune response; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on BLNK    1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BLNK antibodyPathways associated with anti-BLNK antibody
 Reference Product  PubMed Publications
 SYK antibody  >61 publications with BLNK and SYK
 BTK antibody  >35 publications with BLNK and BTK
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-3, 5 And GM-CSF Signaling Pathway antibodies  Interleukin-3, 5 And GM-CSF Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
Diseases associated with anti-BLNK antibodyOrgans/Tissues associated with anti-BLNK antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >29 publications with BLNK and Neoplasms
 Vascular Diseases Antibodies  >3 publications with BLNK and Vascular Diseases
 Cardiovascular Diseases Antibodies  >3 publications with BLNK and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >2 publications with BLNK and Neoplasms, Experimental
 Bone Marrow Diseases Antibodies  >2 publications with BLNK and Bone Marrow Diseases
 Aneuploidy Antibodies  >2 publications with BLNK and Aneuploidy
 Disease Models, Animal Antibodies  >2 publications with BLNK and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with BLNK and Breast Neoplasms
 Liver Diseases Antibodies  >1 publications with BLNK and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with BLNK and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >103 publications with BLNK and Blood
 Spleen Antibodies  >15 publications with BLNK and Spleen
 Connective Tissue Antibodies  >3 publications with BLNK and Connective Tissue
 Lung Antibodies  >3 publications with BLNK and Lung
 Parathyroid Antibodies  >1 publications with BLNK and Parathyroid
 Uterus Antibodies  >1 publications with BLNK and Uterus
 Placenta Antibodies  >1 publications with BLNK and Placenta
 Lymph Node Antibodies  >1 publications with BLNK and Lymph Node
 Lymph Antibodies  >1 publications with BLNK and Lymph
 Brain Antibodies  >1 publications with BLNK and Brain
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