NP_001107566.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
B-cell linker protein isoform 2
NCBI Official Synonym Full Names
B-cell linker
NCBI Official Synonym Symbols
AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65; MGC111051 [Similar Products]
NCBI Protein Information
B-cell linker protein; OTTHUMP00000020167; OTTHUMP00000020168; B cell linker protein; cytoplasmic adapter protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Src homology 2 domain-containing leukocyte protein of 65 kDa
UniProt Protein Name
B-cell linker protein
UniProt Synonym Gene Names
UniProt Entry Name
Q2MD52_HUMAN
NCBI Summary for BLNK
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt Comments for BLNK
BLNK iso3: an adaptor protein that bridges the B-cell receptor-associated kinases (BCR) with a multitude of signaling pathways, regulating biologic outcomes of B-cell function and development. Plays an important role in BCR-mediated PLCG1 activation and Ca(2 ) mobilization. Does not seem to be not required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Its phosphorylation is required for both Ca(2 ) and MAPK signaling pathways. Defects in BLNK are the cause of hypoglobulinemia and absent B-cells.It has tumor supressor activity that is lost in many cases of childhood pre-B acute lymphoblastic leukemia (ALL). Two alternatively spliced isoforms have been described; these are differentially involved in activation and apoptosis of B lymphocytes.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10q23.2-q23.33
Cellular Component: plasma membrane; intracellular; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: positive regulation of signal transduction; B cell differentiation; inflammatory response; humoral immune response; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on BLNK
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Products associated with anti-BLNK antibody
Pathways associated with anti-BLNK antibody
Diseases associated with anti-BLNK antibody
Organs/Tissues associated with anti-BLNK antibody
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